PEP A2Glob, also known as Pepsinogen A2 Globulin, is a specific biomarker of considerable interest in the field of gastroenterology and digestive health. Pepsinogen, an inactive precursor of the enzyme pepsin, plays a critical role in protein digestion within the stomach. It is secreted by the gastric chief cells and is converted to active pepsin in the acidic environment of the stomach. The A2 globulin variant of pepsinogen, or PEP A2Glob, is one of the multiple isoforms of pepsinogen. Elevated levels of PEP A2Glob can be indicative of certain gastric conditions. For instance, increased levels are often observed in patients with peptic ulcer disease, as the body may produce more pepsinogen in response to the ulceration. Conversely, significantly low levels of PEP A2Glob can be a marker for atrophic gastritis, a condition characterized by the gradual loss of gastric glandular cells, leading to reduced acid and pepsinogen production. The measurement of PEP A2Glob levels, therefore, assists in the diagnosis and monitoring of these gastric conditions. Additionally, alterations in PEP A2Glob levels have been studied in relation to gastric cancer and H. pylori infection, providing valuable insights into the pathophysiology of these conditions. The assessment of PEP A2Glob, alongside other diagnostic parameters, is essential for a comprehensive understanding of various gastrointestinal disorders and for tailoring appropriate treatment strategies.
What does it mean if your PEP A2Glob result is too high?
Elevated levels of Pepsinogen A2 Globulin (PEP A2Glob) typically indicate an increase in the stomach's production of pepsinogen, which is a precursor to the enzyme pepsin responsible for protein digestion. High levels of PEP A2Glob can be suggestive of peptic ulcer disease, where the body may produce more pepsinogen in response to ulceration in the stomach or duodenum. This increase is part of the body's attempt to aid in digestion and repair, although it can exacerbate the ulcerative condition. Elevated PEP A2Glob might also be observed in conditions such as gastritis, where there is inflammation of the stomach lining.
In terms of treatment, the approach largely depends on the underlying cause of the elevated levels. For peptic ulcers, treatment usually involves medications to reduce stomach acid, such as proton pump inhibitors (PPIs) or H2 blockers, alongside antibiotics if Helicobacter pylori (H. pylori) bacteria are present. Dietary modifications, such as avoiding spicy foods, alcohol, and NSAIDs (nonsteroidal anti-inflammatory drugs), can also help manage symptoms and promote healing. In the case of gastritis, treatment may include similar acid-reducing medications and dietary changes, along with addressing any specific causes (like infection or autoimmune reactions). It's important for individuals with elevated PEP A2Glob levels to work closely with their healthcare provider to determine the exact cause of the imbalance and receive tailored treatment. Regular monitoring and follow-up are also crucial to assess the effectiveness of the treatment and make adjustments as needed.
All Your Lab Results.
One Simple Dashboard.
Import, Track, and Share Your Lab Results Easily
Import, Track, and Share Your Lab Results
Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.
Cancel or upgrade anytime
Laboratories
Bring All Your Lab Results Together — In One Place
We accept reports from any lab, so you can easily collect and organize all your health information in one secure spot.
Pricing Table
Gather Your Lab History — and Finally Make Sense of It
Finally, Your Lab Results Organized and Clear
Personal plans
$79/ year
Advanced Plan
Access your lab reports, explanations, and tracking tools.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 5 reports entered for you
- Cancel or upgrade anytime
$250/ once
Unlimited Account
Pay once, access everything—no monthly fees, no limits.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 10 reports entered for you
- No subscriptions. No extra fees.
$45/ month
Pro Monthly
Designed for professionals managing their clients' lab reports
- Import lab results from any provider
- Track lab results for multiple clients
- Customize reference ranges per client
- Export lab histories and reports
- Begin with first report entered by us
- Cancel or upgrade anytime
About membership
What's included in a Healthmatters membership
Import Lab Results from Any Source
See Your Health Timeline
Understand What Your Results Mean
Visualize Your Results
Data Entry Service for Your Reports
Securely Share With Anyone You Trust
Let Your Lab Results Tell the Full Story
Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.
Bring all your results together to compare, track progress, export your history, and share securely.
What Healthmatters Members Are Saying
Frequently asked questions
Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
- Individuals who want to track and understand their health over time.
- Health professionals, such as doctors, nutritionists, and wellness coaches, need to manage and interpret lab data for their clients.
With a Healthmatters account, you can:
- Upload lab reports from any lab
- View your data in interactive graphs, tables, and timelines
- Track trends and monitor changes over time
- Customize your reference ranges
- Export and share your full lab history
- Access your results anytime, from any device
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 10000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
- The GI Effects® Comprehensive Stool Profile,
- GI-MAP,
- The NutrEval FMV®,
- The ION Profile,
- Amino Acids Profile,
- Dried Urine Test for Comprehensive Hormones (DUTCH),
- Organic Acids Test,
- Organix Comprehensive Profile,
- Toxic Metals,
- Complete Blood Count (CBC),
- Metabolic panel,
- Thyroid panel,
- Lipid Panel,
- Urinalysis,
- And many, many more.
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
We implement proven measures to keep your data safe.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.