Tryptase

Optimal Result: 2.2 - 13.2 ug/L.

This test measures the amount of tryptase in the blood.

Other names: 

- Mast Cell Tryptase 

- Alpha Tryptase 

- Beta Tryptase 

- Mature Tryptase

Tryptase is an enzyme that is released, along with histamine and other chemicals from mast cells when they are activated as part of a normal immune response as well as in allergic responses. 

What are mast cells?

Mast cells, which are granulocytes found in peripheral tissue, play a central role in inflammatory and immediate allergic reactions. 

They are present in the highest amounts in:

- the skin 

- the lining of the intestine

- air passages, 

- and the bone marrow

They contain granules (=particles) that store a number of chemicals, including tryptase and histamine. When mast cells are activated, they release their contents. If a person has too many mast cells (=mastocytosis) and/or the cells are activated inappropriately, the chemicals that are released (especially histamine) may cause symptoms that range from moderate to life-threatening.

Normal conditions:

Normally, the level of tryptase in the blood is very low.

References:

  • Mast cell tryptase: a review of its physiology and clinical significance. [L]
  • Clinical significance of serum tryptase, Nam, Young-Hee et al., Journal of Allergy and Clinical Immunology, Volume 141, Issue 2, AB162 [L]
  • Patient Reported Symptoms and Tryptase Levels in WHO-Defined Systemic Mastocytosis (SM) Versus Mast Cell Activation Syndrome (MCAS) Versus Neither, Darci Zblewski, Ramy A. Abdelrahman, Dong Chen, Joseph H. Butterfield, Ayalew Tefferi, Animesh Pardanani, Blood Dec 2014, 124 (21) 3204 [L]
  • https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/81608
  • https://labtestsonline.org/tests/tryptase

What does it mean if your Tryptase result is too high?

- When mast cells are activated, the level increases rapidly, rising within 15 to 30 minutes, peaking at 1 to 2 hours, and returning to normal after several hours to a couple of days. In people with severe allergies, activation of many mast cells can cause an extreme form of allergic reaction (=anaphylaxis), which can cause low blood pressure, hives (blisters on the skin), severe narrowing of the air passages, and even death. Tryptase levels will be very high in people with anaphylaxis.

- In some cases, tryptase levels will be high in persons with mast cell activation disorders, in which mast cells become activated without apparent allergies or other reasons.

- Tryptase levels can also be significantly and persistently increased with mastocytosis, a rare group of disorders associated with an abnormal increase in the number of mast cells. These cells may accumulate in the skin (=cutaneous mastocytosis) or in organs throughout the body (=systemic mastocytosis).

Symptoms:

While cutaneous mastocytosis typically only causes skin problems (particularly hives), people with systemic mastocytosis or a mast cell activation disorder may experience anaphylaxis and its associated symptoms. These symptoms may be persistent and are related to the organs affected by mast cell accumulation. Systemic mastocytosis may progress slowly or may be aggressive, causing organ dysfunction and, in rare cases, causing a form of leukemia.

10 000+ happy customers
100% satisfaction
★ ★ ★ ★ ★ customer support

Understand blood, stool, and urine medical results from all your laboratories.

Upload Your Personal Results

Upload Personal Results

For professional account plans go here

for professional account plans go here

Monthly plan

Annual plan

Own it for life

  • Subscription
  • Data entry service included

    Data entry service

    Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.

  • Instant interpretation
  • Use free data entry form

    Free data entry form

    We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.

  • 4000+ biomarkers explained
  • Nutrition recommendations
  • Cancel anytime

Complete

$15 /month

billed every month

  • monthly
  • $15 per report
  • ✓ Instant interpretations
  • ✓ 4000+ biomarkers explained
  • ✓ Nutrition recommendations
  • ✓ Free data entry form
  • ✓ Unlimited data
  • ✓ $15 data entry service
  • ✓ Cancel anytime

Most popular

Data entry included

Advanced

$79 /year

$6.60/month billed annually

  • yearly
  • 5 reports free
  • ✓ Instant interpretations
  • ✓ 4000+ biomarkers explained
  • ✓ Nutrition recommendations
  • ✓ We enter 5 reports for you
  • ✓ Yearly subscription
  • ✓ Cancel anytime

Data entry included

Unlimited

$250 /once

own it for life

  • pay once
  • 10 reports free
  • ✓ Instant interpretations
  • ✓ 4000+ biomarkers explained
  • ✓ Nutrition recommendations
  • ✓ We enter 10 reports for you
  • ✓ No subscription
  • ✓ Dedicated support
  • ✓ Unlimited access

Are You a Health Professional?

Get started with our professional plan

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more

Pro Monthly Plus

for health professionals

  • ✓ Track multiple clients results
  • ✓ No setup fees
  • ✓ No hidden costs
  • ✓ Instant interpretations
  • ✓ 4000+ biomarkers explained
  • ✓ Includes data entry service
  • ✓ Personal training and support
  • ✓ Cancel anytime

$75 per month

Use promo code to save 10% off any plan.


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.