Histamine is a substance that is produced by the body as part of an allergic reaction. Histamine tests are sometimes ordered when a person has symptoms that suggest anaphylaxis, especially when the diagnosis is not clear and/or the symptoms are recurrent. Symptoms of anaphylaxis include:
Many of these symptoms are also seen with other conditions.
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Histamine levels can be increased in people with mastocytosis, a disorder which affects various organs and may cause symptoms to an allergic reaction. Other factors such as eating histamine rich foods and being deficient in minerals such as magnesium can also contribute to elevated histamine levels.
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