3301 Organix Comprehensive Profile - Urine (mmol/mol creatinine)
The Organix Comprehensive Profile is a nutritional test providing insights into organic acids and a view into the body's cellular metabolic processes. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize responses and lead to improved outcomes.
3,4-Dihydroxyphenylpropionate
Optimal range: 0 - 5.3 mmol/mol creatinine3-Methyl-4-OH-phenylglycol
Optimal range: 0.02 - 0.22 mmol/mol creatinine5-Hydroxyindoleacetate
Optimal range: 3.8 - 12.1 mmol/mol creatinine
5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors.
LEARN MORE8-Hydroxy-2-deoxyguanosine
Optimal range: 0 - 15 mmol/mol creatininea-Hydroxybutyrate
Optimal range: 0 - 0.83 mmol/mol creatininea-Hydroxyisobutyrate
Optimal range: 0 - 6.7 mmol/mol creatininea-Keto-b-Methylvalerate
Optimal range: 0 - 2.1 mmol/mol creatininea-Ketoadipate
Optimal range: 0 - 1.7 mmol/mol creatininea-Ketoglutarate
Optimal range: 4 - 52 mmol/mol creatininea-Ketoisocaproate
Optimal range: 0 - 0.89 mmol/mol creatininea-Ketoisovalerate
Optimal range: 0 - 0.97 mmol/mol creatininea-Ketophenylacetate
Optimal range: 0 - 0.46 mmol/mol creatinineAdipate
Optimal range: 0 - 2.8 mmol/mol creatinineb-Hydroxybutyrate
Optimal range: 0 - 2.8 mmol/mol creatinineb-Hydroxyisovalerate
Optimal range: 0 - 29 mmol/mol creatinineb-Hydroxypropionate
Optimal range: 5 - 22 mmol/mol creatinineBenzoate
Optimal range: 0 - 0.05 mmol/mol creatinine
Benzoate, was one of the compounds first found to be elevated in urine from patients with intestinal bacterial overgrowth of various origins.
LEARN MORECis-Aconitate
Optimal range: 10 - 36 mmol/mol creatinineCitramalate
Optimal range: 0 - 5.8 mmol/mol creatinineCitrate
Optimal range: 40 - 520 mmol/mol creatinineD-Arabinitol
Optimal range: 0 - 36 mmol/mol creatinineFormiminoglutamate
Optimal range: 0 - 1.5 mmol/mol creatinine
Formiminoglutamate (FIGLU) is a functional marker of insufficiency of folic acid, another B-vitamin, and is a compound made from the amino acid histidine.
LEARN MOREGlutarate
Optimal range: 0 - 0.51 mmol/mol creatinineGlycerate
Optimal range: 3.5 - 16.4 mmol/mol creatinineGlycolate
Optimal range: 0 - 67 mmol/mol creatinine
Glycolate is one of the oxalate markers.
Glycolic acid (glycolate) is an indicator of genetic disease of oxalate metabolism called Hyperoxaluria type I due to a deficiency in the enzyme activity of alanine glyoxylate amino transferase (AGT).
Oxalate (and its acid form, oxalic acid), is an organic acid that is primarily derived from three sources: the diet, fungus (such as Aspergillus and Penicillium), possibly Candida, and also human metabolism.
Oxalic acid is the most acidic organic acid in body fluids and is used commercially to remove rust from car radiators. Antifreeze (ethylene glycol) is toxic primarily because it is converted to oxalate in the body. Two different types of genetic diseases are known in which oxalates are high in the urine, hyperoxalurias type I and type II.
In the genetic disease hyperoxaluria type I and in vitamin B-6 deficiency, there is a deficiency in the enzyme activity of alanine glyoxylate amino transferase (AGT), leading to the accumulation of glyoxylic acid. The high glyoxylic acid can then be converted to glycolate by the enzyme GRHPR or to oxalate by the enzyme LDH. Thus, glycolate, glyoxylate, and oxalate are the metabolites that are then elevated in the Organic Acids Test in hyperoxaluria type I and in vitamin B-6 deficiency.
LEARN MOREHippurate
Optimal range: 0 - 603 mmol/mol creatinineHomovanillate
Optimal range: 1.2 - 5.3 mmol/mol creatinineHydroxymethylglutarate
Optimal range: 0 - 15 mmol/mol creatinine
Hydroxymethylglutarate (HMG) is the precursor to Coenzyme Q10 (CoQ10) production, and when it is elevated it may indicate that the body is trying to increase its production of CoQ10.
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