Array 5 Multiple Autoimmune Reactivity Screen
Serum
Performed by: Cyrex Laboratories
Predictive Autoantibody Testing: Early Detection of Autoimmune and Tissue Damage
This test measures predictive autoantibodies, including some that may appear up to 10 years before clinical symptoms. It provides a cost-effective and efficient evaluation of potential tissue damage across multiple organs, empowering early diagnosis and intervention for autoimmune and related conditions.
Clinical Applications:
- Early Autoimmune Detection: Measures predictive antibodies that can emerge up to a decade before disease onset.
- Comprehensive Tissue Health Assessment: Efficiently and economically identifies possible damage to multiple organs.
Recommended for:
- Patients With Diagnosed Autoimmune Disorders: These individuals are at a higher risk of developing additional autoimmune conditions.
- Individuals With Chronic Increased Intestinal Permeability ("Leaky Gut"): A known gateway for environmentally triggered autoimmune diseases.
Antigens Tested:
IgG Markers:
- Thyroglobulin
- Thyroid Peroxidase (TPO)
Autoantibodies:
- Islet Cell Antigen (IA-2)
- Glutamic Acid Decarboxylase 65 (GAD 65)
Combined IgG + IgA Markers:
- Parietal Cell + ATPase
- Intrinsic Factor
- ASCA + ANCA
- Tropomyosin
- 21 Hydroxylase (Adrenal Cortex)
- Myocardial Peptide
- Alpha-Myosin
- Phospholipid
- Platelet Glycoprotein
- Ovary/Testis*
- Fibulin
- Collagen Complex
- Arthritic Peptide
- Osteocyte
- Cytochrome P450 (Hepatocyte)
- Myelin Basic Protein
- Asialoganglioside
- Alpha + Beta Tubulin
- Cerebellar
- Synapsin
By offering predictive autoantibody testing alongside targeted antigen panels, this test empowers individuals and healthcare providers to take a proactive approach to autoimmune health and organ function.
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Biomarkers included in this panel:
ANTIBODIES ASSOCIATED WITH*: *This test by itself is not diagnostic for any condition or disease - Addison’s Disease - Adrenal Autoimmunity - Adrenal Insufficiency - Atrophic Gastritis - Autoimmune Endocrine Disorders - Diabetes Insipi
Learn moreANTIBODIES ASSOCIATED WITH: This test by itself is not diagnostic for any condition or disease Alcoholic Liver Disease Demyelinating Disease Graves’ Disease Hashimoto’s Thyroiditis Infectious agent exposure PANDAS / ANDAS / OCD
Learn moreANTIBODIES ASSOCIATED WITH: This test by itself is not diagnostic for any condition or disease Alcoholic Liver Disease Demyelinating Disease Graves’ Disease Hashimoto’s Thyroiditis Infectious agent exposure PANDAS / ANDAS / OCD
Learn moreFunction: Myosin, the major contractile protein, converts chemical energy into mechanical force through hydrolysis of ATP. a-Myosin is almost exclusively expressed in cardiac tissue. Antibodies Appear: - Autoimmune Myocarditis [3] - Dilat
Learn moreFunction: Arthritic peptide, glucose-6-phosphate isomerase, is an endogenous molecule associated with joints. This cytoplasmic enzyme catalyzes the second step of glycolysis and is found at low levels in serum. Arthritic peptide can stimulate KRN
Learn moreFunction: Saccharomyces cerevisae, baker’s yeast, contains Chl1p, a putative helicase with human homologs (antiSaccharamyces cerevisae antibody – ASCA), which is required for DNA repair, recombination, transcriptional silencing and agi
Learn moreGM1 is exposed at the surface of spinal motor neurons, and in the peripheral nerves, it is limited to the node and paranodal region. Low levels of antibodies can be found in normal individuals and in patients with certain autoimmune disorders, howeve
Learn moreAsialoganglioside is exposed at the surface of spinal motor neurons, and in the peripheral nerves, it is limited to the node and paranodal region. Low levels of antibodies can be found in normal individuals and in patients with certain autoimmune dis
Learn moreFunction: Cerebellum is the part of the brain controlling movement and balance. Inside the cerebellar cortex there are large neurons called Purkinje’s cells. The Cerebellar antibodies test measures antibodies against the cerebellum Purkinje&
Learn moreFunction: Cerebellum is the part of the brain controlling movement and balance. Inside the cerebellar cortex there are large neurons called Purkinje’s cells. The Cerebellar antibodies test measures antibodies against the cerebellum Purkinje&
Learn moreFunction: Collagen is a group of proteins found in the flesh and connective tissues. The most abundant protein of the human body, Collagen is the main component of connective tissue. Collagen is found in tissues such as tendon, ligament and skin,
Learn moreFunction: The cytochrome P450 (CYP) superfamily is a large and diverse group of enzymes, most of which catalyze the oxidation of organic substances. A hepatocyte is a cell of the main tissue of the liver. Hepatocytes make up 70-80% of the liver&rs
Learn moreANTIBODIES ASSOCIATED WITH: This test by itself is not diagnostic for any condition or disease Atherosclerotic Lesions Osteoarthritis BODY TISSUE: Joint
Learn moreFunction: Glutamic Acid Decarboxylase (GAD), a neuronal protein, is an enzyme responsible for the conversion of the excitatory neurotransmitter glutamate to the inhibitory neurotransmitter g-aminobutyric acid (GABA). GAD is also expressed by pancr
Learn moreANTIBODIES ASSOCIATED WITH*: *This test by itself is not diagnostic for any condition or disease Battan Disease Celiac Disease Cerebellar Ataxia Non-Celiac Gluten Sensitivity Polyendocrine Autoimmune Syndrome Stiff-Person Syndrome Type 1 Di
Learn moreIdentification of individuals at risk of type 1 diabetes (including high-risk relatives of patients with diabetes).
