This test is used as an aid in the diagnosis of certain autoimmune thrombotic disorders, such as antiphospholipid syndrome (aPS). Antibodies to PS/PT correlate with the presence of lupus anticoagulants (LA) and this test may be useful in cases with difficult LA test interpretation. This assay may also assist in the determination of risk for thrombosis as well as obstetric complications in patients with antiphospholipid antibodies.
What is APS?
The antiphospholipid syndrome (APS) is a unique form of acquired autoimmune thrombophilia characterized by recurrent arterial and/or venous thrombosis, pregnancy-related complications (including miscarriages, fetal deaths, premature births, and preeclampsia), and the persistent presence of antiphospholipid antibodies (aPL).
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IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and risk for obstetric antiphospholipid syndrome (APS).
Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies.
Isolated presence of IgM or IgG antibodies to aPS may have questionable clinical significance for APS and/or SLE.
If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.
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14.3.3 ETA PROTEIN, Acetylcholine Receptor (AChR) Antibody, Activated partial thromboplastin time (APTT), Alpha 2-Macroglobulins, Qn, Alpha Melanocyte Stimulating Hormone, ANA SCREEN A, ANA SCREEN B, ANA SCREEN, IFA, ANA Screen, IFA (Positive, Negative), ANA titer, Anti-C1Q Ab, IgG (RDL), Anti-DBL-Strand DNA Ab, Anti-dsDNA (Double-stranded) Ab by Farr method (RDL), Anti-dsDNA ab (Farr Assay), Anti-Smith Antibody, Anticardiolipin Ab, IgM, Anticardiolipin Ab,IgA,Qn, Anticardiolipin Ab,IgG,Qn, Antinuclear Antibodies (ANA) Screen, Reflex ANA IFA dsDNA Antibodies, Antinuclear Antibodies Direct (ANA Direct), Antiphosphatidylserine IgA, Antiphosphatidylserine IgG, Antiphosphatidylserine IgM, Baski sleepy, C1 Esterase Inhibitor, Func, C1 Esterase Inhibitor, Serum, C3A Desarg Fragment, C4a Level by RIA, CARDIOLIPIN AB (IGA), CARDIOLIPIN AB (IGG), CARDIOLIPIN AB (IGM), Carnitine Esters, Carnitine, Free, Carnitine, Total, CCP Antibodies IgG/IgA, Centromere, Chromatin, Coccidioides Ab by CF, Coccidioides Ab, IgG, EIA, Coccidioides Ab, IgM, EIA, Complement C3, Complement C3a, Complement C4, Serum, Complement C4a, Complement Component C1Q, Complement, Total (CH50), Complement, Total (CH50) / Quest, Cyclic Citrullinated Peptide Antibody, Dilute Russell's viper venom time (dRVVT), Diphtheria Antitoxoid Antibody, DNA AB Double Stranded Titer, DNA Double-Stranded Ab, IgG, DRVVT SCREEN, ds-DNA Antibody, IgG, dsDNA, ENA to Smith (Sm) Antibody, Eosinophil Cationic Protein (ECP), Erythrocyte Sedimentation Rate (ESR), Esterified/Free Ratio, F004-IgE Wheat, Free Kappa Lt Chains, Serum, Free Lambda Lt Chains, Serum, Gastrin, GlycA, Hemoglobin A2 (Quant), HISTAMINE RELEASE (CHRONIC URTICARIA), Histamine, Plasma, Histone, HLA-B27 (Human Leukocyte Antigen B27), Human Transforming Growth Factor Beta 1 (TGF-b1), IGE ANTIBODY (ANTI IGE IGG), Immature Grans (Abs), Immature Granulocytes (%), Immunofixation Result, Serum, Immunoglobulin A, Qn, Serum, Immunoglobulin D, Quant, Serum, IMMUNOGLOBULIN E, Immunoglobulin E, Total, Immunoglobulin G, Qn, Serum, Immunoglobulin M, Qn, Serum, Influenza Type A Antibody Serum, Influenza Type B Antibody Serum, Interleukin-2, Serum, Interleukin-6, Jo 1 Antibodies, IgG, Serum, JO-1, Kappa/Lambda Ratio, Serum, Liver Kidney Mic IgG, Liver-Kidney Microsomal Antibodies, Lupus Anticoagulant, Measles Antibodies, IgG, Mumps Abs, IgG, PEP A2Glob, PHOSPHATIDYLETHANOLAMINE AB (IGA), PHOSPHATIDYLETHANOLAMINE AB (IGG), PHOSPHATIDYLETHANOLAMINE AB (IGM), PHOSPHATIDYLSERINE AB (IGA), PHOSPHATIDYLSERINE AB (IGG), PHOSPHATIDYLSERINE AB (IGM), Plasminogen Activator Inhibitor (PAI-1) AG, Prothrombin Fragment 1.2, Prothrombin Time (PT), Prothrombin Time (PT) INR, RA Latex Turbid, Reptilase Clotting Time, RF, IgA by EIA (RDL), RF, IgG by EIA (RDL), RF, IgM by EIA (RDL), Rheumatoid factor (RF), RNA Polymerase III Antibodies, RNP/Sm, Scl-70, SICKLE CELL SCRN, Sirolimus, Whole Blood, Sm, SM/RNP Antibody, Smith/RNP (ENA) Ab, IGG, Smooth Muscle Abs, IFA, SSA, SSB, ssDNA, Tacrolimus, Whole Blood, Tetanus Antitoxoid IgG Ab, TGF-b1, Thrombin time, Thrombin-Antithrombin TAT, Trans. Growth Fact. beta 1, Transforming Growth Factor beta, Plasma, Tryptase, Tumor Necrosis Factor, Varicella-Zoster Virus (VZV) DNA, Qualitative, Real-Time PCR, VEGF, Plasma, Von Willebrand Factor Antigen (vWF), vWF Activity