Interleukin 2 (IL-2) is a pleiotropic (=having multiple effects from a single gene) cytokine produced primarily by mitogen- or antigen- activated T lymphocytes.
Interleukin 2 plays a role in promoting the clonal expansion of antigen-specific cytotoxic and suppressor T cells. In vitro studies suggest that Interleukin 2 may also be produced by dendritic cells and certain lymphoma cell lines. In addition, IInterleukin 2 has been shown to mediate multiple immune responses on a variety of cell types. Interleukin 2 stimulates the proliferation of thymocytes; stimulates the proliferation and differentiation of activated B cells; promotes the growth, differentiation, and cytocidal activity of monocytes; induces the growth of natural killer cells and stimulates cytokine production by these cells, as well as enhancing the cytolytic activity of these cells; enhances the production of lymphocyte-activated killer (LAK) cells; and induces the proliferation and differentiation of oligodendrocytes.
References:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728644/
Serum concentrations of Interleukin 2 are elevated in people with liver diseases and cirrhosis.
Renal failure is an important confounding factor for Interleukin 2 levels in liver disease patients. Interleukin 2 levels are associated with cytokine and chemokine concentrations as well as circulating inflammatory cells, especially from the monocyte lineage. These data indicate that Interleukin 2 might be a potential marker for immune cell activation in CLD, especially for proinflammatory and profibrogenic non-classical CD14+CD16+ monocytes.
References:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434055/
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14.3.3 ETA PROTEIN, Acetylcholine Receptor (AChR) Antibody, Activated partial thromboplastin time (APTT), Anti-Smith Antibody, Anticardiolipin Ab,IgG,Qn, Antinuclear Antibodies Direct (ANA Direct), CARDIOLIPIN AB (IGA), CARDIOLIPIN AB (IGG), CARDIOLIPIN AB (IGM), CCP Antibodies IgG/IgA, Complement C3, Complement C3a, Complement C4, Serum, Complement C4a, Complement, Total (CH50), Cyclic Citrullinated Peptide Antibody, Dilute Russell's viper venom time (dRVVT), ds-DNA Antibody, IgG, Erythrocyte Sedimentation Rate (ESR), Histamine, Plasma, HLA-B27 (Human Leukocyte Antigen B27), Immature Grans (Abs), Immature Granulocytes (%), Immunofixation Result, Serum, Immunoglobulin A, Qn, Serum, Immunoglobulin D, Quant, Serum, Immunoglobulin E, Total, Immunoglobulin G, Qn, Serum, Immunoglobulin M, Qn, Serum, Interleukin-2, Serum, Interleukin-6, Jo 1 Antibodies, IgG, Serum, Liver-Kidney Microsomal Antibodies, Lupus Anticoagulant, PHOSPHATIDYLETHANOLAMINE AB (IGA), PHOSPHATIDYLETHANOLAMINE AB (IGG), PHOSPHATIDYLETHANOLAMINE AB (IGM), PHOSPHATIDYLSERINE AB (IGA), PHOSPHATIDYLSERINE AB (IGG), PHOSPHATIDYLSERINE AB (IGM), Prothrombin Time (PT), Prothrombin Time (PT) INR, RA Latex Turbid, Reptilase Clotting Time, Rheumatoid factor, TGF-b1, Thrombin time, Transforming Growth Factor beta, Plasma, Tryptase, VEGF, Plasma
