Small Intestinal Bacterial Overgrowth (SIBO)

What is small intestinal bacterial overgrowth (SIBO)?

SIBO is the accumulation of excessive amount of gut bacteria in the small intestine (at least 100,000 bacteria per ml of fluid). While bacterium naturally exist throughout the digestive tract, with highest concentrations of bacteria in the colon, a healthy individual should have relatively low levels of bacteria present in the small intestine. Any condition which impairs the normal transit or motion of the small intestine can increase the likelihood of getting SIBO, including lack of adequate stomach acid, damage to the intestine by toxins, or a decrease in the speed at which the small intestine transfers waste to the colon. In the U.S., some research studies have demonstrated that up to 80% of the IBS population, or 36 million individuals, suffer from SIBO.

What is the small bowel?

The small bowel, also known as the small intestine, is the part of the gastrointestinal tract that connects the stomach with the colon. The main purpose of the small intestine is to digest and absorb food into the body. The small intestine is approximately 21 feet in length.

What is a hydrogen and methane breath test for small intestinal bacterial overgrowth?

The Hydrogen and Methane Breath Test for SIBO is a non-invasive diagnostic tool to identify SIBO, and can be administered in the comfort of a patient’s own home. Patients are given a substrate solution to drink, which is a mixture of water and a carbohydrate substrate (lactulose or glucose). After drinking the substrate solution, the patient will collect a series of breath samples by simply breathing into a test tube using a straw. In a healthy individual, one would not expect to see any hydrogen or methane in the breath samples for approximately 90 minutes – 2 hours, the approximate time it would take for the substrate to travel to the small intestine to the colon where, in a healthy system, the substrate would be fed upon by bacteria, thus releasing the hydrogen and methane gas. After ingesting a substrate solution, the patient collects breath samples every 15 minutes over a 2 hour and 15 minute (135 minutes) period. During the hydrogen and methane breath test for SIBO, the presence of elevated levels of hydrogen or methane gas, or both, identified within 90 minutes of ingesting the substrate solution provides evidence of bacteria in the upper region of the digestive tract, i.e. at the level of the small intestine. This excessive build up bacteria is often diagnosed as SIBO. Our SIBO breath test can be administered in-office or in the comfort of the patient’s own home.

Biomarkers included in this panel:

Peak Hydrogen (H2) Production

The marker “Hydrogen increase over baseline by 90 minutes” is a key diagnostic indicator, used to identify excessive hydrogen gas production caused by bacterial fermentation in the small intestine. Normally, hydrogen is produced in minima

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Peak Methane (CH4) Production

Peak Methane (CH4) Production is a critical marker in NutriPATH’s 2-Hour SIBO Breath Test, used to detect methane-producing microbes in the small intestine, particularly methanogenic archaea such as Methanobrevibacter smithii. Unlike hydrogen,

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Small Intestinal Bacterial Overgrowth (SIBO)

Biomarkers included in this panel:

Peak Hydrogen (H2) Production

Peak Methane (CH4) Production

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