OMX Organic Metabolomics / Diagnostic Solutions

Advanced Organic Acids and Amino Acids Profile

Metabolomics, also called comprehensive metabolic profiling, evaluates patterns of metabolites related to core biological systems, offering insight into biochemical dysfunctions that may be of concern.

Organic acids and other small molecules are intermediate compounds that can define the efficient flow of pathways and substrates such as amino acids to reveal the level of inputs, which together establish the functional status of key areas of health.

Metabolites are impacted by many factors and can change in response to diet, nutrient status, toxin exposures, exercise, physiologic demands, genetics, gut microbiome alterations, or disease stage.

Metabolic analysis can help to evaluate the function of key pathways to better target support.

OMX Provides Insight Into the Following Areas of Health:

- Metabolic and macronutrient processing

- Nutritional and vitamin status

- Level and flow of amino acid

- Detoxification

- Mood issues

- Gut concerns

- Overall well-being

1-Methylhistidine

Optimal range: 88 - 394.4 nmol/mg Creatinine

2-Methylhippuric Acid

Optimal range: 0 - 2.1 nmol/mg Creatinine

2-Methylsuccinic Acid

Optimal range: 3.2 - 21.1 nmol/mg Creatinine

3,4-Dihydroxyhydrocinnamic Acid

Optimal range: 0 - 1490.3 nmol/mg Creatinine

3,5-Dihydroxybenzoic Acid

Optimal range: 0 - 277.1 nmol/mg Creatinine

3-Methylhistidine

Optimal range: 49.7 - 1852.9 nmol/mg Creatinine

3-Methylhistidine is an amino acid which is excreted in human urine.

The measurement of 3-methylhistidine provides an index of the rate of muscle protein breakdown. 3-Methylhistidine is a biomarker for meat consumption, especially chicken. It is also a biomarker for the consumption of soy products.

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3-Phenylpropionylglycine

Optimal range: 0 - 1.3 nmol/mg Creatinine

4-Hydroxybenzoic Acid

Optimal range: 0 - 14.9 nmol/mg Creatinine

4-Hydroxyphenylacetic Acid

Optimal range: 85.8 - 902.3 nmol/mg Creatinine

4-Hydroxyphenylpyruvic Acid

Optimal range: 35.5 - 1116.3 nmol/mg Creatinine

5-Hydroxyindoleacetic Acid

Optimal range: 6.3 - 28.7 nmol/mg Creatinine

8-Hydroxy-2'-deoxyguanosine

Optimal range: 0 - 8.4 nmol/mg Creatinine

a-Hydroxybutyric Acid

Optimal range: 10.6 - 62.6 nmol/mg Creatinine

a-Ketoglutaric Acid

Optimal range: 0 - 157.2 nmol/mg Creatinine

a-Ketoisovaleric Acid

Optimal range: 0 - 11.9 nmol/mg Creatinine

a-­Aminoadipic Acid

Optimal range: 4.5 - 75.3 nmol/mg Creatinine

a-­Keto-b-­methylvaleric Acid

Optimal range: 0 - 11.9 nmol/mg Creatinine

a-­Ketoglutaric Acid

Optimal range: 0 - 157.2 nmol/mg Creatinine

a-­Ketoisocaproic Acid

Optimal range: 0 - 17 nmol/mg Creatinine

Adipic Acid

Optimal range: 2 - 15.1 nmol/mg Creatinine

Alanine

Optimal range: 65.4 - 572.6 nmol/mg Creatinine

Anserine

Optimal range: 0 - 364.6 nmol/mg Creatinine

Anserine is part of a group of Beta-Amino Acids and Derivatives. Anserine is beta-alanyl-1-methyl-L-histidine, and it is known to come from chicken, turkey, duck, rabbit, tuna and salmon.

