Complete Hormones FMV - Menopause Female (Genova Diagnostics)

Complete Hormones is Genova's most comprehensive urinary hormone profile, and is designed to assist with the clinical management of hormone-related symptoms in both male and females. This profile assesses parent hormones and their metabolites as well as key metabolic pathways, provides insight into the contribution that sex hormones may have in patients presenting with hormone-related complaints, and helps assess disease risk associated with elevated estrogen metabolites.

Urine measures the most metabolites, providing more insight into associated disease risk.

The Complete Hormones profile evaluates:

- Progesterone (via pregnanediol)

- Glucocorticoids, including cortisol

- Androgens, including DHEA and testosterone, and their metabolites

- Estrogens (E1 Estrone, E2 Estradiol, E3 Estriol) and metabolites, including hydroxylated and methoxylated estrogens

- Methylation capacity

- 5α-reductase activity

- Anabolic/Catabolic Balance

When should the Complete Hormones test be considered?

The Complete Hormones test is designed to assist in the management of hormone-related symptoms in both males and females.

The Complete Hormones test is ideal for establishing a baseline assessment of parent hormones and their metabolites ahead of clinical intervention with hormone therapy (HT) as well as subsequent monitoring if needed in both female and male patients.

The Complete Hormones test provides insight into the impact that shifting hormone levels may play in men (andropause or male menopause) and women (peri/menopause). Symptoms include the following:

  • Weight gain
  • Anxiety
  • Fatigue
  • Muscle mass loss
  • Muscle weakness
  • Low libido and sexual performance issues
  • Hair loss
  • Sleep disturbances
  • Brain fog
  • Mood instability
  • Hot flashes
  • Vaginal dryness

11-Hydroxy-androsterone (FMV urine, menopause)

Optimal range: 43 - 391 nmol/dL (SG)

11-Hydroxy-androsterone is a 5β-reduced compound that is an end product of androgen catabolism.

In the Genova complete hormone test this marker is part of the "Total 17-ketosteroids" group.

Androgens are important hormones in the health of both men and women. Testosterone and DHEA are metabolized into what is collectively known as the 17-ketosteroids (DHEA is formally included as a 17-ketosteroid). Together, these markers provide a comprehensive assessment of androgen sufficiency, as well as evaluating the need for, and monitoring of, androgen hormone therapy.

LEARN MORE

11-Hydroxy-etiocholanolone (FMV urine, menopause)

Optimal range: 49 - 336 nmol/dL (SG)

11-Hydroxy-etiocholanolone is a compound that is an end product of androgen catabolism.

In the Genova complete hormone test this marker is part of the "Total 17-ketosteroids" group.

Androgens are important hormones in the health of both men and women. Testosterone and DHEA are metabolized into what is collectively known as the 17-ketosteroids (DHEA is formally included as a 17-ketosteroid). Together, these markers provide a comprehensive assessment of androgen sufficiency, as well as evaluating the need for, and monitoring of, androgen hormone therapy.

LEARN MORE

11-Keto-androsterone (FMV urine, menopause)

Optimal range: 46 - 258 nmol/dL (SG)

11-Keto-androsterone is a that is an end product of androgen catabolism.

In the Genova complete hormone test this marker is part of the "Total 17-ketosteroids" group.

Androgens are important hormones in the health of both men and women. Testosterone and DHEA are metabolized into what is collectively known as the 17-ketosteroids (DHEA is formally included as a 17-ketosteroid). Together, these markers provide a comprehensive assessment of androgen sufficiency, as well as evaluating the need for, and monitoring of, androgen hormone therapy.

LEARN MORE

11-Keto-etiocholanolone (FMV urine, menopause)

Optimal range: 0 - 0 nmol/dL (SG)

11-Keto-etiocholanolone is a 5β-reduced compound that is an end product of androgen catabolism.

In the Genova complete hormone test this marker is part of the "Total 17-ketosteroids" group.

Androgens are important hormones in the health of both men and women. Testosterone and DHEA are metabolized into what is collectively known as the 17-ketosteroids (DHEA is formally included as a 17-ketosteroid). Together, these markers provide a comprehensive assessment of androgen sufficiency, as well as evaluating the need for, and monitoring of, androgen hormone therapy.

