These antibodies target a human body’s produced enzyme called cytochrome P450 2D6, a protein found primarily in liver cells which catalyze many reactions involved in drug metabolism. The development of the LKM antibodies is strongly associated with type 2 autoimmune hepatitis.
What is Autoimmune hepatitis?
Autoimmune hepatitis is an acute or chronic inflammation of the liver that can lead to liver cirrhosis and, in some cases, to liver failure. Just why the body turns against itself is unclear, but researchers think autoimmune hepatitis could be caused by the interaction of genes controlling immune-system function and exposure to particular viruses or drugs.
Although adults can develop type 2 autoimmune hepatitis, it’s most common in children and young people. Other autoimmune diseases may also accompany this type of autoimmune hepatitis.
Signs and symptoms include:
Yellowish skin and eyes (jaundice)
Itching, sometimes over the whole body
Lack of appetite
Nausea, vomiting, or both
Belly (abdominal) pain or discomfort
Broken blood vessels on the skin, often in a “spider” shape
Risk Factors may include:
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