3301 Organix Comprehensive Profile - Urine (mmol/mol creatinine)

The Organix Comprehensive Profile is a nutritional test providing insights into organic acids and a view into the body's cellular metabolic processes. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize responses and lead to improved outcomes.

 

3,4-Dihydroxyphenylpropionate

Optimal range: 0 - 5.3 mmol/mol creatinine

3-Methyl-4-OH-phenylglycol

Optimal range: 0.02 - 0.22 mmol/mol creatinine

5-Hydroxyindoleacetate

Optimal range: 3.8 - 12.1 mmol/mol creatinine

5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors.

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8-Hydroxy-2-deoxyguanosine

Optimal range: 0 - 15 mmol/mol creatinine

a-Hydroxybutyrate

Optimal range: 0 - 0.83 mmol/mol creatinine

a-Hydroxyisobutyrate

Optimal range: 0 - 6.7 mmol/mol creatinine

a-Keto-b-Methylvalerate

Optimal range: 0 - 2.1 mmol/mol creatinine

a-Ketoadipate

Optimal range: 0 - 1.7 mmol/mol creatinine

a-Ketoglutarate

Optimal range: 4 - 52 mmol/mol creatinine

a-Ketoisocaproate

Optimal range: 0 - 0.89 mmol/mol creatinine

a-Ketoisovalerate

Optimal range: 0 - 0.97 mmol/mol creatinine

a-Ketophenylacetate

Optimal range: 0 - 0.46 mmol/mol creatinine

Adipate

Optimal range: 0 - 2.8 mmol/mol creatinine

b-Hydroxybutyrate

Optimal range: 0 - 2.8 mmol/mol creatinine

ß-Hydroxybutyrate is a metabolic marker of blood sugar utilization and insulin function.

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b-Hydroxyisovalerate

Optimal range: 0 - 29 mmol/mol creatinine

b-Hydroxypropionate

Optimal range: 5 - 22 mmol/mol creatinine

Benzoate

Optimal range: 0 - 0.05 mmol/mol creatinine

Benzoate, was one of the compounds first found to be elevated in urine from patients with intestinal bacterial overgrowth of various origins.

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Cis-Aconitate

Optimal range: 10 - 36 mmol/mol creatinine

cis-Aconitate is involved in both energy production and removal of toxic ammonia.

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Citramalate

Optimal range: 0 - 5.8 mmol/mol creatinine

Citrate

Optimal range: 40 - 520 mmol/mol creatinine

D-Arabinitol

Optimal range: 0 - 36 mmol/mol creatinine

Formiminoglutamate

Optimal range: 0 - 1.5 mmol/mol creatinine

Formiminoglutamate (FIGLU) is a functional marker of insufficiency of folic acid, another B-vitamin, and is a compound made from the amino acid histidine.

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Glutarate

Optimal range: 0 - 0.51 mmol/mol creatinine

Glycerate

Optimal range: 3.5 - 16.4 mmol/mol creatinine

Glycolate

Optimal range: 0 - 67 mmol/mol creatinine

Glycolate is one of the oxalate markers.

Glycolic acid (glycolate) is an indicator of genetic disease of oxalate metabolism called Hyperoxaluria type I due to a deficiency in the enzyme activity of alanine glyoxylate amino transferase (AGT).

Oxalate (and its acid form, oxalic acid), is an organic acid that is primarily derived from three sources: the diet, fungus (such as Aspergillus and Penicillium), possibly Candida, and also human metabolism.

Oxalic acid is the most acidic organic acid in body fluids and is used commercially to remove rust from car radiators. Antifreeze (ethylene glycol) is toxic primarily because it is converted to oxalate in the body. Two different types of genetic diseases are known in which oxalates are high in the urine, hyperoxalurias type I and type II.

In the genetic disease hyperoxaluria type I and in vitamin B-6 deficiency, there is a deficiency in the enzyme activity of alanine glyoxylate amino transferase (AGT), leading to the accumulation of glyoxylic acid. The high glyoxylic acid can then be converted to glycolate by the enzyme GRHPR or to oxalate by the enzyme LDH. Thus, glycolate, glyoxylate, and oxalate are the metabolites that are then elevated in the Organic Acids Test in hyperoxaluria type I and in vitamin B-6 deficiency. 

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Hippurate

Optimal range: 0 - 603 mmol/mol creatinine

Homovanillate

Optimal range: 1.2 - 5.3 mmol/mol creatinine

Hydroxymethylglutarate

Optimal range: 0 - 15 mmol/mol creatinine

Indoleacetate

Optimal range: 0 - 4.2 mmol/mol creatinine

Isocitrate

Optimal range: 22 - 65 mmol/mol creatinine

Isovalerylglycine

Optimal range: 0 - 3.7 mmol/mol creatinine

Kynurenate

Optimal range: 0 - 7.1 mmol/mol creatinine

Kynurenate/Quinolinate

Optimal range: 0.44 - 5 mmol/mol creatinine

Lactate

Optimal range: 1.9 - 19.8 mmol/mol creatinine

m-Hydroxyphenylacetate

Optimal range: 0 - 8.1 mmol/mol creatinine

Malate

Optimal range: 0 - 3 mmol/mol creatinine

Methylmalonate

Optimal range: 0 - 1.9 mmol/mol creatinine

Orotate

Optimal range: 0.33 - 1.01 mmol/mol creatinine

Oxalate

Optimal range: 0 - 78 mmol/mol creatinine

p-Hydroxyphenylacetate

Optimal range: 0 - 29 mmol/mol creatinine

Phenylacetate

Optimal range: 0 - 0.12 mmol/mol creatinine

Produced from bacterial degradation of unabsorbed phenylalanine.

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Pyroglutamate

Optimal range: 16 - 34 mmol/mol creatinine

Pyruvate

Optimal range: 7 - 32 mmol/mol creatinine

Quinolinate

Optimal range: 0 - 9.1 mmol/mol creatinine

Suberate

Optimal range: 0 - 2.1 mmol/mol creatinine

Succinate

Optimal range: 0.4 - 4.6 mmol/mol creatinine

Tartarate

Optimal range: 0 - 15 mmol/mol creatinine

Vanilmandelate

Optimal range: 0.4 - 3.6 mmol/mol creatinine

Xanthurenate

Optimal range: 0 - 0.96 mmol/mol creatinine