A healthy result should fall into the range 2.2 - 13.2 ug/L.
This test measures the amount of tryptase in the blood.
- Mast Cell Tryptase
- Alpha Tryptase
- Beta Tryptase
- Mature Tryptase
Tryptase is an enzyme that is released, along with histamine and other chemicals from mast cells when they are activated as part of a normal immune response as well as in allergic responses.
What are mast cells?
Mast cells, which are granulocytes found in peripheral tissue, play a central role in inflammatory and immediate allergic reactions.
They are present in the highest amounts in:
- the skin
- the lining of the intestine
- air passages,
- and the bone marrow
They contain granules (=particles) that store a number of chemicals, including tryptase and histamine. When mast cells are activated, they release their contents. If a person has too many mast cells (=mastocytosis) and/or the cells are activated inappropriately, the chemicals that are released (especially histamine) may cause symptoms that range from moderate to life-threatening.
Normally, the level of tryptase in the blood is very low.
- When mast cells are activated, the level increases rapidly, rising within 15 to 30 minutes, peaking at 1 to 2 hours, and returning to normal after several hours to a couple of days. In people with severe allergies, activation of many mast cells can cause an extreme form of allergic reaction (=anaphylaxis), which can cause low blood pressure, hives (blisters on the skin), severe narrowing of the air passages, and even death. Tryptase levels will be very high in people with anaphylaxis.
- In some cases, tryptase levels will be high in persons with mast cell activation disorders, in which mast cells become activated without apparent allergies or other reasons.
- Tryptase levels can also be significantly and persistently increased with mastocytosis, a rare group of disorders associated with an abnormal increase in the number of mast cells. These cells may accumulate in the skin (=cutaneous mastocytosis) or in organs throughout the body (=systemic mastocytosis).
While cutaneous mastocytosis typically only causes skin problems (particularly hives), people with systemic mastocytosis or a mast cell activation disorder may experience anaphylaxis and its associated symptoms. These symptoms may be persistent and are related to the organs affected by mast cell accumulation. Systemic mastocytosis may progress slowly or may be aggressive, causing organ dysfunction and, in rare cases, causing a form of leukemia.
$15 per monthSelect this plan
$59 per yearSelect this plan
$250 single paymentSelect this plan
Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.Get Started
"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly."
"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily."
"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."