Immune System

At the normal neuromuscular junction, a nerve cell tells a muscle cell to contract by releasing the chemical acetylcholine (ACh). ACh attaches to the ACh receptor — a pore or “channel” in the surface of the muscle cell — twisting it open and allowing an inward flux of electrical current that triggers muscle contraction.

The Activated partial thromboplastin time (aPTT) test tells you how many seconds (s) it takes your blood to form a clot after body tissue(s) or blood vessel walls were injured.

The Anti-Smith Antibody targets your body’s own proteins and is found almost exclusively in people with lupus. Though not all people with lupus have this antibody (only around 30%), those who do usually receive a diagnosis of lupus. Anti-Smith antibody is more common in blacks and Asians with SLE (around 60%) than in whites with SLE.

Antinuclear antibodies or ANAs are autoantibodies that react to substances within the nucleus of the cell. Antinuclear antibodies can react to almost anything with the nucleus including DNA, centromeres, histones, ribosomes, and other nuclear proteins.

C3 is the most abundant protein of the complement system. C3 can be cleaved in two divalent fragments, where C3b is the larger fragment. C3a is the smaller fragment that is released into the surrounding fluids. C3a can bind to receptors on basophils and mast cells triggering them to release their vasoactive amines (e.g. histamine). Because of the role of these biomarkers in anaphylaxis, C3a is called an anaphylatoxin. C3a is one of the most potent constrictors of smooth muscle cells. C3a has been shown to be a multifunctional pro-inflammatory mediator.

Anti-cyclic citrullinated peptide (anti-CCP) is an antibody present in most rheumatoid arthritis patients.

Investigation of renal/joint/connective tissue disorders and their symptoms.

Complement component 4 (C4) is a blood test that measures the activity of a certain protein. This protein is part of the complement system.

The complement C4 test is one of the most frequently used complement component tests. Your doctor may order a complement C4 test if you’re experiencing symptoms that indicate an autoimmune disease.

To help diagnose rheumatoid arthritis (RA) and differentiate it from other types of arthritis.

Evaluating patients with signs and symptoms consistent with systemic lupus erythematosus (SLE).

The erythrocyte sedimentation rate (ESR or sed rate) is a relatively simple, inexpensive, non-specific test that has been used for many years to help detect inflammation associated with conditions such as infections, cancers, and autoimmune diseases.

Histamine is a substance that is produced by the body as part of an allergic reaction.

Immature granulocytes are white blood cells that are immature. Whenever your body is fighting an infection, it will increase its white blood cell count, and more white blood cells will be immature.

Immature granulocytes are white blood cells that are immature. Whenever your body is fighting an infection, it will increase its white blood cell count, and more white blood cells will be immature.

Immunoglobulin E (IgE) are antibodies produced by the immune system. 

Immunoglobulin G (IgG), the most abundant type of antibody, is found in all body fluids and protects against bacterial and viral infections.

Interleukin-6 is involved in inflammation and infection responses and also in the regulation of metabolic, regenerative, and neural processes.

This test measures the amount of antibodies to anti-Jo-1 in blood. It is used to help diagnose and manage muscle diseases that affects the immune system such as polymyositis (a type of chronic inflammation of the muscles) associated with autoimmune disease.

These antibodies target a human body’s produced enzyme called cytochrome P450 2D6, a protein found primarily in liver cells which catalyze many reactions involved in drug metabolism. The development of the LKM antibodies is strongly associated with type 2 autoimmune hepatitis.

Lupus anticoagulants are antibodies against substances in the lining of cells. These substances prevent blood clotting in a test tube.

Prothrombin time (PT) is a blood test that measures the time it takes for the liquid portion (plasma) of your blood to clot.

Prothrombin time (PT) is a blood test that measures the time it takes for the liquid portion (plasma) of your blood to clot. 

The rheumatoid arthritis (RA) latex turbid test is a laboratory test that’s used to help your doctor diagnose rheumatoid arthritis and other autoimmune diseases.

A rheumatoid factor test measures the amount of rheumatoid factor in your blood. Rheumatoid factors are proteins produced by your immune system that can attack healthy tissue in your body.

Transforming Growth Factor (TGF) plays a crucial role in tissue regeneration, cell differentiation, embryonic development, and regulation of the immune system.

Thrombin is an enzyme in the blood that acts on the clotting factor fibrinogen to form fibrin, helping blood to clot. The thrombin time assesses the activity of fibrinogen.

Transforming growth factor (TGF-beta) is a multifunctional peptide growth factor that has an important role in the regulation of cell growth, differentiation, and repair in a variety of tissues.

Tryptase is an enzyme that is released, along with histamine and other chemicals, from mast cells when they are activated as part of a normal immune response as well as in allergic (hypersensitivity) responses.

VEGF stands for Vascular Endothelial Growth Factor. VEGF is a growth factor that promotes the growth of new blood vessels.