Immune System

Immunofixation Result, Serum

Optimal Result: 0 - 0 %.

The Immunofixation test is often used to diagnose multiple myeloma or Waldenstrom’s macroglobulinemia, when symptoms of the disorders are present. Both conditions produce abnormal Ig.

Clinical symptoms of multiple myeloma include:

- bone pain in the back or ribs
- weakness and fatigue
- weight loss
- broken bones
- recurrent infections
- weakness in the legs
- nausea and vomiting

Clinical symptoms of Waldenstrom’s macroglobulinemia include:

- weakness
- severe fatigue
- bleeding from the nose or gums
- weight loss
- bruises or other skin lesions
- blurred vision
- swelling of the lymph nodes, spleen, or liver

This test alone cannot be used to make a diagnosis. The test only indicates whether abnormal Ig is present.

Another test must be used to measure the amount of abnormal Ig in the blood. This test is called serum protein electrophoresis (SPEP) test. Your doctor can use it to confirm certain diagnoses.

Immunofixation can either reveal a normal pattern or identify a monoclonal protein or a polyclonal immunoglobulin pattern.

A normal result includes:

- a darker immunoglobulin G (IgG) lane,

- a lighter immunoglobulin A (IgA),

- an absent immunoglobulin M (IgM),

- and a denser kappa compared to lambda lane, with ratio of 2:1.

In a normal result, the lanes are broad and there is a gradual and smooth reduction in the color density toward the edges of the lane with no narrow dense band with sharp borders identified within the lane.

In some cases, all the lanes are homogeneously darkened to the same degree. This pattern represents the presence of polyclonal immunoglobulin. Again, the lanes are broad and the transition to the lane borders is smooth. In this case, the IgM lane, which is normally absent, is broad with smooth borders.

When a narrow band with sharp borders can be identified, it implies the presence of a monoclonal protein.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Understand blood, stool, and urine medical results from your labs.

Get 10% off your plan.

Use promocode

Advanced Plan personal plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium personal plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Pro Plan for health professionals


  • Track multiple clients results
  • No setup fees
  • No hidden costs
  • Cancel anytime
  • Instant interpretations
  • Use the free template forms
  • 2500+ biomarkers explained
  • Additional team member $25
  • Personal training and support

Healthmatters.io software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals
×

Understand Your Lab Result Now

  • Instant interpretation
  • 2500+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode:

;