Learn moreAssociated with: - Insulinoma - Type 1 Diabetes - Unexplained Hypoglycemia - Latent Autoimmune Diabetes of Adults
Learn moreIntrinsic factor is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 within distal ileum. Clinical Significance: Autoantibodies against Intrinsic Factor are considered highly specif
Learn moreFunction: Myelin is the protective sheath surrounding nerves. Myelin basic protein (MBP) is believed to be important in the process of myelination, the building of myelin sheaths. Thus, MBP is often a target in the demyelination process in various
Learn moreFunction: Myelin is the protective sheath surrounding nerves. Myelin basic protein (MBP) is believed to be important in the process of myelination, the building of myelin sheaths. Thus, MBP is often a target in the demyelination process in various
Learn moreFunction: Myocardial Peptides make up heart structure tissues. Antibodies Appear: - Acute Rheumatic Fever [6] - Autoimmune Myocarditis [1, 2] - Heart Disease [1, 2, 3] - Heart Trauma [3, 4, 6] - Rheumatic Heart Disease [6]
Learn moreFunction: A star-shaped cell, an osteocyte is an abundant cell found in compact bone. Cytoplasmic extensions, which occupy canals called canaliculi, network osteocytes. Canaliculi are used by osteocytes for the exchange of nutrients and waste thro
Learn moreANTIBODIES ASSOCIATED WITH: This test by itself is not diagnostic for any condition or disease Autoimmune Endocrine Disorders Autoimmune Polyendocrine Syndrome Type 1 Hypogonadism Premature Menopause Premature Ovarian Failure BODY TISSUE:
Learn moreAssociated with: - Gastric Autoimmunity - Chronic Atrophic Gastritis - Pernicious Anemia
Learn moreFunction: Phospholipids are a class of lipids that are a major component of all cell membranes. They play a role in the formation of lipid bilayers. Most phospholipids contain a diglyceride, a phosphate group, and a simple organic molecule such as
Learn morePlatelet Glycoprotein
ANTIBODIES ASSOCIATED WITH: This test by itself is not diagnostic for any condition or disease Arterial Thrombosis Autoimmune Thrombocytopenia Cardiovascular Disease Coronary Artery Disease Systemic Lupus Erythematosus (SLE) BODY TISSUE:
Learn moreFunction: Synapsin I, also known as phosphosynaspin I, is a major immunoreactive protein found in most neurons of the central and peripheral nervous systems. It is a member of a group of neuronal phosphoproteins involved in the regulation of neuro
Learn moreFunction: Synapsin I, also known as phosphosynaspin I, is a major immunoreactive protein found in most neurons of the central and peripheral nervous systems. It is a member of a group of neuronal phosphoproteins involved in the regulation of neuro
Learn moreFunction: Thyroglobulin (Tg) is a glycoprotein formed by two identical subunits. Tg is synthesized in thyrocytes and released into thyroid follicles where it is most abundant. Tg plays the main role in coupling of iodinized tyrosine residues to fo
Learn moreFunction: Thyroid peroxidase (TPO) is an enzyme expressed mainly in the thyroid that frees iodine for its addition onto thyroglobulin tyrosine residues for the production of thyroxine (T4) or triiodothyronine (T3), thyroid hormones. Some TPO a
Learn moreFunction: Thyroid peroxidase (TPO) is an enzyme expressed mainly in the thyroid that frees iodine for its addition onto thyroglobulin tyrosine residues for the production of thyroxine (T4) or triiodothyronine (T3), thyroid hormones. Some TPO antib
Learn moreAssociated with: • Ulcerative Colitis • Colon Autoimmunity • Inflammatory Bowel Disease Tropomyosin is a cytoskeletal microfilamental protein that regulates actin mechanics. Tropomyosin plays an important role in muscle c
Learn more