Toxic Non-Metal Chemical Profile
Every day, we are exposed to hundreds of toxic chemicals through products like pharmaceuticals, pesticides, packaged foods, household products, and environmental pollution. As we have become more exposed to chemical-laden products and to toxic chemicals in food, air, and water, we have been confronted with an accelerating rate of chronic illnesses like cancer, heart disease, chronic fatigue syndrome, chemical sensitivity, autism spectrum disorders, ADD/AD(H)D, autoimmune disorders, Parkinson’s disease, and Alzheimer’s disease.
Because exposure to environmental pollutants has been linked to many chronic diseases, The Great Plains Laboratory has created GPL-TOX, a toxic non-metal chemical profile that screens for the presence of 172 different toxic chemicals including organophosphate pesticides, phthalates, benzene, xylene, vinyl chloride, pyrethroid insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene oxide, acrylonitrile, and more. This profile also includes Tiglylglycine (TG), a marker for mitochondrial disorders resulting from mutations of mitochondrial DNA. These mutations can be caused by exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.
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Biomarkers included in this panel:
2,4-Dichlorophenoxyacetic Acid (2,4-D) is a very common herbicide that was a part of Agent Orange, which was used by the U.S. in the Vietnam War. It is most commonly used in agriculture on genetically modified foods, and as a weed killer for lawns. E
Learn more2-Methylhippuric Acid (2MHA), 3-Methylhippuric Acid (3MHA), 4-Methylhippuric Acid (4MHA) These are metabolites of xylenes, solvents found in paints, lacquers, cleaning agents, pesticides, and gasoline. Exposure to xylenes generates methylhippur
Learn moreHEMA is a metabolite of ethylene oxide, which is used in the production of agrochemicals, detergents, pharmaceuticals, and personal care products. Chronic exposure to ethylene oxide has been determined to be mutagenic to humans.
Learn more2-Hydroxyisobutyric acid is formed endogenously as a product of branched-chain amino acid degradation and ketogenesis. This compound is also the major metabolite of gasoline octane enhancers such as MTBE and ETBE.
Learn more3-HPMA is the main urinary metabolite of acrolein. Acrolein is an environmental pollutant, commonly used as an herbicide and in many different chemical industries. Acrolein is also present in the burning of cigarettes, gasoline, and oil. Certain bact
Learn morePyrethrins are widely used as insecticides. Exposure during pregnancy doubles the likelihood of autism. Pyrethrins may affect neurological development, disrupt hormones, induce cancer, and suppress the immune system.
Learn moreOrganophosphates are one of the most toxic groups of substances in the world, primarily found in pesticide formulations. They are inhibitors of cholinesterase enzymes, leading to overstimulation of nerve cells, causing sweating, salivation, diarrhea,
Learn moreOrganophosphates are one of the most toxic groups of substances in the world, primarily found in pesticide formulations. They are inhibitors of cholinesterase enzymes, leading to overstimulation of nerve cells, causing sweating, salivation, diarrhea,
Learn moreThis is a metabolite of the organophosphate flame retardant triphenyl phosphate (TPHP), which is used in plastics, electronic equipment, nail polish, and resins. TPHP can cause endocrine disruption. Studies have also linked TPHP to reproductive and d
Learn moreGlyphosate is the world's most widely produced herbicide. It is a broad-spectrum herbicide that is used in more than 700 different products for agriculture and forestry to home use. Possible treatment options if in higher ranges: Treatment
Learn moreMonoethyl Phthalate (or Monoethylphthalate) (MEP) from diethyl phthalate is the most abundant phthalate metabolite found in urine. Diethyl phthalate is used in plastic products. Elevated values indicate exposure from various possible source
Learn moreN-acetyl phenyl cysteine (NAP) is a metabolite of benzene. Benzene is an organic solvent that is widespread in the environment. Benzene is a by-product of all types of industrial processes and combustion, including motor vehicle exhaust and
Learn moreNACE is a metabolite of acrylonitrile, which is used in the production of acrylic fibers, resins, and rubber. Acrylonitrile is metabolized by the cytochrome P450s and then conjugated to glutathione. Supplementation with glutathione should assist i
Learn moreN-acetyl(2-hydroxypropyl)cysteine (NAHP) is used in the production of plastics and is used as a fumigant (=gaseous pesticides). This chemical is a metabolite of propylene oxide. Propylene oxide is used to make polyester resins for t
Learn moreNADB is a metabolite of 1,3 butadiene, which is evident of exposure to synthetic rubber such as tires. 1,3 butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease. Individuals that come into contact with rubber
Learn moreNAPR is a metabolite of 1-bromopropane. Chronic exposure can lead to decreased cognitive function and impairment of the central nervous system. Acute exposure can lead to headaches. 1-bromopropane is an organic solvent used for metal cleanin
Learn moreN-acetyl-S-(2-carbamoylethyl)cysteine (NAE) is a metabolite of acrylamide, which is detoxified through a two-step process. First acrylamide is metabolized by the cytochrome P450s. Second it is conjugated to glutathione in order to make i
Learn moreThe chemical Perchlorate (PERC) is used in the production of rocket fuel, missiles, fireworks, flares, explosives, fertilizers, and bleach. Studies show that perchlorate is often found in water supplies. Many food sources are also contamina
Learn moreStyrene is used in the manufacturing of plastics, in building materials, and is found in car exhaust fumes. Polystyrene and its copolymers are widely used as food-packaging materials. The ability of styrene monomer to leach from polystyrene packaging
Learn moreTiglylglycine is a marker for mitochondrial dysfunction. Mutations of mitochondria DNA may result from exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.
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