Wheat/Gluten Proteome Reactivity & Autoimmunity (Cyrex Laboratories)

Clinical Use:

- Identify possible Celiac disease, non-celiac gluten sensitivity, dermatitis herpetiformis, gluten ataxia or other wheat/gluten-related disorder.

- Assess autoimmune reactivity associated with wheat proteins and peptides.

Recommended for Patients who:

- have non-responsive GI symptoms

- present multiple-symptom complaints (including Chronic Fatigue Syndrome and Fibromyalgia)

- suffer from depression or neuro-autoimmunity

Alpha-Gliadin-17-mer IgA

Optimal range: 0.2 - 1.5 ELISA Index

Alpha-Gliadin-17-mer IgG

Optimal range: 0.2 - 1.8 ELISA Index

Gamma-Gliadin-15-mer IgA

Optimal range: 0.1 - 1.5 ELISA Index

Gamma-Gliadin-15-mer IgG

Optimal range: 0 - 1.2 ELISA Index

Gliadin Toxic Peptides IgA

Optimal range: 0.1 - 1.5 ELISA Index

Gliadin Toxic Peptides IgG

Optimal range: 0.1 - 1.7 ELISA Index

Gliadin-Transglutaminase Complex IgA

Optimal range: 0.2 - 1.6 ELISA Index

The wheat tested is the full kernel containing the protein constituents of wheat. This includes what may be on or in the wheat kernel. These are gluten proteins, and non-gluten proteins (non-gluten proteins A and B and Wheat Germ Agglutinins). A positive result to wheat means that your digestive system is not absorbing these proteins well, therefore your immune system starts producing antibodies to gluten or non-gluten part(s) of wheat.

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Gliadin-Transglutaminase Complex IgG

Optimal range: 0 - 1.3 ELISA Index

The wheat tested is the full kernel containing the protein constituents of wheat. This includes what may be on or in the wheat kernel. These are gluten proteins, and non-gluten proteins (non-gluten proteins A and B and Wheat Germ Agglutinins). A positive result to wheat means that your digestive system is not absorbing these proteins well, therefore your immune system starts producing antibodies to gluten or non-gluten part(s) of wheat.

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Glutenin-21-mer IgA

Optimal range: 0 - 1.1 ELISA Index

Glutenin-21-mer IgG

Optimal range: 0.2 - 1.5 ELISA Index

Gluteomorphin+Prodynorphin IgA

Optimal range: 0.3 - 2.4 ELISA Index

Gluteomorphin+Prodynorphin IgG

Optimal range: 0 - 2.2 ELISA Index

Microbial Transglutaminase IgA

Optimal range: 0.5 - 2.1 ELISA Index

Microbial Transglutaminase is not made by the human body, it is made by bacteria and is used in the food and drug industry. It is capable of cross reacting with the Gliadin-Transglutaminase complex. Those antibodies may trigger autoimmune reactivity.

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Microbial Transglutaminase IgG

Optimal range: 0.1 - 2 ELISA Index

Microbial Transglutaminase is not made by the human body, it is made by bacteria and is used in the food and drug industry. It is capable of cross reacting with the Gliadin-Transglutaminase complex. Those antibodies may trigger autoimmune reactivity.

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Non-Gluten Proteins-A IgA

Optimal range: 0 - 1.8 ELISA Index

Non-Gluten Proteins-A IgG

Optimal range: 0 - 1.3 ELISA Index

Non-Gluten Proteins-B IgA

Optimal range: 0.1 - 0.8 ELISA Index

Non-Gluten Proteins-B IgG

Optimal range: 0 - 1.3 ELISA Index

Omega-Gliadin-17-mer IgA

Optimal range: 0.2 - 1.7 ELISA Index

Omega-Gliadin-17-mer IgG

Optimal range: 0 - 1.4 ELISA Index

Transglutaminase-2 IgA

Optimal range: 0.3 - 2.1 ELISA Index

Transglutaminase-2 IgG

Optimal range: 0 - 1.4 ELISA Index

Tissue Transglutaminase-2 (tTG2) -- Transglutaminases are enzymes with multiple functions. One of the key functions is to build tissue structures. tTG2 is found throughout the body, but is the predominant enzyme in the intestinal villi. This makes it a preferred biomarker for possible Celiac disease.

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Transglutaminase-3 IgA

Optimal range: 0.1 - 1.8 ELISA Index

Transglutaminase-3 IgG

Optimal range: 0 - 1.4 ELISA Index

Tissue Transglutaminase-3 (tTG3) -- The transglutaminase found in skin and hair shaft follicles is tTG3. In some individuals, the ingestion of gluten causes eruptions on the skin known as dermatitis herpetiformis. Adherence to the gluten-free diet can clear the skin of these eruptions.

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Transglutaminase-6 IgA

Optimal range: 0.4 - 2 ELISA Index

Tissue Transglutaminase-6 (tTG6) -- The transglutaminase found in the brain and nervous system is tTG6. In some individuals, the ingestion of gluten causes neurological manifestations, such as gluten ataxia (walking or balance disorder) or peripheral neuropathy (tingling in the legs or feet). Adherence to the gluten-free diet can improve these neurological conditions.

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Transglutaminase-6 IgG

Optimal range: 0 - 1.2 ELISA Index

Tissue Transglutaminase-6 (tTG6) -- The transglutaminase found in the brain and nervous system is tTG6. In some individuals, the ingestion of gluten causes neurological manifestations, such as gluten ataxia (walking or balance disorder) or peripheral neuropathy (tingling in the legs or feet). Adherence to the gluten-free diet can improve these neurological conditions.

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Wheat Germ Agglutinin IgA

Optimal range: 0 - 1.6 ELISA Index

Wheat Germ Agglutinin is not gluten, but is found in whole grain wheat. If your test results are positive (higher than normal levels of antibodies) the most logical suggestion is to not eat whole grain wheat and to be certain other wheat derived foods are not Wheat Germ Agglutinin contaminated.

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Wheat Germ Agglutinin IgG

Optimal range: 0 - 1 ELISA Index

Wheat Germ Agglutinin is not gluten, but is found in whole grain wheat. If your test results are positive (higher than normal levels of antibodies) the most logical suggestion is to not eat whole grain wheat and to be certain other wheat derived foods are not Wheat Germ Agglutinin contaminated.

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Wheat IgA

Optimal range: 0 - 1.7 ELISA Index

Wheat IgG

Optimal range: 0 - 1.8 ELISA Index