GI360 stool profile
StoolPerformed by: Doctor's Data
Comprehensive Guide to the GI360® by Doctor’s Data: Revolutionizing Gut Health Diagnostics
The GI360® Stool Profile by Doctor’s Data is a cutting-edge diagnostic tool designed to provide a detailed analysis of gut health. Utilizing advanced technologies like multiplex PCR, culture techniques, and biochemical testing, the GI360® offers actionable insights into the gut microbiome, digestive function, and intestinal health. This comprehensive stool test is ideal for identifying the root causes of gastrointestinal (GI) symptoms and systemic health conditions linked to gut imbalances.
What Makes the GI360® Unique?
The GI360® combines state-of-the-art methodologies to deliver a complete picture of gut health, enabling personalized treatment plans for improved digestive and systemic health. Key features include:
- Microbiome Analysis with Multiplex PCR Technology: Provides a detailed evaluation of gut microbial composition and diversity, pinpointing imbalances in beneficial and pathogenic bacteria, fungi, and viruses.
- Pathogen Detection: Identifies bacterial, viral, and parasitic pathogens that may contribute to gastrointestinal infections.
- Digestive Function Markers: Measures biomarkers such as elastase, fat, and muscle fibers to assess digestive efficiency.
- Inflammation and Immunity Assessment: Includes biomarkers like calprotectin and secretory IgA to evaluate inflammation and immune response in the gut.
- Comprehensive Culture Testing: Assesses anaerobic and aerobic bacteria to provide insight into microbial overgrowth or dysbiosis.
Who Benefits from the GI360®?
This advanced stool test is invaluable for individuals experiencing persistent gastrointestinal symptoms or systemic health issues potentially linked to the gut. Common conditions addressed by the GI360® include:
Gastrointestinal Symptoms
- Chronic diarrhea or constipation
- Gas and bloating
- Abdominal pain
- Indigestion or reflux
- Irregular bowel movements
Systemic Health Concerns
- Irritable Bowel Syndrome (IBS)
- Inflammatory Bowel Disease (IBD)
- Food intolerances or allergies
- Autoimmune diseases
- Mood disorders like anxiety and depression
- Skin conditions such as eczema or psoriasis
- Metabolic conditions including obesity and diabetes
The Gut Microbiome and Its Impact on Overall Health
The gut microbiome plays a central role in maintaining overall health. Imbalances, also known as dysbiosis, have been linked to a wide range of health concerns, including immune dysfunction, chronic inflammation, and mental health challenges. The GI360® provides an in-depth analysis of the microbiome, helping healthcare providers identify dysbiosis and develop targeted treatment strategies to restore balance.
Key Biomarkers in the GI360® Profile
The GI360® evaluates a comprehensive panel of biomarkers to deliver actionable insights, including:
- Calprotectin: A marker of inflammation, aiding in the differentiation between IBD and IBS.
- Beta-glucuronidase: Provides insights into detoxification and estrogen metabolism.
- Elastase: Measures pancreatic function, critical for proper digestion.
- Short-Chain Fatty Acids (SCFAs): Evaluates microbial fermentation and gut health.
- Secretory IgA (sIgA): Assesses immune function within the gut.
Why Choose the GI360® by Doctor’s Data?
- Advanced Diagnostics: Combines the latest in molecular and culture-based testing for comprehensive insights.
- Tailored Treatment Plans: Helps healthcare providers create personalized strategies to address GI symptoms and improve overall health.
- Broad Applications: Supports diagnosis and management of gut-related and systemic health conditions.
Take Control of Your Gut Health with the GI360®
Your gut is the foundation of your overall health, and the GI360® by Doctor’s Data offers the tools you need to understand and optimize it. Whether you’re dealing with chronic digestive issues or systemic conditions linked to gut health, this comprehensive stool profile provides the insights needed to make informed health decisions.
Speak to your healthcare provider today about the GI360® and start your journey toward better gut health and overall wellness.
