Advanced Intestinal Barrier Assessment (Plasma)
Plasma
Performed by: Precision Point Diagnostics
Precision Point Diagnostics: Advanced IBA Profile for Intestinal Barrier Assessment
The Advanced Intestinal Barrier Assessment (IBA) profile from Precision Point Diagnostics offers an in-depth evaluation of intestinal barrier function. By utilizing a collection of innovative biomarkers, this test helps clinicians determine if their patients are experiencing intestinal permeability, commonly known as "leaky gut." Intestinal permeability is often linked to autoimmune diseases, systemic inflammation, and food sensitivities. Addressing gut barrier health is critical for resolving chronic diseases—without proper gut healing, other treatments may have limited effectiveness.
Key Biomarkers in the Advanced IBA Profile
The Advanced IBA profile features unique and clinically relevant markers that provide a comprehensive view of gut barrier health:
- Histamine & Diamine Oxidase (DAO): These markers offer insights into histamine regulation and the health of the gut mucosa.
- Plasma Zonulin: A reliable indicator of intestinal tight junction integrity, Plasma Zonulin is the preferred marker for assessing gut barrier function.
- Lipopolysaccharides (LPS) & LPS Antibodies: LPS, produced by gram-negative bacteria, are endotoxins that can contribute to inflammation. LPS antibodies provide valuable information about intestinal permeability and associated inflammatory responses.
This test is beneficial for patients suffering from allergies, food sensitivities, digestive issues, headaches, cognitive decline, depression, and other related conditions (refer to the Table of Associated Symptoms and Conditions for more details).
Personalized Treatment Plans Based on IBA Results
The Advanced IBA profile enables clinicians to develop tailored treatment plans based on each patient's specific test results, ensuring more effective and targeted interventions. Since no two patients are the same, protocols to improve intestinal permeability must be individualized. The Advanced IBA profile helps identify the root cause of barrier dysfunction, making treatment more efficient, cost-effective, and successful.
Some patients may need to focus on balancing DAO and histamine levels, while others may need to address the underlying causes of Zonulin elevation or high LPS antibodies. With this precise approach, clinicians can effectively address the root causes of intestinal permeability and guide their patients back to health.
By using the Advanced IBA profile, practitioners can pinpoint and treat intestinal permeability issues, ultimately helping their patients achieve long-term wellness.
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Biomarkers included in this panel:
DAO: Histamine Ratio
The DAO:Histamine ratio helps identify subtle imbalances between histamine levels and DAO enzyme activity. Even if DAO levels are within the normal range, symptoms may still occur if histamine levels are elevated. A low ratio indicates that the amoun
Learn moreDiamine Oxidase (DAO)
Diamine Oxidase (DAO) and Histamine Regulation Diamine Oxidase (DAO) is a crucial enzyme responsible for regulating histamine levels by breaking down extracellular histamine, primarily in the microvilli of the small intestine. When DAO levels are
Learn moreHistamine
Maintaining a proper balance of histamine is crucial for individuals with allergic and gastrointestinal symptoms. Both excessively high and low levels of histamine can lead to health issues. Histamine was initially identified for its role in anaphyla
Learn moreLPS IgA
LPS IgG
LPS IgM
Zonulin
Zonulin, a protein that regulates the permeability of the intestinal lining, plays a key role in maintaining the gut barrier. It breaks down tight junctions between the cells in the gastrointestinal (GI) tract, which are essential for protecting the
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