Organix Comprehensive Profile - Urine

The Organix Comprehensive Profile is a nutritional test providing insights into organic acids and a view into the body's cellular metabolic processes.
Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the biomarkers are markers of intestinal bacterial or yeast overgrowth.
The Organix Comprehensive nutritional test profile provides vital patient information from a single urine specimen. This organic acids nutritional test is valuable for determining:
- Functional vitamin and mineral status
- Amino acid insufficiencies like carnitine and NAC
- Oxidative damage and antioxidant need
- Phase I & Phase II detoxification capacity
- Functional B-complex vitamin need
- Neurotransmitter metabolites
- Mitochondrial energy production
- Methylation sufficiency
- Lipoic acid and CoQ10 status
- Markers for bacterial and yeast overgrowth
2-Methylhippurate
Optimal range: 0 - 0.192 mcg/mg creatinine
2-Methylhippurate is a byproduct of detoxification of the common solvent xylene. Urinary excretion of 2-methylhippurate is a sensitive and specific marker for xylene exposure which increases oxidative stress.
LEARN MORE3,4-Dihydroxyphenylpropionate
Optimal range: 0 - 0.05 mcg/mg creatinine
3,4-Dihydroxyphenylpropionate seems to be strongly associated with a troublesome type of bacteria called Clostridia.
LEARN MORE5-Hydroxyindoleacetate
Optimal range: 1.6 - 9.8 mcg/mg creatinine
5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors.
LEARN MORE8-Hydroxy-2-deoxyguanosine
Optimal range: 0 - 7.6 ng/mg creatinine
8-hydroxy-2-deoxyguanosine measures the oxidative impact to DNA. 8-hydroxy-2-deoxyguanosine levels will be high if your total antioxidant protection is inadequate.
LEARN MOREAdipate
Optimal range: 0 - 11.1 mcg/mg creatinine
Adipate, together with Suberate and Ethylmalonate are all functional markers for deficiency of carnitine.
LEARN MOREAlpha-Hydroxybutyrate
Optimal range: 0 - 0.9 mcg/mg creatinine
Alpha-Hydroxybutyrate is a by-product of glutathione production. Levels of alpha-hydroxybutyrate in the urine may reflect levels of glutathione production.
LEARN MOREAlpha-Keto-Beta-Methylvalerate
Optimal range: 0 - 1.1 mcg/mg creatinine
Alpha-Keto-Beta-Methylvalerate is a B-Complex Vitamin Marker. Vitamins are compounds that your body needs to be healthy. Vitamins are “essential” for proper function, which means that they are not made inside your body and must be consumed in the diet.
Alpha-Ketoglutarate
Optimal range: 0 - 35 mcg/mg creatinine
Alpha-Ketoglutarate is an organic acid that is important for the proper metabolism of all essential amino acids. It is formed in the Krebs cycle, the energy-producing process that occurs in most body cells.
LEARN MOREAlpha-Ketoisocaproate
Optimal range: 0 - 0.52 mcg/mg creatinineAlpha-Ketoisovalerate
Optimal range: 0 - 0.49 mcg/mg creatinine
Alpha-Ketoisovalerate (together with Alpha-Ketoisocaproate and Alpha-Keto-Beta-methylvalerate) requires Vitamins B1, B2, B3, B5 and lipoic acid to be metabolized.
LEARN MOREBenzoate
Optimal range: 0 - 9.3 mcg/mg creatinine
Benzoate, was one of the compounds first found to be elevated in urine from patients with intestinal bacterial overgrowth of various origins.
LEARN MOREBeta-Hydroxybutyrate
Optimal range: 0 - 9.9 mcg/mg creatinineBeta-Hydroxyisovalerate
Optimal range: 0 - 11.5 mcg/mg creatinine
Beta-Hydroxyisovalerate is a sensitive indicator of biotin deficiency and is a metabolite of the amino acid isoleucine.
LEARN MOREcis-Aconitate
Optimal range: 18 - 78 mcg/mg creatinineCitrate
Optimal range: 56 - 987 mcg/mg creatinine
Citric acid, cis-aconitic acid, and isocitric acid are the first three metabolites in the Krebs Citric Acid energy production cycle, which operates in the mitochondria of your cells.
LEARN MORED-Arabinitol
Optimal range: 0 - 73 mcg/mg creatinine
D-Arabinitol is a marker for intestinal yeast overgrowth.
