The 14-3-3eta protein is a marker of synovial inflammation that is released into synovial fluid and peripheral blood in rheumatoid arthritis (RA) and erosive psoriatic arthritis.
- One in five RF and CCP seronegative early stage RA patients is found to be positive for 14-3-3eta protein.
- Patients with active joint RA disease have higher values of 14-3-3eta protein than those with inactive RA or psoriasis without arthritis.
- 14-3-3eta protein has a 93% specificity in patients with RA.
Unlike RF and CCP, 14-3-3eta protein is a therapeutically modifiable marker to monitor response to therapy. A decrease in 14-3-3eta protein in response to DMARDs (disease-modifying antirheumatic drugs) and anti-TNF (tumor necrosis factor) drugs indicates better clinical outcomes; an increase is associated with worse outcomes despite apparent clinical remission.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
- Values > or=0.2 ng/mL are elevated and indicative of RA disease or erosive psoriatic arthritis.
- Values >0.50 ng/mL are associated with more aggressive RA disease and poorer outcomes.
Interpret Your Lab Results
Upload your lab report and we’ll interpret and provide you with recomendations today.
Get StartedGet Started With Our Personal Plan
Advanced Plan
Unlimited Plan
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Plan
for health professionals
$45 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
14.3.3 ETA PROTEIN, Acetylcholine Receptor (AChR) Antibody, Activated partial thromboplastin time (APTT), ANA SCREEN, IFA, ANA titer, Anti-DBL-Strand DNA Ab, Anti-Smith Antibody, Anticardiolipin Ab,IgG,Qn, Antinuclear Antibodies Direct (ANA Direct), C1 Esterase Inhibitor, Func, CARDIOLIPIN AB (IGA), CARDIOLIPIN AB (IGG), CARDIOLIPIN AB (IGM), CCP Antibodies IgG/IgA, Complement C3, Complement C3a, Complement C4, Serum, Complement C4a, Complement, Total (CH50), Complement, Total (CH50) / Quest, Cyclic Citrullinated Peptide Antibody, Dilute Russell's viper venom time (dRVVT), DRVVT SCREEN, ds-DNA Antibody, IgG, Erythrocyte Sedimentation Rate (ESR), Histamine, Plasma, HLA-B27 (Human Leukocyte Antigen B27), Immature Grans (Abs), Immature Granulocytes (%), Immunofixation Result, Serum, Immunoglobulin A, Qn, Serum, Immunoglobulin D, Quant, Serum, Immunoglobulin E, Total, Immunoglobulin G, Qn, Serum, Immunoglobulin M, Qn, Serum, Interleukin-2, Serum, Interleukin-6, Jo 1 Antibodies, IgG, Serum, Liver-Kidney Microsomal Antibodies, Lupus Anticoagulant, PHOSPHATIDYLETHANOLAMINE AB (IGA), PHOSPHATIDYLETHANOLAMINE AB (IGG), PHOSPHATIDYLETHANOLAMINE AB (IGM), PHOSPHATIDYLSERINE AB (IGA), PHOSPHATIDYLSERINE AB (IGG), PHOSPHATIDYLSERINE AB (IGM), Prothrombin Time (PT), Prothrombin Time (PT) INR, RA Latex Turbid, Reptilase Clotting Time, Rheumatoid factor, TGF-b1, Thrombin time, Transforming Growth Factor beta, Plasma, Tryptase, VEGF, Plasma