Immune System

Complement C3

Optimal Result: 90 - 180 mg/dL.

Measurements of serum complement components C3 is useful in the diagnosis and monitoring of immune complex disease e.g. SLE (Systemic lupus erythematosus) and some blood associated infectious diseases. Complement concentrations are acute phase proteins and may be normal, despite complement consumption, in some inflammatory and infective disorders. C3 alone is often decreased in infectious disease (septicaemia, endocarditis).

Measurement of serum complement is useful in the monitoring of specific immune complex diseases e.g SLE and infectious diseases post streptococcal disease, subacute bacterial endocarditis.

Though genetic deficiencies of C3 are exceedingly rare, deficiencies in other components which are more common (though still very rare) can result in low C3.

The normal adult range for C3 is 90-180mg/dl.


What does it mean if your Complement C3 result is too low?

Values <1mg/dl can be found in active immune complex disease, septicaemia, bacteraemia, post streptococcal glomerulonephritis or diseases associated with nephritic factor. Low levels of C3 associated with low levels of C4 demonstrate classical pathway activation and strongly suggest immune complex disease. They are found most commonly in cases of active SLE (Systemic lupus erythematosus). Low levels of C3 associated with normal levels of C4 demonstrate alternative pathway activation suggestive of infectious disease or nephritic factor activity.

Although in some long standing SLE patients C3 levels remain low, which does not necessarily denote active disease, a sudden fall in levels does usually indicate exacerbation of disease activity and a risk of renal damage.

What does it mean if your Complement C3 result is too high?

Values up to twice this upper limit are found in acute phase.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Understand blood, stool, and urine medical results from your labs.

Get 10% off your plan.

Use promocode

Advanced Plan personal plan

  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium personal plan

  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Pro Plan for health professionals

  • Track multiple clients results
  • No setup fees
  • No hidden costs
  • Cancel anytime
  • Instant interpretations
  • Use the free template forms
  • 2500+ biomarkers explained
  • Additional team member $25
  • Personal training and support software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals

Understand Your Lab Result Now

  • Instant interpretation
  • 2500+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode: