Organix Comprehensive Profile - Urine

The Organix Comprehensive Profile is a nutritional test providing insights into organic acids and a view into the body's cellular metabolic processes. 

Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the biomarkers are markers of intestinal bacterial or yeast overgrowth.

The Organix Comprehensive nutritional test profile provides vital patient information from a single urine specimen. This organic acids nutritional test is valuable for determining:

  • Functional vitamin and mineral status
  • Amino acid insufficiencies like carnitine and NAC
  • Oxidative damage and antioxidant need
  • Phase I & Phase II detoxification capacity
  • Functional B-complex vitamin need
  • Neurotransmitter metabolites
  • Mitochondrial energy production
  • Methylation sufficiency
  • Lipoic acid and CoQ10 status
  • Markers for bacterial and yeast overgrowth

2-Methylhippurate

Optimal range: 0 - 0.192 mcg/mg creatinine

2-Methylhippurate is a byproduct of detoxification of the common solvent xylene. Urinary excretion of 2-methylhippurate is a sensitive and specific marker for xylene exposure which increases oxidative stress.

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3,4 Dihydroxyphenylpropionate

Optimal range: 0 - 0.05 mcg/mg creatinine

3,4-Dihydroxyphenylpropionate seems to be strongly associated with a troublesome type of bacteria called Clostridia.

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5-hydroxyindoleacetate (Genova)

Optimal range: 1.6 - 9.8 mcg/mg creatinine

5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors.

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8-Hydroxy-2'-deoxyguanosine

Optimal range: 0 - 7.6 ng/mg creatinine

8-hydroxy-2’-deoxyguanosine measures the oxidative impact to DNA. 8-hydroxy-2’-deoxyguanosine levels will be high if your total antioxidant protection is inadequate.

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Adipate

Optimal range: 0 - 11.1 mcg/mg creatinine

Adipate, together with Suberate and Ethylmalonate are all functional markers for deficiency of carnitine.

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Alpha-Hydroxybutyrate

Optimal range: 0 - 0.9 mcg/mg creatinine

Alpha-Hydroxybutyrate is a by-product of glutathione production. Levels of alpha-hydroxybutyrate in the urine may reflect levels of glutathione production.

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Alpha-Keto-Beta-Methylvalerate

Optimal range: 0 - 1.1 mcg/mg creatinine

Alpha-Keto-Beta-Methylvalerate is a B-Complex Vitamin Marker. Vitamins are compounds that your body needs to be healthy. Vitamins are “essential” for proper function, which means that they are not made inside your body and must be consumed in the diet.

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Alpha-Ketoglutarate

Optimal range: 0 - 35 mcg/mg creatinine

Alpha-Ketoglutarate is an organic acid that is important for the proper metabolism of all essential amino acids. It is formed in the Krebs cycle, the energy-producing process that occurs in most body cells.

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Alpha-Ketoisocaproate

Optimal range: 0 - 0.52 mcg/mg creatinine

Alpha-Ketoisocaproate is a B-Complex Vitamin Marker (Leucine catabolism).

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Alpha-Ketoisovalerate

Optimal range: 0 - 0.49 mcg/mg creatinine

Benzoate

Optimal range: 0 - 9.3 mcg/mg creatinine

Benzoate, was one of the compounds first found to be elevated in urine from patients with intestinal bacterial overgrowth of various origins.

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Beta-Hydroxybutyrate

Optimal range: 0 - 9.9 mcg/mg creatinine

Beta-Hydroxyisovalerate

Optimal range: 0 - 11.5 mcg/mg creatinine

cis-Aconitate

Optimal range: 18 - 78 mcg/mg creatinine

cis-Aconitate is involved in both energy production and removal of toxic ammonia.

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Citrate

Optimal range: 56 - 987 mcg/mg creatinine

D-Arabinitol

Optimal range: 0 - 73 mcg/mg creatinine

D-Arabinitol is a marker for intestinal yeast overgrowth.

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D-Lactate

Optimal range: 0 - 4.1 mcg/mg creatinine

D-Lactate is produced by bacteria residing in the colon when carbohydrates are not completely absorbed in the small intestine. This by-product is excreted in the urine.

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Ethylmalonate

Optimal range: 0 - 6.3 mcg/mg creatinine

Ethylmalonate, together with Adipate and Suberate, gives information about your ability to process fatty acids.

