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Research GlycA
Immune System

GlycA

Serum
Optimal Result: 0 - 400 umol/L.

The GlycA test assesses a specific NMR signal, distinct from lipoprotein particle analysis, and is regarded as a potential marker of systemic inflammation, offering clinical utility comparable to high sensitivity C-reactive protein (hsCRP), fibrinogen, and other inflammation biomarkers. This NMR signal, termed "GlycA," originates from N-acetylglucosamine moieties on circulating glycoproteins' carbohydrate portions. The signal's magnitude reflects plasma protein glycosylation, not to be confused with nonenzymatic glycation related to glucose levels. GlycA predominantly represents glycosylated acute-phase proteins, like α1-acid glycoprotein, haptoglobin, α1-antitrypsin, α1-antichymotrypsin, and transferrin, which rise during inflammation. Therefore, GlycA is considered a global inflammation marker. Unlike discrete inflammation biomarkers, GlycA is a composite, providing a more stable measure with lower variability than hsCRP. While hsCRP requires serial measurements weeks apart for cardiovascular risk assessment, GlycA typically requires only one measurement, simplifying patient evaluation.

What does it mean if your GlycA result is too high?

Elevated levels of GlycA typically signify an increased presence of glycosylated acute-phase proteins in the bloodstream. These acute-phase proteins are released from the liver in response to inflammation or infection, and their glycosylation status can change during such immune responses. Therefore, elevated GlycA levels are considered indicative of systemic inflammation within the body.

Elevated GlycA levels may suggest the presence of underlying inflammation-related conditions, such as infections, autoimmune disorders, cardiovascular diseases, or chronic inflammatory conditions like rheumatoid arthritis.

Monitoring GlycA levels can be helpful in assessing the extent and persistence of inflammation, disease activity, and response to treatment.

It's important to note that while elevated GlycA levels can indicate the presence of inflammation, they do not provide a specific diagnosis of the underlying cause. Further clinical evaluation, including a detailed medical history, physical examination, and possibly additional tests, would be needed to identify the specific condition or disease associated with the elevated GlycA levels and to determine the appropriate treatment and management plan.

Frequently asked questions

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For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.

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Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.

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Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.

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We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.

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For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.

Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.

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Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.

Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.

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