ANA 12 Plus Profile (RDL)
Serum
Performed by: LabCorp
ANA 12 Plus Profile is reflexive and consists of the following:
Anti-Nuclear Ab (ANA)
If positive, reflexes to following 14 components:
- Anti-Cardiolipin Ab (IgG, IgA and IgM Isotypes)
- Anti-Centromere Ab
- Anti-Chromatin Ab
- Anti-dsDNA Ab by Farr
- Anti-La (SS-B) Ab
- Anti-Ro (SS-A) Ab
- Anti-Scl-70 Ab
- Anti-Sm
- Anti-TPO (Thyroid Microsomal Peroxidase) Ab
- Anti-U1 RNP
- C3 Complement
- C4 Complement
- Rheumatoid Factor by Turb
- Anti-CCP (Cyclic Citrullinated Peptide) Ab.
If ANA is positive, all tests listed are performed. If ANA is negative, an Anti-Ro (SS-A) Ab test is performed to catch the small percentage of ANA false negative results. ANA includes titer and pattern.
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Biomarkers included in this panel:
Anti-Cardiolipin antibodies (aCL) of the IgA class are autoantibodies that target cardiolipin, a phospholipid found in cell membranes. While less commonly discussed than their IgG and IgM counterparts, IgA anti-cardiolipin antibodies also play a role
Learn moreAnti-Cardiolipin antibodies (aCL) of the IgG class are a type of autoantibody directed against cardiolipin, a phospholipid present in cell membranes. These antibodies are significant in the diagnosis and management of autoimmune disorders, particular
Learn moreAnti-Cardiolipin antibodies (aCL) of the IgM class are autoantibodies directed against cardiolipin, a specific phospholipid in cell membranes. These antibodies are clinically significant, especially in the context of antiphospholipid syndrome (APS),
Learn moreAnti-CCP antibodies, or anti-cyclic citrullinated peptide antibodies, are autoantibodies frequently found in the blood of individuals with rheumatoid arthritis (RA). These antibodies target proteins that have been altered by a process called citrulli
Learn moreThe Anti-Centromere Antibody (ACA) test is an indirect immunofluorescence assay (IFA) used to detect autoantibodies that target centromere proteins. These antibodies are primarily associated with autoimmune connective tissue diseases, particularly li
Learn moreThe marker "Anti-Chromatin Ab, IgG (RDL)" refers to a specific type of blood test that detects antibodies called immunoglobulin G (IgG) that are directed against chromatin. Chromatin is a complex of DNA and proteins found in the nucleus of
Learn moreThe anti-double stranded DNA (anti-dsDNA) tests are used to help diagnose and monitor lupus, also called systemic lupus erythematosus or SLE, a chronic inflammatory autoimmune disorder in which the immune system mistakenly targets the body’s ow
Learn moreAnti-La (SS-B) Ab (RDL)
The Anti-La (SS-B) Antibody test is an important diagnostic tool for autoimmune disorders. This test specifically detects antibodies against the La (or SS-B) antigen, which is another key protein target in certain autoimmune diseases. The presence of
Learn moreAnti-Nuclear Antibody by IFA (RDL) refers to a diagnostic test that detects antinuclear antibodies (ANAs) in the blood. ANAs are a group of autoantibodies that target substances found in the nucleus of cells, and their presence is often associated wi
Learn moreAnti-Ro (SS-A) Ab (RDL)
The Anti-Ro (SS-A) Antibody test is a critical diagnostic tool in the assessment of autoimmune diseases. This test detects antibodies against the Ro/SS-A antigen, a protein implicated in the development of certain autoimmune conditions. The presence
Learn moreAnti-Scl-70 Ab (RDL)
Anti-Scl-70 antibodies, also known as Anti-Topoisomerase I antibodies, are a specific type of autoantibody primarily associated with systemic sclerosis (scleroderma), a chronic autoimmune disease. These antibodies target the enzyme topoisomerase I, w
Learn moreAnti-Sm Ab (RDL)
Anti-Sm antibodies (Anti-Smith antibodies) are autoantibodies that are strongly associated with systemic lupus erythematosus (SLE), a chronic autoimmune disease. The presence of Anti-Sm antibodies is considered a specific marker for SLE, as these ant
Learn moreAnti-TPO Ab (RDL)
Anti-TPO antibodies (Anti-Thyroid Peroxidase antibodies) are autoantibodies directed against thyroid peroxidase, an enzyme crucial for the production of thyroid hormones. These antibodies are a key marker in autoimmune thyroid diseases, particularly
Learn moreAnti-U1 RNP Ab (RDL)
The Anti-U1 RNP (Ribonucleoprotein) Antibody test is a specific diagnostic tool used in the evaluation of connective tissue diseases. This test detects antibodies against the U1 RNP, a component of a small nuclear ribonucleoprotein complex involved i
Learn moreC3 Complement (RDL)
C3 Complement, often simply referred to as C3, is a crucial protein component of the immune system's complement system. The complement system is a part of the innate immune response and plays a significant role in inflammation and defending again
Learn moreC4 Complement (RDL)
C4 Complement, an essential component of the immune system's complement pathway, plays a pivotal role in both innate and adaptive immunity. Similar to C3, C4 is involved in the activation of the complement system, particularly in the classical an
Learn moreHomogeneous Pattern
The Homogeneous pattern observed in an Antinuclear Antibody (ANA) test is a specific type of result that indicates the presence of antibodies in the blood that are reacting against components in the cell nucleus. This pattern is termed 'homogeneo
Learn moreThe Nuclear Dot Pattern, observed in Antinuclear Antibody (ANA) testing, is a distinctive immunofluorescence pattern characterized by discrete speckles or dots within the cell nucleus. This pattern emerges when specific autoantibodies in the patient&
Learn moreRheumatoid Factor (RF) is an autoantibody often found in individuals with autoimmune diseases, most notably rheumatoid arthritis (RA). It targets the Fc region of immunoglobulin G (IgG), forming immune complexes that contribute to inflammation and ti
Learn moreThe speckled pattern in ANA (Antinuclear Antibody) testing is one of the most common and diagnostically significant patterns, characterized by its distinctive, fine or coarse speckled appearance under a fluorescence microscope. This pattern indicates
Learn more