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Formiminoglutamate

Optimal range: 0 - 2.2 mcg/mg creatinine

Fumarate

Optimal range: 0 - 1.35 mcg/mg creatinine

Glucarate

Optimal range: 0 - 10.7 mcg/mg creatinine

Hippurate

Optimal range: 0 - 1070 mcg/mg creatinine

Microbes resident in the large intestine of the human body help to break down complex aromatic compounds in dietary plant matter (polyphenols), freeing up benzoic acid, which enters the bloodstream. The liver can add the amino acid glycine to benzoic acid to form hippuric acid, which re-enters the blood and is absorbed by the kidneys. As a result, the kidneys excrete hundreds of milligrams of hippuric acid into the urine every day.

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Histamine

Optimal range: 4 - 71 ug/g creat

Homovanillate (Genova)

Optimal range: 1.4 - 7.6 mcg/mg creatinine

Hydroxymethylglutarate

Optimal range: 0 - 5.1 mcg/mg creatinine

Indican

Optimal range: 0 - 90 mcg/mg creatinine

Indican is an indole produced when bacteria in the intestine act on the amino acid, tryptophan. Most indoles are excreted in the feces. The remainder is absorbed, metabolized by the liver, and excreted as indicanin the urine.

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Isocitrate

Optimal range: 39 - 143 mcg/mg creatinine

Ketoisovalerate

Optimal range: 0 - 0 mcg/mg creatinine

Kynurenate

Optimal range: 0 - 1.5 mcg/mg creatinine

Kynurenate is product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Your body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein.

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L-Lactate

Optimal range: 0.6 - 16.4 mcg/mg creatinine

Malate

Optimal range: 0 - 3.1 mcg/mg creatinine

Malate is involved in the citric acid cycle (aka. Krebs cycle). The citric acid cycle is a series of reactions that occur in the mitochondrion to generate chemical energy that fuels the metabolism.

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Methylmalonate (Genova)

Optimal range: 0 - 2.3 mcg/mg creatinine

Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production.

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Orotate

Optimal range: 0 - 1.01 mcg/mg creatinine

p-Hydroxybenzoate

Optimal range: 0 - 1.8 mcg/mg creatinine

The presence of organic compounds such as p-Hydroxybenzoate in the urine may point towards significant dysbiosis (=impaired microbiota).

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p-Hydroxyphenylacetate

Optimal range: 0 - 34 mcg/mg creatinine

p-Hydroxyphenyllactate

Optimal range: 0 - 0.66 mcg/mg creatinine

p-hydroxyphenyllactate is a marker of cell turnover. It is also a metabolite in tyrosine degradation and may be useful for studying disorders of tyrosine metabolism.

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Phenylacetate

Optimal range: 0 - 0.18 mcg/mg creatinine

Produced from bacterial degradation of unabsorbed phenylalanine.

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Phenylpropionate

Optimal range: 0 - 0.06 mcg/mg creatinine

Picolinate

Optimal range: 2.8 - 13.5 mcg/mg creatinine

Picolinate is a neurotransmitter metabolism marker and is produced under inflammatory conditions.

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Pyroglutamate (Genova)

Optimal range: 28 - 88 mcg/mg creatinine

Pyruvate (Genova)

Optimal range: 0 - 6.4 mcg/mg creatinine

Quinolinic acid (Quinolinate) (Genova)

Optimal range: 0 - 5.8 mcg/mg creatinine

Quinolinic acid is a neurotoxic substance produced by our own bodies and a metabolite of tryptophan.

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Suberate

Optimal range: 0 - 4.6 mcg/mg creatinine

Succinate

Optimal range: 0 - 20.9 mcg/mg creatinine

Sulfate

Optimal range: 690 - 2988 mcg/mg creatinine

Sulfate is associated with your body’s use of glutathione, an amino acid critical for removing toxins that is also a powerful antioxidant.

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Tricarballylate

Optimal range: 0 - 1.41 mcg/mg creatinine

Tricarballylate is produced by a strain of aerobic bacteria. It binds to magnesium which results in magnesium deficiency.

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Vanilmandelate (Genova)

Optimal range: 1.2 - 5.3 mcg/mg creatinine

Xanthurenate (Genova)

Optimal range: 0 - 0.46 mcg/mg creatinine

Your body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein. Inadequate vitamin B6 is one factor that leads to increased concentrations of kynurenate and xanthurenate in urine.

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