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Research Biomarker Category Immune System Complement C4a

Complement C4a

Immune System

A healthy result should fall into the range 0 - 650 ng/mL.

The complement C4 test is one of the most frequently used complement component tests. Your doctor may order a complement C4 test if you’re experiencing symptoms that indicate an autoimmune disease. These symptoms may include:

  • extreme fatigue
  • muscle pain
  • joint pain
  • sudden, unexpected weight loss
  • muscle weakness
  • muscle paralysis

The complement C4 test is also sometimes used to monitor protein levels in people who have already been diagnosed with an autoimmune disease. Complement tests can provide doctors with valuable information about the effectiveness of current treatment for an autoimmune condition.

Complement C4a result calculator

insert the value from you Complement C4a test result.

What does it mean if your Complement C4a result is too low?

Lower-than-normal complement C4 values could indicate:

  • bacterial infections
  • hepatitis
  • malnutrition
  • rejection of a kidney transplant
  • systemic lupus erythematosus, which is an autoimmune disease affecting the skin, joints, kidneys, and other organs
  • lupus nephritis, which is a kidney disorder that often occurs as a result of systemic lupus erythematosus
  • cirrhosis, which indicates significant liver damage
  • glomerulonephritis, which is a type of kidney disease
  • hereditary angioedema, which is a rare but serious autoimmune disease that causes swelling in various parts of the body
  • Complement component activity varies throughout the body. People with rheumatoid arthritis, for example, may have high complement levels in their blood but low complement levels in their joint fluid.

What does it mean if your Complement C4a result is too high?

Higher-than-normal complement C4 values may be a sign of cancer or ulcerative colitis.



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