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Anthranilic Acid

Optimal range: 0 - 11.8 nmol/mg Creatinine

Arabinitol

Optimal range: 0 - 9 nmol/mg Creatinine

Arginine

Optimal range: 0 - 31.4 nmol/mg Creatinine

Arginosuccinic Acid

Optimal range: 0 - 49.7 nmol/mg Creatinine

Asparagine

Optimal range: 30.6 - 199.2 nmol/mg Creatinine

Aspartic Acid

Optimal range: 0 - 51.1 nmol/mg Creatinine

b-Hydroxybutyric Acid

Optimal range: 0 - 60.5 nmol/mg Creatinine

b-­Alanine

Optimal range: 0 - 11.8 nmol/mg Creatinine

b-­Hydroxyisovaleric Acid

Optimal range: 25.1 - 223.4 nmol/mg Creatinine

Benzoic Acid

Optimal range: 0 - 488 nmol/mg Creatinine

Benzoylform

Optimal range: 0 - 4.3 nmol/mg Creatinine

Branched Chain Alpha-Keto Organic Acids

Optimal range: 0 - 28.3 nmol/mg Creatinine

Carnosine

Optimal range: 3.9 - 70 nmol/mg Creatinine

cis-Aconitic Acid

Optimal range: 91.3 - 363.1 nmol/mg Creatinine

Citric Acid

Optimal range: 356.2 - 2000 nmol/mg Creatinine

Citrulline

Optimal range: 0 - 13.6 nmol/mg Creatinine

Cortisol

Optimal range: 0 - 82 nmol/mg Creatinine

Creatinine

Optimal range: 29.3 - 296.8 nmol/mg Creatinine

Cystathionine

Optimal range: 3.6 - 85.5 nmol/mg Creatinine

Cystine

Optimal range: 9.7 - 96.1 nmol/mg Creatinine

Equol

Optimal range: 0 - 12.8 nmol/mg Creatinine

Ethanolamine

Optimal range: 68 - 405 nmol/mg Creatinine

Ethylmalonic Acid

Optimal range: 5 - 43.3 nmol/mg Creatinine

Formiminoglutamic Acid

Optimal range: 0 - 0.4 nmol/mg Creatinine

Fructose

Optimal range: 0 - 4.7 nmol/mg Creatinine

Fumaric Acid

Optimal range: 320.2 - 3375.5 nmol/mg Creatinine

Fumarate (together with Succinate and Malate) is used in the body’s metabolic pathway that generates cellular energy – the Citric Acid Cycle.

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g-­Aminobutyric Acid

Optimal range: 0 - 0 nmol/mg Creatinine

Glucaric Acid

Optimal range: 3.6 - 25.8 nmol/mg Creatinine

Glucose

Optimal range: 0 - 15.2 mg/dL

Glutamic Acid

Optimal range: 6.5 - 83.4 nmol/mg Creatinine

Glutamic acid (or Glutamate) is a major mediator of excitatory signals in the brain and is involved in most aspects of normal brain function including cognition, memory and learning.

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Glutamine

Optimal range: 126.4 - 659.1 nmol/mg Creatinine

Glutamine / Glutamate Ratio

Optimal range: 2.5 - 39.5 nmol/mg Creatinine

- Glutamic acid has been associated with higher BMI, blood pressure, and insulin resistance, while glutamine levels were inversely associated.

- A high plasma glutamine-to-glutamic acid ratio was associated with lower risk of diabetes in the Framingham Heart Study (n=1015).

- Higher glutamine-to-glutamic acid ratio was associated with a better cardiometabolic-risk profile over 10 years in the PRIMED study (n=1879).

