Array 22 - Irritable Bowel/SIBO Screen

-- Identify the overgrowth of large intestinal bacteria in the small intestine and the release of bacterial cytotoxins

-- Evaluate a breach of intestinal barrier by bacterial cytotoxins and their entry into circulation

-- Assist in setting guidelines for treatment of irritable bowels/SIBO and reduce risk of igniting the autoimmune process

Recommended for Patients Who:

-- Have irritable bowels

-- Exhibit symptoms of malabsorption, including weight loss, anemia or fatty stools

-- Have associated conditions such as fatigue, reflux, skin disorders, obesity or food intolerances

Bacterial Cytotoxins IgM

Optimal range: 0 - 2.3 ELISA Index

Bacterial Cytotoxins refer to the cytolethal distending toxin, subunit B (CdtB) that is released by Escherichia coli, Salmonella, Shigella and Campylobacter jejuni. Utilizing subunits A and C, gram-negative bacteria can bind to human cells, allowing CdtB to infiltrate the cell. Inside the cell, CdtB contributes to cytoskeletal damage, which may induce apoptosis (cell death). CdtB is the first bacterial toxin known to act in the nucleus of a target cell.

Associated With:

- Irritable bowels


- Gut dysbiosis

- Chronic functional bowel changes

- Localized aggressive periodontitis


Cytoskeletal Proteins IgM

Optimal range: 0.2 - 2.3 ELISA Index

Cytoskeletal Proteins is the collective name given to intercellular adherent junctions that are involved in the integrity and functionality of the epithelial barrier. The major cytoskeletal proteins assessed in Array 22 are a-actinin, talin and vinculin. Alpha-actinin forms a lattice-like structure and stabilizes the muscle contractile, additionally a-actinin associates with signaling molecules. Talin is found in focal adhesions where it links the transmembrane receptors, integrins, to the actomyosin network and either directly or indirectly interacts with a-actinin and vinculin. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions.

Known Cross-Reactions: Alpha-actinin with anti-ssDNA