What is Anti-Fodrin Ab, IgA (RDL)?
Anti-Fodrin Antibody, IgA is a blood test that detects IgA-class autoantibodies targeting fodrin, a protein found inside the cells of the salivary and tear glands. These autoantibodies are part of an immune response that mistakenly attacks the body's own moisture-producing tissues—especially in Sjögren’s syndrome.
Unlike IgG antibodies, which are more systemic, IgA antibodies are often involved in mucosal and glandular immune responses. Measuring Anti-Fodrin IgA can provide valuable insight into localized glandular autoimmunity—particularly in the early or seronegative stages of disease.
Why is this test important?
This test is most commonly ordered to help diagnose:
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Sjögren’s syndrome, especially in patients with chronic dry mouth, dry eyes, or salivary gland swelling
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Seronegative cases, where common markers like Anti-SSA (Ro) and Anti-SSB (La) are negative
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Early autoimmune gland involvement before full-blown disease develops
What does a positive Anti-Fodrin IgA result mean?
A positive Anti-Fodrin Ab, IgA result may indicate:
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Immune system activity against salivary or lacrimal glands, supporting a diagnosis of Sjögren’s syndrome
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Possible early-stage or localized autoimmune disease involving mucosal tissues
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Glandular involvement in other autoimmune conditions, such as lupus or autoimmune thyroid disease
This marker is not exclusive to Sjögren’s but is considered helpful when used in combination with symptoms and other test results.
What does a negative result mean?
A negative Anti-Fodrin IgA result suggests that your immune system is not currently producing detectable IgA antibodies against fodrin. However, this does not rule out Sjögren’s or other autoimmune diseases—other markers or gland biopsies may still be needed, especially if symptoms persist.
What happens next if elevated?
If your Anti-Fodrin Ab, IgA level is elevated:
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Your provider may evaluate other markers (e.g., Anti-SSA, ANA, ESR/CRP) and clinical symptoms
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You might be referred to a rheumatologist for further diagnosis and care
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Management may involve symptom control (e.g., artificial tears, saliva stimulants), anti-inflammatory treatment, and monitoring for systemic involvement
Bottom Line
Anti-Fodrin Ab, IgA (RDL) is a useful autoimmune marker for identifying immune system activity targeting glandular tissues, particularly in suspected Sjögren’s syndrome. It may be especially helpful in early-stage or seronegative cases, providing another diagnostic tool when traditional markers are absent. If you’re experiencing symptoms like dry mouth, dry eyes, or salivary gland swelling, this test can offer important insight.
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