Lymphocyte Subset Panel 2

T-lymphocyte count assists in evaluating cellular immunocompetency.

Includes:

% CD3 (Mature T Cells), Absolute CD3+ Cells, % CD4, Absolute CD4+ Cells, % CD8, Absolute CD8+ Cells, CD4/CD8 Ratio, % CD19 (B Cells), Absolute CD19+ Cells, Absolute Lymphocytes

% CD19 (B Cells)

Optimal range: 6 - 29 %

The CD19 antigen (aka B-lymphocyte antigen CD19 or Cluster of Differentiation 19) plays an important role in clinical oncology. It’s a protein found on the surface of B-cells, a type of white blood cell.

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% CD3 (Mature T Cells)

Optimal range: 57 - 85 %

The proportion of all immune cells that are T cells. This figure is rarely used for making treatment decisions.

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% CD4

Optimal range: 30 - 61 %

The CD4 percentage (CD4%) is the percentage of white blood cells (lymphocytes) that are CD4 cells.

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% CD8

Optimal range: 12 - 42 %

The proportion of all T cells that are CD8 cells.

CD8 cells are also called cytotoxic T-lymphocytes. They help fight cancer and germs that live inside your cells (intracellular pathogens).

The CD8 percentage is sometimes more reliable than the absolute count of CD8 because it tends to vary less.

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Absolute CD19+ Cells

Optimal range: 110 - 660 cells/uL

The CD19 antigen (aka B-lymphocyte antigen CD19 or Cluster of Differentiation 19) plays an important role in clinical oncology. It’s a protein found on the surface of B-cells, a type of white blood cell.

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Absolute CD3+ Cells

Optimal range: 840 - 3060 cells/uL

CD3+ cells are all T-lymphocytes, which includes both CD4+ and CD8+ lymphocyte cells.

This figure is rarely used for making treatment decisions.

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Absolute CD4+ Cells

Optimal range: 490 - 1740 cells/uL

The CD4 cells are Helper T-cells expressing both CD3 and CD4.

CD4 T-cells levels are a criterion for categorizing HIV-related clinical conditions by CDC's classification system for HIV infection. The measurement of CD4 T-cell levels has been used to establish decision points for initiating P. jirovecii prophylaxis, antiviral therapy and to monitor the efficacy of treatment. The Public Health Service (PHS) has recommended that CD4 T-cell levels be monitored every 3 to 6 months in all HIV-infected persons.

During HIV infection, antiviral therapy is often initiated when the absolute CD4 count drops below 500 cells/µL. When the absolute CD4 count drops below 200 cells/µL, therapeutic prophylaxis against PCP and other opportunistic infections may be initiated. When the absolute CD4 count drops below 100 cells/µL, prophylaxis against Mycobacterium avium complex is recommended.

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Absolute CD8+ Cells

Optimal range: 180 - 1170 cells/uL

This figure is rarely used for making treatment decisions.

CD4 and CD8 are two types of white blood cells in your blood. CD4 cells are also called T-helper cells, T-suppressor cells, and cytotoxic T-cells. They help the body fight infections. CD8 cells are also called cytotoxic T-lymphocytes. They help fight cancer and germs that live inside your cells (intracellular pathogens).

The absolute number of all CD8 cells, which include both killer and suppressor T cells. The normal range for an HIV-negative person is 150 to 1,000. It is usually higher in a person with HIV.

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Absolute Lymphocytes

Optimal range: 850 - 3900 cells/uL

Lymphocytes are a type of white blood cell found in the body. They serve in several major roles in our immune system including identification of and response to invading organism. Your healthcare professional may assess lymphocyte levels when a white blood cell count came back as abnormal.

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CD4/CD8 Ratio

Optimal range: 0.86 - 5 Ratio

This test looks at the ratio of two important types of white blood cells in your blood.

Lymphocytes are a type of white blood cell in your immune system. This test looks at two of them, CD4 and CD8.

CD4 cells lead the fight against infections. CD8 cells can kill cancer cells and other invaders.

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CD57+ NK-cells (%)

Optimal range: 2 - 77 %

The CD57 test is offered in some clinical laboratories and is being used by some health practitioners to evaluate and follow patients diagnosed with chronic Lyme disease.

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CD57+ NK-cells (absolute)

Optimal range: 100 - 360 uL

The CD57 test is offered in some clinical laboratories and is being used by some health practitioners to evaluate and follow patients diagnosed with chronic Lyme disease.

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Lymph CD16&56 (NK) %

Optimal range: 7 - 14 %

CD1656 are an important NK (Natural killer) cell subset.

- NK cells are best known for killing virally infected cells, and detecting and controlling early signs of cancer. As well as protecting against disease, specialized NK cells are also found in the placenta and may play an important role in pregnancy.

- Natural killer T (NKT) cells represent a specialized T-cell population that is distinct from conventional T cells. They express an invariant T-cell receptor (TCR) that recognizes self and bacterial glycosphingolipid antigens presented by the MHC class I-like molecule, CD1d.

- Human natural killer (NK) cells can be subdivided in several subpopulations on the basis of the relative expression of the adhesion molecule CD56 and the activating receptor CD16. 

- NK cells serve an important role in host defense against viral infections, as well as tumor surveillance. They are also a component of the adaptive immune response through cytokine production.

- NK cell functions are governed by a balance between activating receptors and inhibitory receptors.

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Lymphocyte Absolute CD16&56 (NK) Count

Optimal range: 50 - 375 #/cumm

CD1656 are an important NK (Natural killer) cell subset.

- NK cells are best known for killing virally infected cells, and detecting and controlling early signs of cancer. As well as protecting against disease, specialized NK cells are also found in the placenta and may play an important role in pregnancy.

- Natural killer T (NKT) cells represent a specialized T-cell population that is distinct from conventional T cells. They express an invariant T-cell receptor (TCR) that recognizes self and bacterial glycosphingolipid antigens presented by the MHC class I-like molecule, CD1d.

- Human natural killer (NK) cells can be subdivided in several subpopulations on the basis of the relative expression of the adhesion molecule CD56 and the activating receptor CD16. 

- NK cells serve an important role in host defense against viral infections, as well as tumor surveillance. They are also a component of the adaptive immune response through cytokine production.

- NK cell functions are governed by a balance between activating receptors and inhibitory receptors.

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