LEARN MORE

16a-Hydroxyestrone (16a-OH E1) / Menopause

Optimal range: 0.4 - 7.7 mcg/g Creat.

16α-Hydroxyestrone (16α-OH-E1), or hydroxyestrone, also known as estra-1,3,5(10)-trien-3,16α-diol-17-one, is an endogenous steroidal estrogen and a major metabolite of estrone, as well as an intermediate in the biosynthesis of estriol. It is a potent estrogen similarly to estrone, and it has been suggested that the ratio of 16α-hydroxyestrone to 2-OH-E1, the latter being much less estrogenic in comparison and even antiestrogenic in the presence of more potent estrogens like estradiol, may be involved in the pathophysiology of breast cancer. Conversely, 16α-hydroxyestrone may help to protect against osteoporosis.

LEARN MORE

17 - Hydroxysteroids Total (FMV urine, menopause)

Optimal range: 973 - 8177 nmol/dL (SG)

An elevated 17-hydroxysteroids total and/or cortisol total may be caused by stress, strenuous exercise, inflammation, hypoglycemia, insulin resistance, hypothyroidism, or licorice ingestion.

LEARN MORE

17 - Ketosteroids Total (FMV urine, menopause)

Optimal range: 303 - 2184 nmol/dL (SG)

ANDROGENS such as DHEA, testosterone, and androstenedione tend to be extensively metabolized into downstream androgen compounds. As a result, the levels of testosterone along with “Total 17-ketosteroids” (DHEA plus metabolites) should be used to assess androgen status and/or efficacy of androgen replacement.

LEARN MORE

17-Hydroxysteroids, Total (menopause)

Optimal range: 973 - 8177 nmol/dL (SG)

An elevated 17-hydroxysteroids total and/or cortisol total may be caused by stress, strenuous exercise, inflammation, hypoglycemia, insulin resistance, hypothyroidism, or licorice ingestion.

LEARN MORE

17-Ketosteroids, Total (FMV urine, menopause)

Optimal range: 303 - 2184 nmol/dL (SG)

Testosterone and DHEA are metabolized into what are collectively known as the 17-ketosteroids.

LEARN MORE

2-OH(E1+E2) / 2-MeO(E1+E2) / Menopause

Optimal range: 0.4 - 11.6 Ratio

There is evidence that methoxylated estrogens, especially the 2-pathway methoxylated estrogens (E1 and E2), are associated with decreased breast cancer risk; 2-MeOE2, produced from 2-OHE2, has been described to have anti-proliferative, antingiogenic, and pro-apoptotic activity in multiple types of cancer.

LEARN MORE

Research focus is shifting toward 4-hydroxyesterone which is thought to have greater estrogenic and genotoxic potential than either 2-hydroxyestrone or 16a-hydroxyestrone.

LEARN MORE

Most recent studies find an increased breast cancer risk associated with the ratio of 4-pathway cetechols to 4-pathway methylated catechols.

LEARN MORE

allo-Tetrahydrocortisol, a-THF (FMV urine, menopause)

Optimal range: 38 - 331 nmol/dL (SG)

This marker is part of the "17-Hydroxysteroids" group. Please refer to the "17-Hydroxysteroids, Total" marker.

LEARN MORE

Anabolic/Catabolic Balance (FMV, menopause)

Optimal range: 0.1 - 1.4 Ratio

The Anabolic/Catabolic Balance refers to the balance between "growth and healing" (anabolic) and "wear and tear" (catabolic) activity in the body. Both anabolic and catabolic metabolism are essential to health.

LEARN MORE

Androstanediol (FMV urine, menopause)

Optimal range: 0 - 20 nmol/dL (SG)

The measurement of androstanediol, in addition to testosterone, is of interest for the evaluation of androgenic activity.

LEARN MORE

Androsterone (FMV urine, menopause)

Optimal range: 43 - 580 nmol/dL (SG)

Androsterone and Etiocholanolone are DHEA metabolites via Androstenedione and the 5α- and 5β-reductase pathways.