Yeast is another class of microbes that can chronically grow in the intestinal tract and cause adverse health effects through the release of toxic metabolites. D-Arabinitol is uniquely produced by intestinal yeast, and the degree of elevation is a useful marker of their growth.
D-arabinitol is produced from dietary carbohydrates when yeasts are rapidly growing in the low oxygen environment of the small intestine.
LEARN MORED-Lactate
Optimal range: 0 - 4.1 mcg/mg creatinine
D-Lactate is produced by bacteria residing in the colon when carbohydrates are not completely absorbed in the small intestine. This by-product is excreted in the urine.
LEARN MOREEthylmalonate
Optimal range: 0 - 6.3 mcg/mg creatinine
Ethylmalonate, together with Adipate and Suberate, gives information about your ability to process fatty acids.
LEARN MOREFormiminoglutamate
Optimal range: 0 - 2.2 mcg/mg creatinine
Formiminoglutamate (FIGLU) is a functional marker of insufficiency of folic acid, another B-vitamin, and is a compound made from the amino acid histidine.
LEARN MOREFumarate
Optimal range: 0 - 1.35 mcg/mg creatinine
Fumarate (together with Succinate and Malate) is used in the body’s metabolic pathway that generates cellular energy – the Citric Acid Cycle.
LEARN MOREGlucarate
Optimal range: 0 - 10.7 mcg/mg creatinine
Glucarate helps your liver perform its important role in removing from your body many types of toxins such as pesticides, prescription drugs, food components, and intestinal bacteria.
LEARN MOREHippurate
Optimal range: 0 - 1070 mcg/mg creatinine
Microbes resident in the large intestine of the human body help to break down complex aromatic compounds in dietary plant matter (polyphenols), freeing up benzoic acid, which enters the bloodstream. The liver can add the amino acid glycine to benzoic acid to form hippuric acid, which re-enters the blood and is absorbed by the kidneys. As a result, the kidneys excrete hundreds of milligrams of hippuric acid into the urine every day.
LEARN MOREHistamine
Optimal range: 4 - 71 ug/g creat
Histamine is a compound that affects immune response and physiological function of the digestive tract, and also acts as a neurotransmitter.
Histamine helps control the sleep-wake cycle as well as energy and motivation.
LEARN MOREHomovanillate (Genova)
Optimal range: 1.4 - 7.6 mcg/mg creatinine
Homovanillate (aka Homovanillic Acid) is a dopamine metabolite.
Homovanillate and Vanilmandelate are breakdown products from neurotransmitters involved in hormone and nerve impulse transmission, called catecholamines.
LEARN MOREHydroxymethylglutarate
Optimal range: 0 - 5.1 mcg/mg creatinine
Hydroxymethylglutarate (HMG) is the precursor to Coenzyme Q10 (CoQ10) production, and when it is elevated it may indicate that the body is trying to increase its production of CoQ10.
LEARN MOREIndican
Optimal range: 0 - 90 mcg/mg creatinine
Indican is an indole produced when bacteria in the intestine act on the amino acid, tryptophan. Most indoles are excreted in the feces. The remainder is absorbed, metabolized by the liver, and excreted as indicanin the urine.
LEARN MOREIsocitrate
Optimal range: 39 - 143 mcg/mg creatinine
Citric acid, cis-aconitic acid, and isocitric acid are the first three metabolites in the Krebs Citric Acid energy production cycle, which operates in the mitochondria of your cells.
LEARN MOREKetoisovalerate
Optimal range: 0 - 0 mcg/mg creatinine
Alpha-Ketoisovalerate requires Vitamin B1, B5, lipoic acid, B2, and B3 (in descending order of significance) to be metabolized. As your food is broken down, specific compounds are formed at steps that require B vitamin assistance. a-Ketoisovalerateis one of these compounds. If these nutrients are insufficient, the keto acids may build up in the urine.
LEARN MOREKynurenate
Optimal range: 0 - 1.5 mcg/mg creatinine
Kynurenate is product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Your body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein.
LEARN MOREL-Lactate
Optimal range: 0.6 - 16.4 mcg/mg creatinine
L-Lactate is a product of muscle use, so it is constantly produced in normal daily activity.