Show more
Biomarkers included in this panel:
Acinetobacter junii is rarely a cause of disease in humans. A. junii has mainly been associated with bacteremia in preterm infants and pediatric oncologic patients. Acinetobacter junii is one of more than 50 different species belonging to the genu
Learn moreActinobacteria is one of the largest bacterial phyla, comprised of Gram-positive bacteria.
Learn moreActinomycetales are considered low abundance colonizers of the gastrointestinal tract with primary residence on the skin.
Learn moreAdenoviruses are non-enveloped DNA viruses. Adenovirus is a cause of acute gastroenteritis in infants, young children, the elderly and immuno-compromised patients. The Adenovirus serotypes most frequently associated with gastroenteritis are Adenov
Learn moreAkkermansia muciniphila may represent 3–5% of the microbial composition in the healthy human intestinal tract, and have a crucial role in the regulation of the gut barrier and other homeostatic and metabolic functions.
Learn more- Alistipes does not contribute significantly to short chain fatty acid production. - A diet rich in animal protein and fat increases the abundance of Alistipes. - High abundance of Alistipes was identified as a possible predictor of successful
Learn moreAlistipes does not contribute significantly to short chain fatty acid production. A diet rich in animal protein and fat increases the abundance of Alistipes. High abundance of Alistipes was identified as a possible predictor of successful weight loss
Learn moreAscaris is a worm that infects the small intestine, but its life cycle includes migration through the circulation to the heart and lungs, and into the oropharynx. Infection is acquired through the ingestion of embryonated eggs in contaminated soil or
Learn moreThe phylum Firmicutes constitutes the most diverse and abundant group of gastrointestinal microbiota which are grouped into four classes, Bacilli, Clostridia, Erysipelotrichi, and Negativicutes. They make up approximately 39% of the gut microbiota, o
Learn moreImbalanced bacteria are usually neither pathogenic nor beneficial to the host GI tract. Imbalances can occur when there are insufficient levels of beneficial bacteria and increased levels of commensal bacteria. Certain commensal bacteria are reported
Learn moreSpecies in the genus Bacteroides carry out broad metabolic functions, including degradation of complex plant polysaccharides, proteolytic activities, de-conjugation of bile acids, mucosal barrier integrity, short chain fatty acid production, fatty ac
Learn moreBacteroides pectinophilus contributes to breakdown of dietary pectins which are prebiotics. Pectins are complex, plantderived carbohydrates that are indigestible by human enzymes, but can be easily degraded by certain commensal bacteria in the gut.
Learn moreSpecies in the genus Bacteroides carry out broad metabolic functions, including degradation of complex plant polysaccharides, proteolytic activities, de-conjugation of bile acids, mucosal barrier integrity, short chain fatty acid production, fatty ac
Learn moreThe predominant genera in the human colonic microbiota are Bacteroides and Prevotella, which belong to the major phyla Bacteroidetes.
Learn moreSpecies in the genus Bacteroides carry out broad metabolic functions, including degradation of complex plant polysaccharides, proteolytic activities, de-conjugation of bile acids, mucosal barrier integrity, short chain fatty acid production, fatty ac
Learn moreBacteroides zoogleoformans is part of the Bacteroides genus. Species in the genus Bacteroides carry out broad metabolic functions, including: - degradation of complex plant polysaccharides, - proteolytic activities (=the breakdown of prote
Learn moreConsidered amongst the most beneficial commensal bacteria in the human gut, Bifidobacterium spp. are able to degrade monosaccharides, galacto-, manno-, and fructo-oligosaccharides, as well as some complex carbohydrates. Many of the non-digestible oli
Learn moreMost Campylobacter infections in industrialized countries are caused by C. jejuni, C. coli, and C. lari with an estimated 1.5 million cases of foodborne illness due to Campylobacter per year in the US. Campylobacter spp. are responsible for approxima
Learn moreSimple sugars are absorbed in the small intestine and should not be appreciably present in the colon because they are a primary energy source for pathogenic or dysbiotic bacteria and yeast.
Learn moreConsumption of a Western diet has been shown to increase Catenibacterium mitsuokai in the human gut microbiota. Catenibacterium mitsuokai ferments glucose, mannose, galactose, fructose, sucrose, maltose, cellobiose, lactose and salicin in the prod
Learn moreCharcot-Leyden crystals are formed from the breakdown of immune cells, especially eosinophils, and may be seen in the stool of patients with parasitic diseases. The crystals are indicative of immune response and can sometimes be seen in association w
Learn moreCitrobacter spp., a gram-negative bacterium and member of the Enterobacteriaceae family, is considered dysbiotic at 3+ or greater. Citrobacter freundii complex (including C. freundii, C. braakii, C. gullenii, C. murliniae, rodentium, C. wermanii, C.
Learn moreCitrobacter spp., a gram-negative bacterium and member of the Enterobacteriaceae family, is considered dysbiotic at 3+ or greater. Citrobacter freundii complex (including C. freundii, C. braakii, C. gullenii, C. murliniae, rodentium, C. wermanii,
Learn moreThis trematode infects the bile ducts. Infection occurs through consumption of encysted metacercariae in raw, dried, or pickled fish imported from endemic areas, which include Japan, Korea, China, Taiwan, and Vietnam. Light infection is usually as
Learn moreMarkers in this class are important producers of short-chain fatty acids, and have many well-documented roles in promoting a healthy intestinal barrier, immune balance, and protection against pathogens.
Learn moreC. difficile may cause diarrhea following the production of two toxins, enterotoxin A and cytotoxin B. C. difficile is the most common cause of nosocomial infectious diarrhea in developed countries and is the major cause of antibiotic-associated
Learn moreAppropriate digestion and metabolism of complex dietary carbohydrates from plants drives healthy diversity in the gut microbiota. Clostridium methylpentosum ferments the naturally occurring sugar L-rhamnose that is released by microbial breakdown of
Learn moreStool is normally brown because of pigments formed by bacteria acting on bile introduced into the digestive system from the liver. While certain conditions can cause changes in stool color, many changes are harmless and are caused by pigments in food
Learn moreStool normally contains about 75% water and ideally should be formed and soft. Stool consistency can vary based upon transit time and water absorption.
Learn moreCoprobacillus cateniformis ferment glucose and other common sugars primarily to acetic and lactic acid, and to a lesser extent butyrate and valerate.
Learn moreThe Cryptosporidium parasite causes disease in humans through ingestion of infectious oocysts in contaminated water or food, and by direct contact with fecal material from individuals or animals actively shedding oocysts. Two species of Cryptosporidi
Learn moreDialister invisus is generally considered an endodontic pathogen (Endo is the Greek word for inside and odont is Greek for tooth). Dialister invisus is often associated with periodontitis, caries, halitosis, and endodontic in
Learn moreDialister invisus is generally considered an endodontic pathogen (Endo is the Greek word for inside and odont is Greek for tooth). Dialister invisus is often associated with periodontitis, caries, halitosis, and endodontic in
Learn moreD. fragilis infects the large intestine. This parasite does not have a cyst stage, and cannot survive long outside the body alone. It may be spread in pinworm (Enterobius vermicularis) eggs. Infection is common worldwide, including in the United Stat
Learn moreDorea is a genus within the Lachnospiraceae family that is in the Firmicutes phylum. Dorea species are known to produce hydrogen and carbon dioxide as end-products of glucose fermentation and may be associated with bloating.
