desArg = without arginine
C3a desArg is a cleavage product of C3 complement component activation. Elevated levels of C3a have been reported in patients with acute lyme disease, acute pancreatitis, systemic lupus erythematosus, and adult respiratory distress syndrome.
C3 is the most abundant protein of the complement system. C3 can be cleaved in two divalent fragments, where C3b is the larger fragment. C3a is the smaller fragment that is released into the surrounding fluids. C3a can bind to receptors on basophils and mast cells triggering them to release their vasoactive amines (e.g. histamine). Because of the role of these biomarkers in anaphylaxis, C3a is called an anaphylatoxin. C3a is one of the most potent constrictors of smooth muscle cells. C3a has been shown to be a multifunctional pro-inflammatory mediator.
- C3a may be an indicator of a Lyme-related issue if the Lyme is in an acute stage.
- Although C3a was shown to be elevated in a cohort of early, acute Lyme disease patients, it appears to be normal in chronic Lyme patients.
- In mold, C3a is normal and C4a is high.
References:
https://www.ncbi.nlm.nih.gov/pubmed/18270493
https://www.ncbi.nlm.nih.gov/pubmed/19140878
https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780290905
https://www.ncbi.nlm.nih.gov/pubmed/3263085
https://www.karger.com/Article/FullText/328238
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1959484/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753731/
https://www.ncbi.nlm.nih.gov/pubmed/16586433
https://www.ncbi.nlm.nih.gov/pubmed/20012107
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532535/
https://www.ncbi.nlm.nih.gov/pubmed/25520093
https://www.ncbi.nlm.nih.gov/pubmed/19601884
https://www.ncbi.nlm.nih.gov/pubmed/21615487
https://jacewellness.com/articles/Lab%20Testing%20for%20water%20damaged%20building%20illness.pdf
https://www.survivingmold.com/docs/Resources/Shoemaker%20Papers/Lyme_acute_C4a_1_08_glovsky.pdf
Low C3a levels may increase the risk of infections and inflammation.
- An inherited deficiency of C3 predisposes patients to frequent bouts of bacterial infections.
- Gestational Diabetes - this occurs when healthy women develop high blood sugar levels during pregnancy.
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C3a desArg is a cleavage product of C3 complement component activation. Elevated levels of C3a have been reported in patients with acute lyme disease, acute pancreatitis, systemic lupus erythematosus, and adult respiratory distress syndrome.
Complement C3a was found to be elevated in patients with:
- Inflammation (such as asthma)
- Autoimmune diseases [C3a levels were increased in patients with severe and moderately active lupus (SLE).]
- Chronic hepatitis C, and HCV-related hepatitis cell carcinoma.
- In a recent study, all acute Lyme disease patients had elevated levels of C3a, hence C3a (and C4a) can be regarded as an early marker of acute lyme disease in patients seen shortly after tick bite.
- Smoking
- Stroke
- Chronic hepatitis/liver cancer
- Colon cancer
- Pancreas inflammation
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14.3.3 ETA PROTEIN, Acetylcholine Receptor (AChR) Antibody, Activated partial thromboplastin time (APTT), Alpha 2-Macroglobulins, Qn, ANA SCREEN A, ANA SCREEN B, ANA SCREEN, IFA, ANA titer, Anti-C1Q Ab, IgG (RDL), Anti-DBL-Strand DNA Ab, Anti-dsDNA (Double-stranded) Ab by Farr method (RDL), Anti-Smith Antibody, Anticardiolipin Ab, IgM, Anticardiolipin Ab,IgA,Qn, Anticardiolipin Ab,IgG,Qn, Antinuclear Antibodies (ANA) Screen, Reflex ANA IFA dsDNA Antibodies, Antinuclear Antibodies Direct (ANA Direct), Antiphosphatidylserine IgA, Antiphosphatidylserine IgG, Antiphosphatidylserine IgM, Baski sleepy, C1 Esterase Inhibitor, Func, C1 Esterase Inhibitor, Serum, C3A Desarg Fragment, CARDIOLIPIN AB (IGA), CARDIOLIPIN AB (IGG), CARDIOLIPIN AB (IGM), Carnitine, Free, Carnitine, Total, CCP Antibodies IgG/IgA, Centromere, Chromatin, Coccidioides Ab by CF, Coccidioides Ab, IgG, EIA, Coccidioides Ab, IgM, EIA, Complement C3, Complement C3a, Complement C4, Serum, Complement C4a, Complement, Total (CH50), Complement, Total (CH50) / Quest, Cyclic Citrullinated Peptide Antibody, Dilute Russell's viper venom time (dRVVT), Diphtheria Antitoxoid Antibody, DNA AB Double Stranded Titer, DNA Double-Stranded Ab, IgG, DRVVT SCREEN, ds-DNA Antibody, IgG, dsDNA, Erythrocyte Sedimentation Rate (ESR), F004-IgE Wheat, Free Kappa Lt Chains, Serum, Free Lambda Lt Chains, Serum, Gastrin, Histamine, Plasma, Histone, HLA-B27 (Human Leukocyte Antigen B27), Immature Grans (Abs), Immature Granulocytes (%), Immunofixation Result, Serum, Immunoglobulin A, Qn, Serum, Immunoglobulin D, Quant, Serum, Immunoglobulin E, Total, Immunoglobulin G, Qn, Serum, Immunoglobulin M, Qn, Serum, Interleukin-2, Serum, Interleukin-6, Jo 1 Antibodies, IgG, Serum, JO-1, Kappa/Lambda Ratio, Serum, Liver-Kidney Microsomal Antibodies, Lupus Anticoagulant, Measles Antibodies, IgG, Mumps Abs, IgG, PHOSPHATIDYLETHANOLAMINE AB (IGA), PHOSPHATIDYLETHANOLAMINE AB (IGG), PHOSPHATIDYLETHANOLAMINE AB (IGM), PHOSPHATIDYLSERINE AB (IGA), PHOSPHATIDYLSERINE AB (IGG), PHOSPHATIDYLSERINE AB (IGM), Plasminogen Activator Inhibitor (PAI-1) AG, Prothrombin Fragment 1.2, Prothrombin Time (PT), Prothrombin Time (PT) INR, RA Latex Turbid, Reptilase Clotting Time, RF, IgA by EIA (RDL), RF, IgG by EIA (RDL), RF, IgM by EIA (RDL), Rheumatoid factor (RF), RNP/Sm, Scl-70, Sm, SM/RNP Antibody, SSA, SSB, ssDNA, Tetanus Antitoxoid IgG Ab, TGF-b1, Thrombin time, Thrombin-Antithrombin TAT, Transforming Growth Factor beta, Plasma, Tryptase, Varicella-Zoster Virus (VZV) DNA, Qualitative, Real-Time PCR, VEGF, Plasma, Von Willebrand Factor Antigen (vWF), vWF Activity
