Tickborne (Vibrant Wellness)

A test for detection of tickborne disease and other tickborne diseases.

Tickborne diseases can be acquired throughout the United States from a variety of ticks, which carry and pass on different microorganisms to humans and animals. Symptoms may be generic and have overlap with other conditions, and therefore, be difficult to associate with a tickborne disease.

Tickborne disease symptoms and disease progression can also often be more severe in the elderly and immunocompromised.

Symptoms Associated with Tickborne Diseases Include:

  • Fever and/or chills
  • headache
  • Bell’s palsy
  • neck stiffness
  • fatigue
  • muscle or joint aches/pains
  • GI symptoms : nausea, vomiting, diarrhea
  • rash
  • loss of appetite
  • weight loss
  • change in cognitive or psychological status
  • anemia
  • enlarged, tender lymph nodes
  • painful abdomen
  • dizziness or shortness of breath
  • numbness or weakness in limbs

Tickborne diseases have more than doubled in 13 years and are 77% of all vector-borne disease reports

  • The most common tickborne diseases (TBDs) in the United States are Anaplasmosis, Babesiosis, Bartonella infections, Ehrlichiosis, Rickettsiosis, Rocky Mountain spotted fever (RMSF), and Lyme disease
  • Lyme Disease accounts for the majority (82%) of all tickborne disease cases

Ticks usually need between 24 and 72 hours to effectively transmit any diseases they are carrying and, if found in time on the host, can be removed before they transmit infectious microorganisms to the host.

Because many symptoms of tickborne diseases are generic or mimic other conditions, these diseases often go undiagnosed for months, increasing the suffering and disease progression of the patient.

Interpretation:

By CDC criteria Lyme IgM is reported positive if VlsE1 or C6 peptide or WCS (Whole cell sonicate) is positive and two of the following three antigens are positive:

23-25kDa,

39kDa

and 41kDa.

In the alternate criteria IgM is reported positive if VlsE1 or C6 peptide or WCS (Whole cell sonicate) is borderline or positive and any two of the following antigens are borderline or positive:

23-25kDa,

31kDa,

34kDa,

39kDa,

41kDa

and 83-93kDa. 

Similarly, by CDC criteria Lyme IgG is reported positive if VlsE1 or C6 peptide or WCS (Whole cell sonicate) is positive and any five of the following ten antigens are positive:

18kDa,

23-25kDa,

28kDa,

30kDa,

39kDa,

41kDa,

45kDa,

58kDa,

66kDa

and 83-93kDa.

In the alternate criteria IgG is reported positive if VlsE1 or C6 peptide or WCS is borderline or positive and two of the following antigens are borderline or positive:

18kDa,

23-25kDa,

28kDa,

30kDa,

39kDa,

41kDa,

45kDa,

58kDa,

66kDa

and 83-93kDa.

Babesia microti WCS - IgG

Optimal range: 0 - 10 Units

Babesia microti, the primary agent of human babesiosis in the United States.

The B. microti life cycle involves two hosts, which includes a rodent, primarily the white-footed mouse, Peromyscus leucopus, and a tick in the genus, Ixodes, the same tick species that vectors Lyme disease. Cases of babesiosis caused by B. microti occur in southern New England and the northern Midwest. Early clinical manifestations are intermittent fevers accompanied by fatigue and malaise, headache, chills, and myalgias. Nausea, vomiting, reduced appetite, and depression can also occur. Coinfection with Lyme disease or anaplasmosis may complicate the clinical presentation and predispose the patient to more severe disease.

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Bartonella vinsonii - IgM

Optimal range: 0 - 10 Units

Bartonella vinsonii, a member of the genus Bartonella, is a proteobacterium that is the causative agent of Bartonellosis. The pathogen has been isolated in immunocompetent patients with endocarditis, arthritis, neurological disease and neoplasia . From animal studies it appears that Bartonella henselae is well adapted to felines or cats while Bartonella vinsonii is well adapted to canines or dogs though each species can infect both.

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Borrelia afzelii OspA - IgG

Optimal range: 0 - 10 Units

Borrelia afzelii is a species of Borrelia, a bacterium that can infect various species of vertebrates and invertebrates. B. afzelii and B. garinii are the primary causes of Lyme disease in Europe and Asia.

Coinfection by this Borrelia species with one or more pathogens can occur, carried by the vector, which appears to be in most cases the tick. In Europe the related genospecies Borrelia afzelii is associated with both EM and acrodermatitis chronica atrophicans (ACA), and several European studies have found compelling evidence for B. afzelii infection in patients with morphea.

