EARLY SJOGRENS SYNDROME PROFILE

Sjögren syndrome is an autoimmune disease characterized by lymphocyte infiltration of exocrine glands, which manifests as dry eyes and mouth. The syndrome is estimated to be between 9 and 20 times more common in women than in men and typically presents in the 4th or 5th decade of life. The disease can present by itself (primary) or in association with another underlying autoimmune condition (secondary), commonly rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). Sjögren syndrome may occur as part of a triad that includes primary biliary cirrhosis (PBC) and autoimmune thyroid disease. Patients with Sjögren's syndrome also have an overall increased risk for malignancies, specifically non-Hodgkin lymphoma and thyroid cancer.