LEARN MORE

DHEA (FMV urine, menopause)

Optimal range: 2.8 - 33 nmol/dL (SG)

DHEA is a hormone produced by both the adrenal gland and the brain. DHEA leads to the production of androgens and estrogens. DHEA levels in the body begin to decrease after age 30. Levels decrease more quickly in women.

LEARN MORE

E/A: 5b/5a Ratio (FMV urine, menopause)

Optimal range: 0.55 - 2.45 Ratio

The Etiocholanolone/Androsterone (E/A) Ratio assesses androgen metabolism by comparing the enzymatic activity of 5β-reductase/5α-reductase.

LEARN MORE

Estradiol (FMV urine, menopause)

Optimal range: 0.6 - 15.4 mcg/g Creat.

The most physiologically active estrogen. Binds to both to ER and Estrogen Receptor Beta (ERβ). Estradiol, made in the ovary, rapidly converts to estrone. Poor symptom control with estrogen replacement may suggest the need for improving absorption or increasing estradiol.

LEARN MORE

Estriol (FMV urine, menopause)

Optimal range: 0.7 - 30.8 mcg/g Creat.

Has weak estrogen activity. Considered to be a protective estrogen. Most prevalent estrogen in pregnancy.

LEARN MORE

Estrone (FMV urine, menopause)

Optimal range: 1.1 - 26.2 mcg/g Creat.

Produced by the ovaries, the estrone hormone is one of three types of estrogen, and it is one of the major hormones found in the bodies of postmenopausal women. While research into estrone function is still ongoing, since it is the least powerful of the three estrogen types, women should still understand this hormone and its known effects on the body.

- Weaker compared to Estradiol (Research says the estrogenic activity is about 4% of estradiol’s activity)

- Most abundant in menopause

- Made via aromatization in several tissues like fat and muscle

- Converts into estradiol (E2)

Estrone (E1) is also made by the ovary but in fat tissue in lesser quantities. While not as abundant in circulation as estradiol, estrone excess can still increase the risk for estrogen dominant cancers and estrogen dominant symptoms such as breast tenderness, heavy menstrual cycles, headaches, and erectile dysfunction and breast development in men just like estradiol. Estrone is commonly thought to be more abundant during menopause. 

Estradiol and estrone can interconvert into each other. 

LEARN MORE

Etiocholanolone (FMV urine, menopause)

Optimal range: 82 - 765 nmol/dL (SG)

Etiocholanolone is an androstenedione and testosterone metabolite that is excreted in the urine. It is produced from androstenedione and the 5-alpha and 5-beta-reductase metabolic pathways. It is helpful in evaluating adrenal and androgen function.

LEARN MORE

Pregnanediol (FMV urine, menopause)

Optimal range: 8 - 196 nmol/dL (SG)

Progesterone rapidly metabolizes by the time it reaches the urine, and its direct metabolite, pregnanediol, is a reflection of circulating progesterone concentrations.

LEARN MORE

Pregnanetriol (FMV urine, menopause)

Optimal range: 23 - 176 nmol/dL (SG)

Progesterone is metabolized into numerous downstream compounds, but most immediately into pregnanediol and pregnanetriol. Urine levels of these metabolites tend to correlate with levels of serum progesterone, thus may be used to assess status of the hormone.

LEARN MORE

Testosterone (FMV urine, menopause)

Optimal range: 8 - 48 nmol/dL (SG)

Testosterone is the major androgen in the body. It is converted to dihydrotestosterone by 5-alphareductase, and to estradiol by aromatase.

LEARN MORE

Tetrahydrocortisol, THF (FMV urine, menopause)

Optimal range: 126 - 559 nmol/dL (SG)

This marker is part of the "17-Hydroxysteroids" group. Please refer to the "17-Hydroxysteroids, Total" marker.

LEARN MORE

Tetrahydrocortisone, THE (FMV urine, menopause)

Optimal range: 627 - 6568 nmol/dL (SG)

This marker is part of the "17-Hydroxysteroids" group. Please refer to the "17-Hydroxysteroids, Total" marker.

LEARN MORE

Tetrahydrodeoxycortisol (FMV urine, menopause)

Optimal range: 0 - 7.7 nmol/dL (SG)

This marker is part of the "17-Hydroxysteroids" group. Please refer to the "17-Hydroxysteroids, Total" marker.

LEARN MORE
;