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Borrelia burgdorferi 297 strain WCS - IgM

Optimal range: 0 - 10 Units

Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.

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Borrelia burgdorferi C6 peptide - IgM

Optimal range: 0 - 10 Units

Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.

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Borrelia burgdorferi p31 (OspA) - IgG

Optimal range: 0 - 10 Units

Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.

Outer surface protein A (OspA) is one of the major proteins in the outer membrane of this B. burgdorferi. A vaccine based OspA was approved by the FDA in 1998. Individuals vaccinated subcutaneously showed approximately 76% protection agains B. burgdorferi infection after receiving three vaccine doses; however, the human vaccine was removed from the market later.

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Borrelia burgdorferi p34 (OspB) - IgG

Optimal range: 0 - 10 Units

Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.

Outer surface protein B (OspB) is one of the major proteins in the outer membrane of this B. burgdorferi. OspB was found to be critical for B. burgdorferi adherence and survival within Ixodes ticks.

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Borrelia burgdorferi p66 - IgG

Optimal range: 0 - 10 Units

Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.

B. burgdorferi p66 is an outer membrane spanning protein Oms66. It is proven to be an integral membrane porin because liposome-reconstituted P66 displayed channel-forming activity in planar lipid bilayer assays. P66 has also been shown to function as an adhesin that binds the mammalian cell receptors, B3 chain and B1 chain integrins.

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Borrelia burgdorferi p66 - IgM

Optimal range: 0 - 10 Units

Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.

B. burgdorferi p66 is an outer membrane spanning protein Oms66. It is proven to be an integral membrane porin because liposome-reconstituted P66 displayed channel-forming activity in planar lipid bilayer assays. P66 has also been shown to function as an adhesin that binds the mammalian cell receptors, B3 chain and B1 chain integrins.

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Borrelia burgdorferi VlsE1 - IgG

Optimal range: 0 - 10 Units

Borreliella burgdorferi is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. Lyme disease is a zoonotic, vector-borne disease transmitted by the Ixodes tick. Clinical presentation of Lyme disease is known for the characteristic bull's-eye rash (also known as erythema migrans) but can also include myocarditis, cardiomyopathy, arrythmia, arthritis, arthralgia, meningitis, neuropathies, and facial nerve palsy depending on the stage of infection.

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Borrella turicatae - IgM

Optimal range: 0 - 10 Units

HHV-7 - IgG

Optimal range: 0 - 10 Units

Human herpesvirus 7 is a herpes family virus that can stay in your body for life usually in a dormant state. It is ubiquitous worldwide and nearly 70% of all children will be exposed to the virus by the age of 4. DNA of the virus has been found in the CD4+ T cells of healthy adults which is indicative of the latency.

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Parovirus B19 VLP VP1/Vp2 Co Capsid - IgG

Optimal range: 0 - 10 Units

Lyme disease and Parovirus B19 infections produce arthritis, rashes, and a systemic illness that may be thought to represent a chronic rheumatic disease. Cases of co infections have also been reported in literature. Additionally, it has been shown to be a good candidate for differential diagnosis in cases of arthopathy where Lyme disease has been suspected.

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Rickettsia typhi Surface antigen - IgG

Optimal range: 0 - 10 Units

Rickettsia typhi is the etiological agent of murine typhus. R. typhi is transmitted primarily by the rat flea, Xenopsylla cheopis. Lice and mites can be potential vectors and rodents, shrews, opossums, cats can be reservoir. The clinical manifestations of murine typhus are usually less severe than those of epidemic typhus and includes persistent headache, a high-grade fever, and a cutaneous rash predominating on the trunk. Murine typhus usually takes a prolonged incubation period and the characteristic rash is occasionally absent. An antibody response is usually detected only after 10 days from the onset of systemic symptoms, and antibody titers reach a peak after 3 to 4 weeks or later if an antibiotic therapy has been administered.

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Toxoplasma gondii MIC3 - IgG

Optimal range: 0 - 10 Units

Toxoplasma gondii is a protozoan parasite that infects most species of warm-blooded animals, including humans, and causes the disease toxoplasmosis. Tick based transmission has been increasingly considered and evidence indicates that T. gondii could be a potentially unrecognized tick-borne pathogen spreading toxoplasmosis . The parasite forms cysts that can affect almost any part of the body often your brain and muscle tissue of different organs, including the heart. The immune system keeps the parasites in check in an inactive state however, if it is weakened by disease or certain medications, the infection can be reactivated, leading to serious complications.

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