Organic Acids, Plasma
Organic Acids, Urine assay, is the preferred test when screening for inherited disorders of metabolism. This plasma test is not as sensitive and will only detect the organic acids listed.
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Biomarkers included in this panel:
2-Hydroxy-3-methylpentanoic acid or 2-hydroxy-3-methylvaleric acid (HMVA) is an organic acid generated by L-isoleucine metabolism. It is derived from the reduction of 2-Keto-3-methylvaleric acid (KMVA), possibly through the action of a lactate dehydr
Learn more2-Ketoisocaproic Acid is a B-Complex Vitamin Marker (Leucine catabolism). 2-Ketoisocaproic Acid is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids.
Learn moreAKA: alpha-Ketoisovaleric acid Alpha-Ketoisovaleric acid is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids.
Learn more3-Oh-Butyric Acid is a metabolic marker of blood sugar utilization and insulin function.
Learn moreAcetoacetic acid (=acetoacetate) is a ketone body and a weak Beta-keto acid produced from acetyl-CoA in the mitochondrial matrix of hepatocytes.
Learn moreCitric acid, cis-aconitic acid, and isocitric acid are the first three metabolites in the Krebs Citric Acid energy production cycle, which operates in the mitochondria of your cells.
Learn moreFormed from pyruvate in anaerobic or oxygen-starved (hypoxic) conditions to allow for ongoing production of ATP.
Learn morePyruvic Acid feeds into the citric acid cycle & converts into acetyl CoA. Pyruvate is formed from carbohydrate via glucose or glycogen & secondarily from fats (glycerol) & glycogenic amino acids. Pyruvic acid is also formed from lactic ac
Learn moreSuccinate (or succinic acid) is an important metabolite that is involved in several chemical processes in the body.
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