3301 Organix Comprehensive Profile - Urine (mmol/mol creatinine)
The Organix Comprehensive Profile is a nutritional test providing insights into organic acids and a view into the body's cellular metabolic processes. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize responses and lead to improved outcomes.
5-HydroxyindoleacetateOptimal range: 3.8 - 12.1 mmol/mol creatinine
5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors.LEARN MORE
b-HydroxybutyrateOptimal range: 0 - 2.8 mmol/mol creatinine
ß-Hydroxybutyrate is a metabolic marker of blood sugar utilization and insulin function.LEARN MORE
BenzoateOptimal range: 0 - 0.05 mmol/mol creatinine
Benzoate, was one of the compounds first found to be elevated in urine from patients with intestinal bacterial overgrowth of various origins.LEARN MORE
Cis-AconitateOptimal range: 10 - 36 mmol/mol creatinine
cis-Aconitate is involved in both energy production and removal of toxic ammonia.LEARN MORE
FormiminoglutamateOptimal range: 0 - 1.5 mmol/mol creatinine
Formiminoglutamate (FIGLU) is a functional marker of insufficiency of folic acid, another B-vitamin, and is a compound made from the amino acid histidine.LEARN MORE
GlycolateOptimal range: 0 - 67 mmol/mol creatinine
Glycolate is one of the oxalate markers.
Glycolic acid (glycolate) is an indicator of genetic disease of oxalate metabolism called Hyperoxaluria type I due to a deficiency in the enzyme activity of alanine glyoxylate amino transferase (AGT).
Oxalate (and its acid form, oxalic acid), is an organic acid that is primarily derived from three sources: the diet, fungus (such as Aspergillus and Penicillium), possibly Candida, and also human metabolism.
Oxalic acid is the most acidic organic acid in body fluids and is used commercially to remove rust from car radiators. Antifreeze (ethylene glycol) is toxic primarily because it is converted to oxalate in the body. Two different types of genetic diseases are known in which oxalates are high in the urine, hyperoxalurias type I and type II.
In the genetic disease hyperoxaluria type I and in vitamin B-6 deficiency, there is a deficiency in the enzyme activity of alanine glyoxylate amino transferase (AGT), leading to the accumulation of glyoxylic acid. The high glyoxylic acid can then be converted to glycolate by the enzyme GRHPR or to oxalate by the enzyme LDH. Thus, glycolate, glyoxylate, and oxalate are the metabolites that are then elevated in the Organic Acids Test in hyperoxaluria type I and in vitamin B-6 deficiency.LEARN MORE
PhenylacetateOptimal range: 0 - 0.12 mmol/mol creatinine
Produced from bacterial degradation of unabsorbed phenylalanine.LEARN MORE