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Home › Research › Immune System: Chromatin
Immune System

Chromatin

Optimal result: 0 – 99 units/ml
By Healthmatters Editorial Team
Peer-reviewed sources

Antichromatin antibodies are found in 50% to 90% of SLE patients and have been linked with proteinuria in SLE patients.

Patients with antichromatin antibodies had a 1,63-fold higher prevalence of lupus nephropathy, than those without these antibodies (88,09% vs. 53,84%). [L]

Help to diagnose drug-induced lupus (DIL) and systemic lupus erythematosus (SLE). Antibodies to both chromatin and histones have been found in patients with procainamide-induced lupus; however, patients with lupus induced by drugs such as quinidine, penicillamine, methyldopa, and acebutolol have antibodies to chromatin but not antihistone. Antichromatin antibodies are found in 50% to 90% of SLE patients and have been linked with proteinuria in SLE patients.

Antichromatin antibodies are more sensitive than anti-dsDNA antibodies in detecting active SLE.

Help to diagnose drug-induced lupus (DIL) and systemic lupus erythematosus (SLE). Antibodies to both chromatin and histones have been found in patients with procainamide-induced lupus; however, patients with lupus induced by drugs such as quinidine, penicillamine, methyldopa, and acebutolol have antibodies to chromatin but not antihistone. Antichromatin antibodies are found in 50% to 90% of SLE patients and have been linked with proteinuria in SLE patients.

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Chromatin
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