Intestinal Antigenic Permeability Screen (Cyrex Laboratories)

This test measures intestinal permeability to large molecules, which inflame the immune system.

Gluten can cause silent inflammation in the gut, which can eventually lead to intestinal permeability, or “leaky gut.”

Also, NSAID medications, chronic stress, excess alcohol, proton pump inhibitors and other factors can also contribute to “leaky gut” which allows undigested food particles, bacteria, and other antigens to escape into the bloodstream where they can trigger allergies, sensitivities, and inflammation in various parts of the body. This test helps to determine if leaky gut is present and can be used to monitor complete healing of the gut lining.

For an interpretative chart, please visit our blog entry called "Guide to Intestinal antigenic permeability screen (Cyrex Screen 2)".

Actomyosin IgA

Optimal range: 0 - 20.1 ELISA Index

Actomyosin is a smooth muscle protein found throughout the body. In the intestinal barrier's epithelial cells, actomyosin proteins form cables called the Actin Network.

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Lipopolysaccharides (LPS) IgA

Optimal range: 0 - 1.8 ELISA Index

Lipopolysaccharides (LPS) are endotoxins from gram-negative bacteria in the gut. The LPS protects gram-negative bacteria from gram-positive bacteria. When gram-negative bacterium dies it releases its LPS, which travels through the epithelial cells of the intestinal barrier and finds its way into the blood stream.

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Lipopolysaccharides (LPS) IgG

Optimal range: 0 - 2.6 ELISA Index

Lipopolysaccharides (LPS) are endotoxins from gram-negative bacteria in the gut. The LPS protects gram-negative bacteria from gram-positive bacteria. When gram-negative bacterium dies it releases its LPS, which travels through the epithelial cells of the intestinal barrier and finds its way into the blood stream.

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Lipopolysaccharides (LPS) IgM

Optimal range: 0 - 2.1 ELISA Index

Lipopolysaccharides (LPS) are endotoxins from gram-negative bacteria in the gut. The LPS protects gram-negative bacteria from gram-positive bacteria. When gram-negative bacterium dies it releases its LPS, which travels through the epithelial cells of the intestinal barrier and finds its way into the blood stream.

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Occludin/Zonulin IgA

Optimal range: 0.1 - 1.6 ELISA Index

Occludin and Zonulin are proteins of the tight junctions found between epithelial cells of the intestinal barrier. These proteins are gate keepers of the body, allowing only small amino acid nutrients to pass into the blood stream.

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Occludin/Zonulin IgG

Optimal range: 0.3 - 1.6 ELISA Index

Occludin and Zonulin are proteins of the tight junctions found between epithelial cells of the intestinal barrier. These proteins are gate keepers of the body, allowing only small amino acid nutrients to pass into the blood stream.

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Occludin/Zonulin IgM

Optimal range: 0 - 1.8 ELISA Index

Occludin and Zonulin are proteins of the tight junctions found between epithelial cells of the intestinal barrier. These proteins are gate keepers of the body, allowing only small amino acid nutrients to pass into the blood stream.

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