Histamine, Plasma

Plasma
check icon Optimal Result: 0 - 0.99 ng/mL.

Histamine is a substance that is produced by the body as part of an allergic reaction. Histamine tests are sometimes ordered when a person has symptoms that suggest anaphylaxis, especially when the diagnosis is not clear and/or the symptoms are recurrent. Symptoms of anaphylaxis include:

  • Difficulty breathing, wheezing
  • Flushing
  • Itching, often with visible hives
  • Light-headedness or dizziness
  • Low blood pressure
  • Swelling of the throat, face, tongue, and/or eyes

Many of these symptoms are also seen with other conditions.

What does it mean if your Histamine, Plasma result is too high?

Elevated histamine levels in the body, a condition known as histaminosis or histamine intolerance, can lead to a variety of symptoms and indicate several underlying health issues. Histamine is a chemical that plays a role in several of the body's physiological functions, including immune responses, digestion, and regulating sleep-wake cycles. Here's what elevated histamine levels can mean:

→ Allergic Reactions: One of the most common causes of elevated histamine is an allergic reaction, where the body's immune system overreacts to a foreign substance (allergen). Common allergens include pollen, pet dander, certain foods, and insect stings.

→ Histamine Intolerance: This occurs when there's an imbalance between accumulated histamine and the capacity to break it down. In cases of histamine intolerance, consuming foods high in histamine can lead to symptoms because the body cannot degrade the histamine efficiently.

→ Mast Cell Activation Disorders: Conditions like Mast Cell Activation Syndrome (MCAS) involve abnormal accumulation and release of histamine from mast cells, a type of immune cell.

→ Gastrointestinal Disorders: Certain gastrointestinal issues, such as inflammatory bowel disease (IBD), can be associated with increased histamine levels.

→ Certain Foods: Eating foods high in histamine, such as aged cheeses, fermented products, alcohol, and processed meats, can raise histamine levels in the body.

→ Medications: Some medications can either increase histamine release or interfere with its breakdown.

→ Symptoms of High Histamine: These can include headaches, nasal congestion, fatigue, hives, digestive issues, irregular menstrual cycles, nausea, and in severe cases, anaphylaxis, a potentially life-threatening reaction.

→ Diagnosis and Treatment: Diagnosis usually involves a detailed medical history, symptom diary, and sometimes blood tests. Treatment typically focuses on managing symptoms, identifying and avoiding triggers, and possibly using medications like antihistamines to reduce histamine levels.

It's important to consult with a healthcare provider if you suspect you have issues related to histamine, as the symptoms can be similar to other medical conditions. Proper diagnosis and treatment are essential for managing symptoms and improving quality of life.

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