The Anti-C1Q Ab, IgG (RDL) test measures the levels of IgG antibodies against C1q in a patient's blood.
What is C1q?
C1q is a protein that plays a crucial role in the complement system, which is a part of the immune system responsible for recognizing and clearing pathogens and damaged cells from the body.
Patients with suspected autoimmune conditions, particularly lupus nephritis, may undergo this test as part of their diagnostic workup.
Systemic lupus erythematosus (SLE) is an autoimmune disease with multiorgan involvement. Approximately 37-45% of patients with SLE will develop lupus nephritis, which negatively impacts patient survival. Testing for C1q antibodies assists in evaluating the risk of lupus nephritis development.
- Not all patients with lupus nephritis will be positive for C1q antibodies
- The presence of C1q antibodies is not specific for SLE
Elevated levels of Anti-C1Q antibodies, specifically IgG, can be associated with various autoimmune diseases, particularly lupus nephritis, a kidney disorder linked to systemic lupus erythematosus (SLE). This test is valuable in diagnosing and monitoring autoimmune diseases, especially those affecting the kidneys.
A positive result for Anti-C1Q Ab, IgG may suggest an increased risk of renal flares in individuals with lupus nephritis. Serial testing can show changes in antibody levels, providing insights into the progression or management of the disease.
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