LEARN MOREMalate
Optimal range: 0 - 3.1 mcg/mg creatinine
Malate is involved in the citric acid cycle (aka. Krebs cycle). The citric acid cycle is a series of reactions that occur in the mitochondrion to generate chemical energy that fuels the metabolism.
LEARN MOREMethylmalonate (Genova)
Optimal range: 0 - 2.3 mcg/mg creatinine
Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production.
LEARN MOREOrotate
Optimal range: 0 - 1.01 mcg/mg creatinine
Orotate is a sensitive marker of your liver’s capacity to convert toxic ammonia to non-toxic urea that you can excrete. That capacity can be increased by additional arginine. Ammonia toxicity can also be reduced by supplementation with α-ketoglutarate, magnesium, aspartic acid, and glutamic acid. Ammonia impairs brain function, causing difficulty with thinking, fatigue, headaches, and increased food sensitivities.
LEARN MOREp-Hydroxybenzoate
Optimal range: 0 - 1.8 mcg/mg creatinine
The presence of organic compounds such as p-Hydroxybenzoate in the urine may point towards significant dysbiosis (=impaired microbiota).
LEARN MOREp-Hydroxyphenylacetate
Optimal range: 0 - 34 mcg/mg creatinine
Associated with small intestinal bacteria overgrowth (SIBO) due to its production by C. di cile, C. stricklandii, C. lituseburense, C. subterminale, C. putrefaciens, and C. propionicum.
LEARN MOREp-Hydroxyphenyllactate
Optimal range: 0 - 0.66 mcg/mg creatinine
p-hydroxyphenyllactate is a marker of cell turnover. It is also a metabolite in tyrosine degradation and may be useful for studying disorders of tyrosine metabolism.
LEARN MOREPhenylacetate
Optimal range: 0 - 0.18 mcg/mg creatininePhenylpropionate
Optimal range: 0 - 0.06 mcg/mg creatinine
Phenylpropionate is a intestinal microbial balance marker. Phenylpropionate is formed from bacterial action on phenylalanine and it should only be present at very low levels.
LEARN MOREPicolinate
Optimal range: 2.8 - 13.5 mcg/mg creatinine
Picolinate is a neurotransmitter metabolism marker and is produced under inflammatory conditions.
LEARN MOREPyroglutamate (Genova)
Optimal range: 28 - 88 mcg/mg creatinine
Pyroglutamate (or Pyroglutamic acid) is an intermediate in the glutathione metabolism and a marker of glutathione deficiency.
LEARN MOREPyruvate (Genova)
Optimal range: 0 - 6.4 mcg/mg creatinine
Pyruvate feeds into the citric acid cycle & converts into acetyl CoA. Pyruvate is formed from carbohydrate via glucose or glycogen & secondarily from fats (glycerol) & glycogenic amino acids.
LEARN MOREQuinolinic acid (Quinolinate) (Genova)
Optimal range: 0 - 5.8 mcg/mg creatinine
Quinolinic acid is a neurotoxic substance produced by our own bodies and a metabolite of tryptophan.
LEARN MORESuberate
Optimal range: 0 - 4.6 mcg/mg creatinine
Suberate, Adipate, and Ethylmalonate elevations can indicate that you may need additional carnitine and/or vitamin B2 to assist your cells in converting fats into energy efficiently.
LEARN MORESuccinate
Optimal range: 0 - 20.9 mcg/mg creatinine
Succinate (or succinic acid) is an important metabolite that is involved in several chemical processes in the body.
LEARN MORESulfate
Optimal range: 690 - 2988 mcg/mg creatinine
Sulfate is associated with your body’s use of glutathione, an amino acid critical for removing toxins that is also a powerful antioxidant.
LEARN MORETricarballylate
Optimal range: 0 - 1.41 mcg/mg creatinine
Tricarballylate is produced by a strain of aerobic bacteria. It binds to magnesium which results in magnesium deficiency.
LEARN MOREVanilmandelate (Genova)
Optimal range: 1.2 - 5.3 mcg/mg creatinine
Vanilmandelate (VMA) and Homovanillate (HVA) are breakdown products from neurotransmitters involved in hormone and nerve impulse transmission, called catecholamines.
LEARN MOREXanthurenate (Genova)
Optimal range: 0 - 0.46 mcg/mg creatinine
Your body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein. Inadequate vitamin B6 is one factor that leads to increased concentrations of kynurenate and xanthurenate in urine.
LEARN MORE