1018 Celiac Profile - Serum
Serum
Performed by: Genova Diagnostics
Celiac Profile - Serum (Genova Diagnostics): Understanding Your Results
The "1018 Celiac Profile - Serum" by Genova Diagnostics is a comprehensive blood test designed to identify celiac disease and gluten sensitivity. This panel measures critical biomarkers that indicate immune reactions to gluten, helping pinpoint potential celiac disease, gluten intolerance, or related autoimmune issues.
What Is Celiac Disease?
Celiac disease is an autoimmune disorder where the ingestion of gluten—found in wheat, barley, and rye—triggers an immune response that damages the small intestine lining. Untreated, it can lead to malabsorption, nutrient deficiencies, and other health complications.
What Does the Celiac Profile Measure?
The Genova Celiac Profile - Serum assesses:
- Anti-Tissue Transglutaminase (tTG) IgA & IgG: Key antibodies produced when gluten triggers an immune response. Elevated levels may suggest celiac disease.
- Deamidated Gliadin Peptide (DGP) IgA & IgG: Detects sensitivity to gluten peptides, offering additional accuracy in diagnosis.
- Total Immunoglobulin A (IgA): Measures overall IgA levels to rule out IgA deficiency, which can affect test accuracy.
Who Should Consider the Celiac Profile?
You may benefit from this test if you experience:
- Chronic digestive issues (bloating, diarrhea, or constipation)
- Unexplained fatigue or nutrient deficiencies (e.g., iron, B12)
- Skin rashes (e.g., dermatitis herpetiformis)
- Autoimmune conditions, such as thyroid disorders or type 1 diabetes
Benefits of the 1018 Celiac Profile
- Comprehensive Panel: Evaluates multiple immune markers for a more accurate diagnosis.
- Non-Invasive: A simple blood draw provides valuable insights.
- Early Detection: Helps identify celiac disease or gluten sensitivity early, enabling dietary changes to prevent long-term complications.
Why Choose Genova Diagnostics?
Genova Diagnostics is a trusted name in functional testing, delivering accurate, clinically actionable results to help individuals take control of their health.
Next Steps After Testing
If your results suggest celiac disease or gluten sensitivity, working with a healthcare provider to adopt a gluten-free diet can alleviate symptoms and improve your quality of life. Further testing, such as intestinal biopsies or genetic testing, may be recommended for confirmation.
How to interpret this:
Step 1: Total IgA Measurement
- Sufficient IgA: If Total IgA levels are normal, tests using tTG IgA (anti-tissue transglutaminase IgA) can be trusted.
- Insufficient IgA: If Total IgA levels are low, the body may not produce enough IgA antibodies. In this case, testing switches to tTG IgG and DGP IgG (IgG-based markers).
Step 2: If Total IgA Is Sufficient
- tTG IgA Test:
- Positive: If tTG IgA is positive, celiac disease is likely.
- Next Step: Consider a biopsy of the small intestine to confirm diagnosis.
- Negative or Equivocal: If tTG IgA is negative or unclear:
- Perform DGP IgA and/or EMA IgA (Endomysial antibodies).
- Positive: Suggests celiac disease is likely → proceed to biopsy.
- Negative: Celiac disease is unlikely.
- Positive: If tTG IgA is positive, celiac disease is likely.
Step 3: If Total IgA Is Insufficient
If IgA is low, rely on IgG-based tests:
- Test for tTG IgG and DGP IgG:
- Positive or Equivocal:
- Perform HLA Testing (to check genetic predisposition to celiac disease).
- Positive HLA: Consider a biopsy to confirm diagnosis.
- Negative HLA: Celiac disease is unlikely.
- Perform HLA Testing (to check genetic predisposition to celiac disease).
- Negative: Celiac disease is unlikely.
- Positive or Equivocal:
Key Summary
- Start with Total IgA to check immune function.
- If IgA is normal, rely on tTG IgA for initial testing.
- If IgA is low, use tTG IgG and DGP IgG instead.
- Positive or unclear results may require HLA testing and, ultimately, a biopsy to confirm celiac disease.
- Negative results throughout the process make celiac disease unlikely.
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Biomarkers included in this panel:
Anti-Deamidated Gliadin IgA (DGP IgA) is a key marker for detecting celiac disease by measuring IgA antibodies against gluten fragments (deamidated gliadin peptides). It’s especially useful for identifying early-stage disease or confirming uncl
Learn moreAnti-Deamidated Gliadin IgG (DGP IgG) is a key marker for detecting celiac disease and gluten sensitivity, especially in individuals with IgA deficiency or unclear test results. Elevated DGP IgG levels suggest an immune reaction to gluten, indicating
Learn moreAnti-Tissue Transglutaminase IgA (tTG IgA) is the primary and most reliable test for detecting celiac disease, measuring IgA antibodies produced in response to gluten. Elevated levels strongly suggest celiac disease, as they indicate immune-driven da
Learn moreAnti-Tissue Transglutaminase IgG (tTG IgG) is a key marker used in celiac disease testing, particularly for individuals with IgA deficiency, where standard tTG IgA results may be unreliable. Elevated tTG IgG levels suggest the immune system is reacti
Learn moreTotal IgA
The Total IgA biomarker on the 1018 Celiac Profile - Serum by Genova Diagnostics measures the overall levels of Immunoglobulin A (IgA), an essential antibody that plays a crucial role in the immune system, particularly at mucosal surfaces like the ga
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