Organix Comprehensive Profile - Urine

The Organix Comprehensive Profile is a nutritional test providing insights into organic acids and a view into the body's cellular metabolic processes. 

Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the biomarkers are markers of intestinal bacterial or yeast overgrowth.

The Organix Comprehensive nutritional test profile provides vital patient information from a single urine specimen. This organic acids nutritional test is valuable for determining:

  • Functional vitamin and mineral status
  • Amino acid insufficiencies like carnitine and NAC
  • Oxidative damage and antioxidant need
  • Phase I & Phase II detoxification capacity
  • Functional B-complex vitamin need
  • Neurotransmitter metabolites
  • Mitochondrial energy production
  • Methylation sufficiency
  • Lipoic acid and CoQ10 status
  • Markers for bacterial and yeast overgrowth

2-Methylhippurate

Optimal range: 0 - 0.192 mcg/mg creatinine

2-Methylhippurate is a byproduct of detoxification of the common solvent xylene. Urinary excretion of 2-methylhippurate is a sensitive and specific marker for xylene exposure which increases oxidative stress.

LEARN MORE

3,4 Dihydroxyphenylpropionate

Optimal range: 0 - 0.05 mcg/mg creatinine

3,4-Dihydroxyphenylpropionate seems to be strongly associated with a troublesome type of bacteria called Clostridia.

LEARN MORE

5-hydroxyindoleacetate (Genova)

Optimal range: 1.6 - 9.8 mcg/mg creatinine

5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors.

LEARN MORE

8-Hydroxy-2'-deoxyguanosine

Optimal range: 0 - 7.6 ng/mg creatinine

8-hydroxy-2’-deoxyguanosine measures the oxidative impact to DNA. 8-hydroxy-2’-deoxyguanosine levels will be high if your total antioxidant protection is inadequate.

LEARN MORE

Adipate

Optimal range: 0 - 11.1 mcg/mg creatinine

Adipate, together with Suberate and Ethylmalonate are all functional markers for deficiency of carnitine.

LEARN MORE

Alpha-Hydroxybutyrate

Optimal range: 0 - 0.9 mcg/mg creatinine

Alpha-Hydroxybutyrate is a by-product of glutathione production. Levels of alpha-hydroxybutyrate in the urine may reflect levels of glutathione production.

LEARN MORE

Alpha-Keto-Beta-Methylvalerate

Optimal range: 0 - 1.1 mcg/mg creatinine

Alpha-Ketoglutarate

Optimal range: 0 - 35 mcg/mg creatinine

Alpha-Ketoglutarate is an organic acid that is important for the proper metabolism of all essential amino acids. It is formed in the Krebs cycle, the energy-producing process that occurs in most body cells.

LEARN MORE

Alpha-Ketoisocaproate

Optimal range: 0 - 0.52 mcg/mg creatinine

Alpha-Ketoisocaproate is a B-Complex Vitamin Marker (Leucine catabolism).

LEARN MORE

Alpha-Ketoisovalerate

Optimal range: 0 - 0.49 mcg/mg creatinine

Benzoate

Optimal range: 0 - 9.3 mcg/mg creatinine

Benzoate, was one of the compounds first found to be elevated in urine from patients with intestinal bacterial overgrowth of various origins.

LEARN MORE

Beta-Hydroxybutyrate

Optimal range: 0 - 9.9 mcg/mg creatinine

Beta-Hydroxyisovalerate

Optimal range: 0 - 11.5 mcg/mg creatinine

cis-Aconitate

Optimal range: 18 - 78 mcg/mg creatinine

Citrate

Optimal range: 56 - 987 mcg/mg creatinine

D-Arabinitol

Optimal range: 0 - 73 mcg/mg creatinine

D-Lactate

Optimal range: 0 - 4.1 mcg/mg creatinine

Ethylmalonate

Optimal range: 0 - 6.3 mcg/mg creatinine

Formiminoglutamate

Optimal range: 0 - 2.2 mcg/mg creatinine

Fumarate

Optimal range: 0 - 1.35 mcg/mg creatinine

Glucarate

Optimal range: 0 - 10.7 mcg/mg creatinine

Hippurate

Optimal range: 0 - 1070 mcg/mg creatinine

Histamine

Optimal range: 4 - 71 ug/g creat

Homovanillate (Genova)

Optimal range: 1.4 - 5.3 mcg/mg creatinine

Hydroxymethylglutarate

Optimal range: 0 - 5.1 mcg/mg creatinine

Indican

Optimal range: 0 - 90 mcg/mg creatinine

Isocitrate

Optimal range: 39 - 143 mcg/mg creatinine

Ketoisovalerate

Optimal range: 0 - 0 mcg/mg creatinine

Kynurenate

Optimal range: 0 - 1.5 mcg/mg creatinine

Kynurenate is product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Your body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein.

LEARN MORE

L-Lactate

Optimal range: 0.6 - 16.4 mcg/mg creatinine

Malate

Optimal range: 0 - 3.1 mcg/mg creatinine

Methylmalonate (Genova)

Optimal range: 0 - 2.3 mcg/mg creatinine

Orotate

Optimal range: 0 - 1.01 mcg/mg creatinine

p-Hydroxybenzoate

Optimal range: 0 - 1.8 mcg/mg creatinine

The presence of organic compounds such as p-Hydroxybenzoate in the urine may point towards significant dysbiosis (=impaired microbiota).

LEARN MORE

p-Hydroxyphenylacetate

Optimal range: 0 - 34 mcg/mg creatinine

p-Hydroxyphenyllactate

Optimal range: 0 - 0.66 mcg/mg creatinine

Phenylacetate

Optimal range: 0 - 0.18 mcg/mg creatinine

Phenylpropionate

Optimal range: 0 - 0.06 mcg/mg creatinine

Picolinate

Optimal range: 2.8 - 13.5 mcg/mg creatinine

Pyroglutamate (Genova)

Optimal range: 28 - 88 mcg/mg creatinine

Pyruvate (Genova)

Optimal range: 0 - 6.4 mcg/mg creatinine

Quinolinic acid

Optimal range: 0 - 5.8 mcg/mg creatinine

Quinolinic acid is a neurotoxic substance produced by our own bodies and a metabolite of tryptophan.

LEARN MORE

Suberate

Optimal range: 0 - 4.6 mcg/mg creatinine

Succinate

Optimal range: 0 - 20.9 mcg/mg creatinine

Sulfate

Optimal range: 690 - 2988 mcg/mg creatinine

Tricarballylate

Optimal range: 0 - 1.41 mcg/mg creatinine

Tricarballylate is produced by a strain of aerobic bacteria. It binds to magnesium which results in magnesium deficiency.

LEARN MORE

Vanilmandelate (Genova)

Optimal range: 1.2 - 5.3 mcg/mg creatinine

Xanthurenate (Genova)

Optimal range: 0 - 0.46 mcg/mg creatinine