ANA 12 Plus Profile (RDL)
Serum
Performed by: LabCorp
ANA 12 Plus Profile is reflexive and consists of the following:
Anti-Nuclear Ab (ANA)
If positive, reflexes to following 14 components:
- Anti-Cardiolipin Ab (IgG, IgA and IgM Isotypes)
- Anti-Centromere Ab
- Anti-Chromatin Ab
- Anti-dsDNA Ab by Farr
- Anti-La (SS-B) Ab
- Anti-Ro (SS-A) Ab
- Anti-Scl-70 Ab
- Anti-Sm
- Anti-TPO (Thyroid Microsomal Peroxidase) Ab
- Anti-U1 RNP
- C3 Complement
- C4 Complement
- Rheumatoid Factor by Turb
- Anti-CCP (Cyclic Citrullinated Peptide) Ab.
If ANA is positive, all tests listed are performed. If ANA is negative, an Anti-Ro (SS-A) Ab test is performed to catch the small percentage of ANA false negative results. ANA includes titer and pattern.
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Biomarkers included in this panel:
Anti-Cardiolipin antibodies (aCL) of the IgA class are autoantibodies that target cardiolipin, a phospholipid found in cell membranes. While less commonly discussed than their IgG and IgM counterparts, IgA anti-cardiolipin antibodies also play a role
Learn moreAnti-Cardiolipin antibodies (aCL) of the IgG class are a type of autoantibody directed against cardiolipin, a phospholipid present in cell membranes. These antibodies are significant in the diagnosis and management of autoimmune disorders, particular
Learn moreAnti-Cardiolipin antibodies (aCL) of the IgM class are autoantibodies directed against cardiolipin, a specific phospholipid in cell membranes. These antibodies are clinically significant, especially in the context of antiphospholipid syndrome (APS),
Learn moreAnti-CCP antibodies, or anti-cyclic citrullinated peptide antibodies, are autoantibodies frequently found in the blood of individuals with rheumatoid arthritis (RA). These antibodies target proteins that have been altered by a process called citrulli
Learn moreThe anti-double stranded DNA (anti-dsDNA) tests are used to help diagnose and monitor lupus, also called systemic lupus erythematosus or SLE, a chronic inflammatory autoimmune disorder in which the immune system mistakenly targets the body’s ow
Learn moreAnti-La (SS-B) Ab (RDL)
The Anti-La (SS-B) Antibody test is an important diagnostic tool for autoimmune disorders. This test specifically detects antibodies against the La (or SS-B) antigen, which is another key protein target in certain autoimmune diseases. The presence of
Learn moreAnti-Nuclear Antibody by IFA (RDL) refers to a diagnostic test that detects antinuclear antibodies (ANAs) in the blood. ANAs are a group of autoantibodies that target substances found in the nucleus of cells, and their presence is often associated wi
Learn moreAnti-Ro (SS-A) Ab (RDL)
The Anti-Ro (SS-A) Antibody test is a critical diagnostic tool in the assessment of autoimmune diseases. This test detects antibodies against the Ro/SS-A antigen, a protein implicated in the development of certain autoimmune conditions. The presence
Learn moreAnti-Scl-70 Ab (RDL)
Anti-Scl-70 antibodies, also known as Anti-Topoisomerase I antibodies, are a specific type of autoantibody primarily associated with systemic sclerosis (scleroderma), a chronic autoimmune disease. These antibodies target the enzyme topoisomerase I, w
Learn moreAnti-Sm Ab (RDL)
Anti-Sm antibodies (Anti-Smith antibodies) are autoantibodies that are strongly associated with systemic lupus erythematosus (SLE), a chronic autoimmune disease. The presence of Anti-Sm antibodies is considered a specific marker for SLE, as these ant
Learn moreAnti-TPO Ab (RDL)
Anti-TPO antibodies (Anti-Thyroid Peroxidase antibodies) are autoantibodies directed against thyroid peroxidase, an enzyme crucial for the production of thyroid hormones. These antibodies are a key marker in autoimmune thyroid diseases, particularly
Learn moreAnti-U1 RNP Ab (RDL)
The Anti-U1 RNP (Ribonucleoprotein) Antibody test is a specific diagnostic tool used in the evaluation of connective tissue diseases. This test detects antibodies against the U1 RNP, a component of a small nuclear ribonucleoprotein complex involved i
Learn moreC3 Complement (RDL)
C3 Complement, often simply referred to as C3, is a crucial protein component of the immune system's complement system. The complement system is a part of the innate immune response and plays a significant role in inflammation and defending again
Learn moreC4 Complement (RDL)
C4 Complement, an essential component of the immune system's complement pathway, plays a pivotal role in both innate and adaptive immunity. Similar to C3, C4 is involved in the activation of the complement system, particularly in the classical an
Learn more