Immunofixation Result, Serum

Serum

Other names: IFE INTERPRETATION

Reference range:

Immune System

From Healthmatters.io Team

Lab Results Explained and Tracked

The Immunofixation test is often used to diagnose multiple myeloma or Waldenstrom’s macroglobulinemia, when symptoms of the disorders are present. Both conditions produce abnormal Ig.

Clinical symptoms of multiple myeloma include:

- bone pain in the back or ribs
- weakness and fatigue
- weight loss
- broken bones
- recurrent infections
- weakness in the legs
- nausea and vomiting

Clinical symptoms of Waldenstrom’s macroglobulinemia include:

- weakness
- severe fatigue
- bleeding from the nose or gums
- weight loss
- bruises or other skin lesions
- blurred vision
- swelling of the lymph nodes, spleen, or liver

This test alone cannot be used to make a diagnosis. The test only indicates whether abnormal Ig is present.

Another test must be used to measure the amount of abnormal Ig in the blood. This test is called serum protein electrophoresis (SPEP) test. Your doctor can use it to confirm certain diagnoses.

Immunofixation can either reveal a normal pattern or identify a monoclonal protein or a polyclonal immunoglobulin pattern.

A normal result includes:

- a darker immunoglobulin G (IgG) lane,

- a lighter immunoglobulin A (IgA),

- an absent immunoglobulin M (IgM),

- and a denser kappa compared to lambda lane, with ratio of 2:1.

In a normal result, the lanes are broad and there is a gradual and smooth reduction in the color density toward the edges of the lane with no narrow dense band with sharp borders identified within the lane.

In some cases, all the lanes are homogeneously darkened to the same degree. This pattern represents the presence of polyclonal immunoglobulin. Again, the lanes are broad and the transition to the lane borders is smooth. In this case, the IgM lane, which is normally absent, is broad with smooth borders.

When a narrow band with sharp borders can be identified, it implies the presence of a monoclonal protein.

Lab Results Explained and Tracked

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Immunofixation Result, Serum

All Your Lab Results. One Simple Dashboard.

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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All Your Lab Results.
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