DUTCH

The DUTCH test is a urine steroid hormone test that measures hormones and hormone metabolites from a dried urine sample.

16-OH-E1

Optimal range: 0.7 - 2.6 ng/mg

16α-Hydroxyestrone (16α-OH-E1), or hydroxyestrone, also known as estra-1,3,5(10)-trien-3,16α-diol-17-one, is an endogenous steroidal estrogen and a major metabolite of estrone, as well as an intermediate in the biosynthesis of estriol. It is a potent estrogen similarly to estrone, and it has been suggested that the ratio of 16α-hydroxyestrone to 2-OH-E1, the latter being much less estrogenic in comparison and even antiestrogenic in the presence of more potent estrogens like estradiol, may be involved in the pathophysiology of breast cancer. Conversely, 16α-hydroxyestrone may help to protect against osteoporosis.

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2-Methoxy-E1

Optimal range: 2.5 - 6.5 ng/mg

2-Methoxy-E2

Optimal range: 0.3 - 0.7 ng/mg

2-OH-E1

Optimal range: 5.1 - 13.1 ng/mg

2-OH-E2

Optimal range: 0 - 1.2 ng/mg

24hr Free Cortisol

Optimal range: 80 - 230 ug

24hr Free Cortisone

Optimal range: 220 - 450 ug

4-OH-E1

Optimal range: 0 - 1.8 ng/mg

A very carcinogenic estrogen metabolite, levels low in the reference range are desirable. Additional magnesium, liver support, and methylation support may help decrease 4-OH-E1 levels.

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4-OH-E2

Optimal range: 0.15 - 0.5 ng/mg

5-Hydroxyindoleacetate (5HIAA)

Optimal range: 2.5 - 7.5 ug/mg

5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors.

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5a-Androstanediol

Optimal range: 12 - 30 ng/mg

5a-DHT

Optimal range: 0 - 6.6 ng/mg

5b-Androstanediol

Optimal range: 20 - 75 ng/mg

8-OHdG (Waking)

Optimal range: 0 - 5.2 ng/mg

a-Pregnanediol

Optimal range: 200 - 740 ng/mg

This test measures pregnanediol, a metabolite of progesterone. It is used in the evaluation and decision making in women who are having difficulty becoming pregnant or maintaining a pregnancy. It is also used to monitor “high-risk” pregnancies.

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a-Tetrahydrocortisol (a-THF)

Optimal range: 75 - 370 ng/mg

Androsterone

Optimal range: 200 - 1650 ng/mg

b-Pregnanediol

Optimal range: 600 - 2000 ng/mg

Pregnanediol is a metabolite of the molecule of progesterone, which is important for fertility and for menstruation. Pregnanediol levels increase after ovulation and when the placenta releases the hormone.

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b-Tetrahydrocortisol (b-THF)

Optimal range: 1050 - 2500 ng/mg

b-Tetrahydrocortisone (b-THE)

Optimal range: 1550 - 3800 ng/mg

Cortisol A (Waking)

Optimal range: 12 - 55 ng/mg

Cortisol B (Morning)

Optimal range: 38 - 155 ng/mg

Cortisol C (Afternoon)

Optimal range: 7.3 - 30 ng/mg

Cortisol D (Night)

Optimal range: 0 - 14 ng/mg

Cortisone A (Waking)

Optimal range: 40 - 120 ng/mg

Cortisone B (Morning)

Optimal range: 90 - 230 ng/mg

Cortisone C (Afternoon)

Optimal range: 32 - 95 ng/mg

Cortisone D (Night)

Optimal range: 0 - 55 ng/mg

Creatinine A (Waking)

Optimal range: 0.2 - 2 mg/ml

Creatinine B (Morning)

Optimal range: 0.2 - 2 mg/ml

Creatinine C (Afternoon)

Optimal range: 0.2 - 2 mg/ml

Creatinine D (Night)

Optimal range: 0.2 - 2 mg/ml

DHEA-S (Urine)

Optimal range: 20 - 750 ng/mg

Epi-Testosterone

Optimal range: 2.3 - 14 ng/mg

Epi-Testosterone is one of several naturally-occurring testosterone compounds in the body that act as steroids. Athletes using anabolic steroids may be questioned about anabolic steroid use if testosterone increases while Epi-Testosterone levels stay low.

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Estradiol(E2)

Optimal range: 1.8 - 4.5 ng/mg

Estriol(E3)

Optimal range: 5 - 18 ng/mg

Estrone(E1)

Optimal range: 12 - 26 ng/mg

Etiocholanolone

Optimal range: 200 - 1000 ng/mg

Etiocholanolone is an androstenedione and testosterone metabolite that is excreted in the urine. It is produced from androstenedione and the 5-alpha and 5-beta-reductase metabolic pathways. It is helpful in evaluating adrenal and androgen function.

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Homovanillate (HVA)

Optimal range: 4 - 13 ug/mg

Melatonin (Waking)

Optimal range: 10 - 85 ng/mg

Metabolized Cortisol (THF+THE)

Optimal range: 2750 - 6500 ng/mg

Methylmalonate (MMA)

Optimal range: 0 - 2.2 ug/mg

Progesterone (Urine)

Optimal range: 6 - 20 ng/mL

Although progesterone is found in both males and females, it is primarily known for its role in conception, pregnancy, and the regulation of a woman’s menstrual cycle.

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Pyroglutamate

Optimal range: 32 - 60 ug/mg

Testosterone (DUTCH)

Optimal range: 2.3 - 14 ng/mg

Total DHEA Production

Optimal range: 400 - 3000 ng/mg

DHEA is often called the anti-aging hormone. It’s made in the adrenal glands naturally and levels hit their peak in your 20s. They start to dwindle after you hit 30. Estrogen and testosterone are created from DHEA.

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Total Estrogen

Optimal range: 27 - 62 ng/mg

Total estrogen is a reliable test for estrogen status and is used to detect hormone imbalances.

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Vanilmandelate (VMA)

Optimal range: 2.4 - 6.4 ug/mg

Xanthurenate

Optimal range: 0 - 1.4 ug/mg