Organic Acids Metabolomic Mapping (NutriPATH)

The Organic Acids Metabolomic Profile is a nutritional test providing insights into organic acids and a view into the body’s cellular metabolic processes. Additionally, children’s reference ranges are designed to provide more accurate paediatric nutritional evaluations. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximise patient responses and lead to improved patient outcomes.

The Organic Acids Metabolomic profile provides vital patient information from a single urine specimen. This organic acids nutritional test is valuable for determining:

- Functional vitamin and mineral status

- Amino acid insufficiencies like carnitine and NAC

- Oxidative damage and antioxidant need

- Phase I & Phase II detoxification capacity

- Functional B-complex vitamin need

- Neurotransmitter metabolites

- Mitochondrial energy production

- Methylation sufficiency

- Lipoic acid and CoQ10 status

- Markers for bacterial and yeast overgrowth

- Oxalate markers

- Nutritional markers

Ascorbic Acid (Vit C)

Optimal range: 10 - 200 mmol/molCr

Ascorbic Acid is a natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries.

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Cortisol (OA)

Optimal range: 166 - 507 nmol/L

Cortisol is a stress hormone produced by the adrenal glands and is the primary agent used in our body’s flight or fight response to threatening stimuli.

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Creatinine, Urine Spot

Optimal range: 5 - 13 mmol/L

Creatinine values are measured to correct results for urine dilution.

Creatinine is a waste product produced by muscles from the breakdown of a compound called creatine. Creatinine is filtered from the blood by the kidneys and released into the urine.

The amount of creatinine produced in the body is dependent on muscle mass and is relatively constant for an individual. The amount of creatinine removed from the blood depends on both the filtering ability of the kidneys and the rate at which blood is carried to the kidneys.

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Isocitric Acid

Optimal range: 35 - 143 ug/mgCR

Citric acid, cis-aconitic acid, and isocitric acid are the first three metabolites in the Krebs Citric Acid energy production cycle, which operates in the mitochondria of your cells. 

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Kynurenic Acid

Optimal range: 0 - 1.5 ug/mgCR

Kynurenic Acid is product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Your body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein.

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ParaHydroxyphenyllactate

Optimal range: 0 - 0.66 ug/mgCR

p-hydroxyphenyllactate is a marker of cell turnover. It is also a metabolite in tyrosine degradation and may be useful for studying disorders of tyrosine metabolism.

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Picolinic Acid

Optimal range: 2.8 - 13.5 ug/mgCR

Picolinate is a neurotransmitter metabolism marker and is produced under inflammatory conditions.

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Tartaric Acid

Optimal range: 0 - 7 ug/mgCR

Breakdown product of hyaluronic acid; also found in some foods.

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