Complement C3

Immune System

A healthy result should fall into the range 90 - 180 mg/dL.

Measurements of serum complement components C3 is useful in the diagnosis and monitoring of immune complex disease e.g. SLE (Systemic lupus erythematosus) and some blood associated infectious diseases. Complement concentrations are acute phase proteins and may be normal, despite complement consumption, in some inflammatory and infective disorders. C3 alone is often decreased in infectious disease (septicaemia, endocarditis).

Measurement of serum complement is useful in the monitoring of specific immune complex diseases e.g SLE and infectious diseases post streptococcal disease, subacute bacterial endocarditis.

Though genetic deficiencies of C3 are exceedingly rare, deficiencies in other components which are more common (though still very rare) can result in low C3.

The normal adult range for C3 is 90-180mg/dl.


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