Performed by: LabCorp

What is the Lupus Anticoagulant Comp panel?

The Lupus Anticoagulant Comp (Comprehensive) panel is a specialized blood test used to detect lupus anticoagulants—a type of autoantibody that interferes with the body’s normal blood clotting process. Despite the name, lupus anticoagulants are not related to lupus exclusively and do not prevent clotting—in fact, they can increase the risk of abnormal blood clots (thrombosis).

Why is this test ordered?

Your doctor may order this panel if you have experienced:

Unexplained blood clots (deep vein thrombosis or pulmonary embolism)
Multiple miscarriages or pregnancy complications
Prolonged PTT (partial thromboplastin time) on routine labs
Suspected antiphospholipid syndrome (APS)
Autoimmune conditions like systemic lupus erythematosus (SLE)

What does the panel include?

Labcorp’s Lupus Anticoagulant Comp panel typically includes:

dRVVT Screen and Confirm (Dilute Russell Viper Venom Test)
PTT-LA (Partial Thromboplastin Time with LA-sensitive reagent)
Hexagonal Phase Phospholipid Neutralization Test

Each component is designed to detect the presence and activity of lupus anticoagulant antibodies by evaluating how your blood clots under different conditions.

What do the results mean?

Positive or Elevated Results: May indicate the presence of lupus anticoagulants and support a diagnosis of antiphospholipid syndrome. This raises your risk of developing blood clots or pregnancy complications.
Negative or Normal Results: Suggest lupus anticoagulants are not present or are below the detectable threshold.

Sometimes results may be equivocal, requiring repeat testing—especially if you’re ill or taking blood thinners, which can affect accuracy.

Next steps

If your results are abnormal, your healthcare provider may:

Repeat the test in 12 weeks to confirm persistence (required for APS diagnosis)
Order additional antibody tests (like anti-cardiolipin or beta-2 glycoprotein I)
Assess your personal and family history of clotting or autoimmune disease
Adjust medications or recommend lifestyle changes to reduce clotting risk

Bottom Line

The Lupus Anticoagulant Comp panel is an essential diagnostic tool for identifying clotting risks linked to autoimmunity. It plays a critical role in managing conditions like antiphospholipid syndrome and ensuring appropriate preventative care.

Lupus Anticoagulant Comp

Performed by: LabCorp

What is the Lupus Anticoagulant Comp panel?

Why is this test ordered?

What does the panel include?

What do the results mean?

Next steps

Bottom Line

Biomarkers included in this panel:

Dilute Prothrombin Time (dPT)

dPT Confirm Ratio

dRVVT

PTT-LA

Thrombin Time

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