The 14-3-3eta protein is a marker of synovial inflammation that is released into synovial fluid and peripheral blood in rheumatoid arthritis (RA) and erosive psoriatic arthritis.
- One in five RF and CCP seronegative early stage RA patients is found to be positive for 14-3-3eta protein.
- Patients with active joint RA disease have higher values of 14-3-3eta protein than those with inactive RA or psoriasis without arthritis.
- 14-3-3eta protein has a 93% specificity in patients with RA.
Unlike RF and CCP, 14-3-3eta protein is a therapeutically modifiable marker to monitor response to therapy. A decrease in 14-3-3eta protein in response to DMARDs (disease-modifying antirheumatic drugs) and anti-TNF (tumor necrosis factor) drugs indicates better clinical outcomes; an increase is associated with worse outcomes despite apparent clinical remission.
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- Values > or=0.2 ng/mL are elevated and indicative of RA disease or erosive psoriatic arthritis.
- Values >0.50 ng/mL are associated with more aggressive RA disease and poorer outcomes.
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14.3.3 ETA PROTEIN, Acetylcholine Receptor (AChR) Antibody, Activated partial thromboplastin time (APTT), ANA SCREEN, IFA, ANA titer, Anti-DBL-Strand DNA Ab, Anti-Smith Antibody, Anticardiolipin Ab,IgG,Qn, Antinuclear Antibodies Direct (ANA Direct), C1 Esterase Inhibitor, Func, CARDIOLIPIN AB (IGA), CARDIOLIPIN AB (IGG), CARDIOLIPIN AB (IGM), CCP Antibodies IgG/IgA, Complement C3, Complement C3a, Complement C4, Serum, Complement C4a, Complement, Total (CH50), Complement, Total (CH50) / Quest, Cyclic Citrullinated Peptide Antibody, Dilute Russell's viper venom time (dRVVT), DRVVT SCREEN, ds-DNA Antibody, IgG, Erythrocyte Sedimentation Rate (ESR), Histamine, Plasma, HLA-B27 (Human Leukocyte Antigen B27), Immature Grans (Abs), Immature Granulocytes (%), Immunofixation Result, Serum, Immunoglobulin A, Qn, Serum, Immunoglobulin D, Quant, Serum, Immunoglobulin E, Total, Immunoglobulin G, Qn, Serum, Immunoglobulin M, Qn, Serum, Interleukin-2, Serum, Interleukin-6, Jo 1 Antibodies, IgG, Serum, Liver-Kidney Microsomal Antibodies, Lupus Anticoagulant, PHOSPHATIDYLETHANOLAMINE AB (IGA), PHOSPHATIDYLETHANOLAMINE AB (IGG), PHOSPHATIDYLETHANOLAMINE AB (IGM), PHOSPHATIDYLSERINE AB (IGA), PHOSPHATIDYLSERINE AB (IGG), PHOSPHATIDYLSERINE AB (IGM), Prothrombin Time (PT), Prothrombin Time (PT) INR, RA Latex Turbid, Reptilase Clotting Time, Rheumatoid factor, TGF-b1, Thrombin time, Transforming Growth Factor beta, Plasma, Tryptase, VEGF, Plasma
