C3a desArg Fragment

Immune System

A healthy result should fall into the range 55 - 486 ng/mL.

C3 is the most abundant protein of the complement system. C3 can be cleaved in two divalent fragments, where C3b is the larger fragment. C3a is the smaller fragment that is released into the surrounding fluids. C3a can bind to receptors on basophils and mast cells triggering them to release their vasoactive amines (e.g. histamine). Because of the role of these biomarkers in anaphylaxis, C3a is called an anaphylatoxin. C3a is one of the most potent constrictors of smooth muscle cells. C3a has been shown to be a multifunctional pro-inflammatory mediator.

  • C3a may be an indicator of a Lyme-related issue if the Lyme is in an acute stage.
  • Although C3a was shown to be elevated in a cohort of early, acute Lyme disease patients, it appears to be normal in chronic Lyme patients. 
  • In mold, C3a is normal and C4a is high.

References:

  • https://www.ncbi.nlm.nih.gov/pubmed/18270493
  • https://www.ncbi.nlm.nih.gov/pubmed/19140878
  • https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780290905
  • https://www.ncbi.nlm.nih.gov/pubmed/3263085
  • https://www.karger.com/Article/FullText/328238
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1959484/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753731/
  • https://www.ncbi.nlm.nih.gov/pubmed/16586433
  • https://www.ncbi.nlm.nih.gov/pubmed/20012107
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532535/
  • https://www.ncbi.nlm.nih.gov/pubmed/25520093
  • https://www.ncbi.nlm.nih.gov/pubmed/19601884
  • https://www.ncbi.nlm.nih.gov/pubmed/21615487
  • https://jacewellness.com/articles/Lab%20Testing%20for%20water%20damaged%20building%20illness.pdf 
  • https://www.survivingmold.com/docs/Resources/Shoemaker%20Papers/Lyme_acute_C4a_1_08_glovsky.pdf

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