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Glutaric Acid

Optimal range: 0 - 4.5 nmol/mg Creatinine

Glycine

Optimal range: 248.3 - 6396 nmol/mg Creatinine

Glycylproline

Optimal range: 0 - 18.9 nmol/mg Creatinine

Hexanoylglycine

Optimal range: 0 - 2.6 nmol/mg Creatinine

Hippuric Acid

Optimal range: 0 - 291.9 nmol/mg Creatinine

Histidine

Optimal range: 126.4 - 1592.8 nmol/mg Creatinine

Homocitrulline

Optimal range: 6.1 - 43.5 nmol/mg Creatinine

Homocystine

Optimal range: 0 - 5.7 nmol/mg Creatinine

Homogentisic Acid

Optimal range: 7.9 - 336.4 nmol/mg Creatinine

Homovanillic Acid

Optimal range: 0 - 10.3 nmol/mg Creatinine

Hydroxykynurenine

Optimal range: 0 - 12.1 nmol/mg Creatinine

Hydroxyproline

Optimal range: 0 - 25.3 nmol/mg Creatinine

Indoleacetic Acid

Optimal range: 0 - 13.7 nmol/mg Creatinine

Isocitric Acid

Optimal range: 0 - 415.6 nmol/mg Creatinine

Isoleucine/allo-Isoleucine

Optimal range: 0 - 14.9 nmol/mg Creatinine

KT Ratio

Optimal range: 0.064 - 0.638 nmol/mg Creatinine

Kynurenic Acid

Optimal range: 2.1 - 18.5 nmol/mg Creatinine

Kynurenine

Optimal range: 0 - 13.7 nmol/mg Creatinine

Lactic Acid

Optimal range: 23.1 - 722.6 nmol/mg Creatinine

Leucine

Optimal range: 0 - 35.4 nmol/mg Creatinine

Lysine

Optimal range: 23.3 - 1800.4 nmol/mg Creatinine

Malic Acid

Optimal range: 0 - 21.5 nmol/mg Creatinine

Mandelic Acid

Optimal range: 0 - 4.6 nmol/mg Creatinine

Methionine

Optimal range: 0 - 11 nmol/mg Creatinine

Methylmalonic Acid

Optimal range: 2.7 - 25.9 nmol/mg Creatinine

Microalbumin

Optimal range: 0 - 130.4 nmol/mg Creatinine

Ornithine

Optimal range: 0 - 63 nmol/mg Creatinine

Orotic Acid

Optimal range: 0.7 - 6 nmol/mg Creatinine

Oxalic Acid

Optimal range: 0 - 1532.5 nmol/mg Creatinine

Phenylacetic Acid

Optimal range: 0.5 - 19.1 nmol/mg Creatinine

Phenylalanine

Optimal range: 11.7 - 73.7 nmol/mg Creatinine

Phosphate

Optimal range: 11.2 - 192.4 nmol/mg Creatinine

Phosphoethanolamine

Optimal range: 0 - 49.7 nmol/mg Creatinine

Picolinic Acid

Optimal range: 0 - 4 nmol/mg Creatinine

Pimelic Acid

Optimal range: 5.9 - 31.8 nmol/mg Creatinine

Proline

Optimal range: 0 - 14.7 nmol/mg Creatinine

Pyridoxic Acid

Optimal range: 0 - 111.9 nmol/mg Creatinine

Pyroglutamic Acid

Optimal range: 0 - 72.7 nmol/mg Creatinine

Pyruvic Acid

Optimal range: 0 - 47.2 nmol/mg Creatinine

Quercetin

Optimal range: 2.7 - 100 nmol/mg Creatinine

Quinolinic Acid

Optimal range: 9 - 105.7 nmol/mg Creatinine

Sarcosine

Optimal range: 0 - 148.3 nmol/mg Creatinine

Sarcosine is also known as N-methylglycine. It is an intermediate and byproduct in the glycine synthesis and degradation. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine-N-methyl transferase generates sarcosine from glycine.

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Serine

Optimal range: 11.7 - 724.3 nmol/mg Creatinine

Suberic Acid

Optimal range: 3 - 29.4 nmol/mg Creatinine

Suberylglycine

Optimal range: 0 - 2.3 nmol/mg Creatinine

Succinic Acid

Optimal range: 4.8 - 224.1 nmol/mg Creatinine

Sulfocysteine

Optimal range: 0 - 8.8 nmol/mg Creatinine

Tartaric Acid

Optimal range: 1.8 - 100 nmol/mg Creatinine

Taurine

Optimal range: 41.9 - 3644.8 nmol/mg Creatinine

Threonine

Optimal range: 38.3 - 402.2 nmol/mg Creatinine

Total Branched Chain Amino Acids

Optimal range: 14.3 - 105.4 nmol/mg Creatinine

Tryptophan

Optimal range: 10.5 - 68.7 nmol/mg Creatinine

Tyrosine

Optimal range: 11.4 - 126.7 nmol/mg Creatinine

Valine

Optimal range: 9.2 - 48.9 nmol/mg Creatinine

Vannilylmandelic Acid

Optimal range: 4.8 - 21.4 nmol/mg Creatinine

Xanthurenic Acid

Optimal range: 0 - 9.5 nmol/mg Creatinine
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