Antinuclear Antibodies (ANA) Screen, Reflex ANA IFA dsDNA Antibodies

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Antinuclear Antibodies (ANA) are a group of autoantibodies that target substances found in the nucleus of a cell. The ANA screen is a preliminary test used to detect the presence of these antibodies in the blood, which may indicate the presence of an autoimmune disorder. When an ANA screen yields a positive or indeterminate result, a Reflex ANA IFA (Indirect Fluorescent Antibody) test may be performed for a more detailed analysis. This test can identify specific patterns of fluorescence that correlate with various types of autoimmune diseases.

Additionally, the detection of double-stranded DNA (dsDNA) antibodies, through a reflex test, is especially significant as these are highly specific for systemic lupus erythematosus (SLE), a chronic autoimmune disease. The presence of dsDNA antibodies can be indicative of the disease activity and severity.

Therefore, the combination of these tests aids clinicians in diagnosing, monitoring, and managing autoimmune conditions, although the results are always considered in the broader context of clinical symptoms and other diagnostic findings.

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