Heart and Muscle Health
Blood and urine lab tests are used to find out your risk of heart and blood vessel disease. The results, along with your health history, help your health care team create the best plan of care for you.
Keeping your muscles healthy will help you to be able to walk, run, jump, lift things, play ... Healthy muscles let you move freely and keep your body strong.
ADMA
Optimal range: 0 - 100 ng/mL
ADMA/SDMA may be measured in individuals with multiple risk factors for the development of CVD.
One of the earliest manifestations of endothelial dysfunction is nitric oxide (NO) deficiency, which promotes atherosclerosis. Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), its structural isomer, are metabolites of L-arginine, an amino acid that is catalyzed to L-citrulline and NO by nitric oxide synthase (NOS).
Both ADMA and SDMA have distinct pathophysiologies and manifestations. ADMA is a competitive inhibitor of NOS thereby reducing NO production and promoting endothelial dysfunction. SDMA also interferes with NO production, but does so indirectly by reducing the cellular availability of arginine. ADMA is primarily cleared through enzymatic degradation in the bloodstream and its presence identifies subclinical cardiovascular disease (CVD). Conversely, SDMA is primarily excreted in the urine and identifies reduced renal function.
LEARN MOREAldolase
Optimal range: 3.3 - 10.3 ug/L
Aldolase is an enzyme that participates in glycolysis, which is the pathway for metabolizing glucose into energy. Elevated levels of aldolase in the blood occur in diseases of muscle including Duchenne muscular dystrophy, dermatomyositis, and polymyositis.
LEARN MORECK-BB
Optimal range: 0 - 0.001 %
There are three types of Creatine Kinase enzymes:
CK-MM, found mostly in skeletal muscles
CK-MB, found mostly in the heart muscle
CK-BB, found mostly in your brain. It's also found in smooth muscles such as the intestine or uterus.
A small amount of CK in the blood is normal. Higher amounts can mean a health problem. Depending on the type and level of CK found, it can mean you have damage or disease of the skeletal muscles, heart, or brain.
LEARN MORECK-MB
Optimal range: 0 - 3 %
Creatine Kinase is a type of protein that is mostly found in the skeletal muscle (CK-MM). 97 to 100% of Creatine Kinase are usually found in skeletal muscle. The other two types of Creatine Kinase are CK-MB (Creatine Kinase found in the heart muscle) and CK-BB (Creatine Kinase found in brain tissue).
There are three types of Creatine Kinase enzymes:
CK-MM, found mostly in skeletal muscles
CK-MB, found mostly in the heart muscle
CK-BB, found mostly in brain tissue
CK-MB isoenzymes level helps quantify the degree of myocardial infarction and the timing of onset of infarction.
This enzyme is also used to determine the effectiveness of thrombolytic therapy used for myocardial infarction.
This is found in cardiac and skeletal muscles. The cardiac muscle has 30%, and the skeletal muscle has 1% MB.
LEARN MORECK-MM
Optimal range: 97 - 100 %
Creatine Kinase is a type of protein that is mostly found in the skeletal muscle (CK-MM). 97 to 100% of Creatine Kinase are usually found in skeletal muscle. The other two types of Creatine Kinase are CK-MB (Creatine Kinase found in the heart muscle) and CK-BB (Creatine Kinase found in brain tissue).
There are three types of Creatine Kinase enzymes:
CK-MM, found mostly in skeletal muscles
CK-MB, found mostly in the heart muscle
CK-BB, found mostly in brain tissue
A small amount of CK in the blood is normal. Higher amounts can mean a health problem. Depending on the type and level of CK found, it can mean you have damage or disease of the skeletal muscles, heart, or brain
LEARN MORECreatine kinase
Optimal range: 24 - 204 U/L
This test measures the amount of creatine kinase (CK) in the blood. CK is a type of protein, known as an enzyme. It is mostly found in your skeletal muscles and heart, with lesser amounts in the brain. Skeletal muscles are the muscles attached to your skeleton. They work with your bones to help you move and give your body power and strength. Heart muscles pump blood in and out of the heart.
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Creatine phosphokinase (CPK)
Optimal range: 29 - 168 U/L
Creatine phosphokinase (CPK) is an enzyme in the body. It is found mainly in the heart, brain, and skeletal muscle.
This test may be used to:
- Diagnose heart attack
- Evaluate cause of chest pain
- Determine if or how badly a muscle is damaged
- Detect dermatomyositis, polymyositis, and other muscle diseases
- Tell the difference between malignant hyperthermia and postoperative infection
LEARN MORESDMA
Optimal range: 73 - 135 ng/mL
ADMA/SDMA may be measured in individuals with multiple risk factors for the development of CVD.
SDMA is primarily excreted in the urine and identifies reduced renal function.
One of the earliest manifestations of endothelial dysfunction is nitric oxide (NO) deficiency, which promotes atherosclerosis. Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), its structural isomer, are metabolites of L-arginine, an amino acid that is catalyzed to L-citrulline and NO by nitric oxide synthase (NOS).
Both ADMA and SDMA have distinct pathophysiologies and manifestations. ADMA is a competitive inhibitor of NOS thereby reducing NO production and promoting endothelial dysfunction. SDMA also interferes with NO production, but does so indirectly by reducing the cellular availability of arginine. ADMA is primarily cleared through enzymatic degradation in the bloodstream and its presence identifies subclinical cardiovascular disease (CVD). Conversely, SDMA is primarily excreted in the urine and identifies reduced renal function.
LEARN MORETroponin
Optimal range: 0 - 0.06 ng/mL
Troponin proteins are released when the heart muscle has been damaged, such as occurs with a heart attack. The more damage there is to the heart, the greater the amount of troponin T and I there will be in the blood.
LEARN MORETroponin T, High Sensitivity
Optimal range: 0 - 13 ng/liter
Troponin T, High Sensitivity (hs-TnT) is an independent prognostic marker that aids in the diagnosis of myocardial infarction (MI) in an acute setting (>22 ng/L for males and >14 ng/L for females), and there is literature supporting its use to assess relative risk for cardiovascular disease (CVD) and adverse cardiovascular events (≥6 ng/L for males and females).
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