Mannose Binding Lectin (MBL) is a key biomarker in the innate immune system, playing a crucial role in the body's first line of defense against pathogens. It is a pattern recognition molecule that binds specifically to carbohydrate structures, such as mannose and other sugars, found on the surface of a wide range of microorganisms, including bacteria, viruses, fungi, and parasites. Upon binding, MBL activates the lectin pathway of the complement system, leading to enhanced opsonization of the pathogen, phagocytosis, and eventual lysis or clearance of the invader.
MBL deficiency or low levels can lead to increased susceptibility to infections, particularly in individuals with weakened immune systems or underlying health conditions. Low MBL levels are linked to a higher risk of recurrent respiratory infections, autoimmune diseases, and some chronic conditions. However, many people with MBL deficiency remain asymptomatic due to compensation by other immune pathways. Measuring MBL levels in blood can help assess susceptibility to infections or monitor immune system health, especially in immunocompromised patients. Research into MBL is also exploring its potential role in conditions such as sepsis, chronic inflammation, and even cardiovascular diseases. While there are no specific treatments for MBL deficiency, managing infections and supporting immune health through preventive measures like vaccines and proper hygiene can help reduce the risk of complications.
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What does it mean if your Mannose Binding Lectin (MBL) result is too low?
Low levels of Mannose Binding Lectin (MBL) are often associated with an increased susceptibility to infections, particularly in individuals with compromised or underdeveloped immune systems. People with low MBL levels may experience recurrent bacterial, viral, or fungal infections, especially in the respiratory and gastrointestinal tracts. In some cases, low MBL levels can also be linked to more severe infections or complications like sepsis, autoimmune diseases, or chronic inflammatory conditions. However, many people with low MBL levels remain asymptomatic because other components of the immune system can compensate for the deficiency.
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
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