ANA Comprehensive Panel

This test helps to detect and helps diagnose certain autoimmune disorders, such as lupus and Sjögren syndrome, among other types.

Antinuclear antibodies (ANA) are a group of autoantibodies produced by a person's immune system when it fails to adequately distinguish between "self" and "nonself." The ANA test detects these autoantibodies in the blood.

ANA react with components of the body's own healthy cells and cause signs and symptoms such as tissue and organ inflammation, joint and muscle pain, and fatigue. ANA specifically target substances found in the nucleus of a cell, hence the name "antinuclear." They probably do not damage living cells because they cannot access their nuclei. However, ANA can cause damage to tissue by reacting with nuclear substances when they are released from injured or dying cells.

The ANA test is one of the primary tests for helping to diagnose a suspected autoimmune disorder or rule out other conditions with similar signs and symptoms. The ANA test may be positive with several autoimmune disorders. Patients with the autoimmune disorder systemic lupus erythematosus (SLE) are almost always positive for ANA, but the percentage of patients with other autoimmune disorders who have positive ANA results varies. Also, a significant number of patients with a variety of other types of disorders (and even some heathy people) may be positive for ANA, especially at low levels.

Anti-DNA (DS) Ab Qn

Optimal range: 0 - 9 IU/ml

The anti-dsDNA test identifies the presence of these autoantibodies in the blood.

The test for anti-dsDNA, along with other autoantibody tests, may be used to help establish a diagnosis of lupus and distinguish it from other autoimmune disorders.

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Anti-Jo-1

Optimal range: 0 - 0.9 AI

Antichromatin Antibodies

Optimal range: 0 - 0.9 AI

RNP Antibodies, IgG, Serum

Optimal range: 0 - 0.99 Units

A positive result for RNP antibodies is consistent with a connective tissue disease. Although strongly associated with connective tissue diseases, RNP antibodies are not considered a "marker" for any particular disease except in the following situation: when found in isolation (ie, dsDNA antibodies and Sm antibodies are not detectable), a positive result for RNP antibodies is consistent with the diagnosis of mixed connective tissue disease. 

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Smith Antibodies

Optimal range: 0 - 0.9 AI

Smith antigens, along with RNP antigens, are part of small nuclear RNAs. Levels of antibodies to these two antigens are often elevated in SLE. The Smith antigen is composed of the B1, D, and E proteins.

Anti-Smith antibody has low sensitivity but high specificity for systemic lupus erythematosus (SLE). It is occasional present in mixed connective-tissue disease (MCTD).

Anti-Smith antibody levels are elevated in up to 30% of SLE cases and 8% of MCTD cases.

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