Anti-Smith Antibody

Immune System

A healthy result should fall into the range 0 - 0 Units.

AKA: Anti-Smith Antibody / Sm / Anti-Sm antibodies / Smith (ENA) Antibody, IgG

The Anti-Smith Antibody targets your body’s own proteins and is found almost exclusively in people with lupus. Though not all people with lupus have this antibody (only around 30%), those who do usually receive a diagnosis of lupus. Anti-Smith antibody is more common in blacks and Asians with SLE (around 60%) than in whites with SLE.

- It is occasional also present in mixed connective-tissue disease (MCTD).

- Anti-Smith antibody levels are elevated in 30% of SLE cases and 8% of MCTD cases

- They almost never occur in healthy individuals or patients with other diseases.

- High levels persist even after anti-DNA levels have returned to the normal range. This is useful when testing a patient with decreased signs or symptoms of SLE.


– What is the clinical significance of anti-Sm antibodies in systemic lupus erythematosus? A comparison with anti-dsDNA antibodies and C3. [L]

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