Learn moreElastase is a pancreatic enzyme that digests and degrades a number of proteins. A finding of low elastase in a formed stool specimen is an indicator of pancreatic exocrine insufficiency. Moderate pancreatic insufficiency is defined at 100-200 μg/m
Learn moreEntamoeba histolytica is a protozoan parasite that infects an estimated 34 to 50 million people per year worldwide, and kills 100,000 individuals annually. The disease caused by E. histolytica, amebiasis, is common in tropical areas with poor sanitar
Learn moreEnterobacter cloacae complex is part of the Enterobacteriaceae family. E cloacae complex is a group of six closely related species with similar resistance patterns: E. cloacae, E. asburiae, E. hormaechei, E. kobei, E. ludwigii, and E. nimipressura
Learn moreEnterobacteriaceae is a large family of bacteria within the Proteobacteria phyla. Enterobacteriaceae is inclusive of normal commensal species, harmless opportunists, and many of the more familiar pathogens, such as Salmonella, Escherichia coli, Klebs
Learn moreThis nematode inhabits the large intestine and migrates to the anus at night, where it deposits eggs on the perianal surface. Pinworm is the most common worm infection in the United States. School-age children, followed by preschoolers, have the high
Learn moreETEC is a major cause of traveler’s diarrhea in adults in industrialized countries and a leading cause of infant diarrhea in developing countries. ETEC is estimated to cause 200 million episodes of diarrhea and approximately 380,000 deaths in c
Learn moreE. coli O157 is a member of the pathogenic enterohemorrhagic E. coli strains (also known as verocytotoxin producing or Shiga-toxin producing E. coli (STEC)), and is an uncommon but serious cause of gastroenteritis. Infection with E. coli O157 often c
Learn moreEubacterium hallii and Eubacterium rectale are both part of the Lachnospiraceae family that is in the Firmicutes phylum.
Learn moreFaecalibacterium prausnitzii is one of the most abundant butyrate producing bacteria in a healthy gastrointestinal tract.
Learn moreIndividuals who have pancreatic insufficiency secondary to pancreatic or biliary tract disease may be unable to efficiently digest and absorb fat normally. The microscopic fecal fat test is a reliable marker for fat malabsorption, and evaluation enzy
Learn moreGram-negative Bacteroidetes and grampositive Firmicutes are bacterial phyla that dominate the entire human digestive tract, including the mouth, nose, throat, and colon.2 An abnormal result in one or both of these phylum suggest imbalanced normal mic
Learn moreG. duodenalis, a single celled protozoa, is the most frequent cause of non-bacterial diarrhea in the United States. The Centers for Disease Control and Prevention (CDC) estimates as many as 2.5 million cases of Giardia infection occur annually in the
Learn moreThe adult nematodes attach to the wall of the small intestine and suck blood. The hookworm life cycle also includes migration through the circulation to the heart and lungs, and into the oropharynx. Infection occurs when larvae from fecally-contamina
Learn moreIodamoeba buetschlii is considered nonpathogenic or commensal. Infection occurs via fecal-oral route, and indicates increased risk of exposure to potential pathogens.
Learn moreKlebsiella spp. are gram-negative bacilli belonging to the Enterobacteriaceae family and closely related to the genera Enterobacter and Serratia. Klebsiella spp. are considered dysbiotic in the amount of 3 - 4 +. Klebsiella spp. are widely distribute
Learn moreKlebsiella spp. are gram-negative bacilli belonging to the Enterobacteriaceae family and closely related to the genera Enterobacter and Serratia. Klebsiella spp. are widely distributed in nature and in the gastrointestinal tract of humans. In humans,
Learn moreThe Lachnospiraceae family is a diverse group of butyric acid producers, which have been associated with beneficial microbial and epithelial cell growth. Consumption of a Mediterranean diet decreased levels of species belonging to Lachnospiraceae.
Learn moreDecreased and normal levels of Lactobacillus spp. have been reported in patients with irritable bowel syndrome. Lactobacillus spp. abundance was shown to be lower in the active phase of ulcerative colitis. Lactobacillus levels were shown to be increa
Learn moreLactobacillus species is a type of bacteria. There are lots of different species of lactobacillus. Lactobacillus bacteria are commonly found in the human gut, mouth and vagina. They are considered generally as “good bacteria”
Learn moreThe presence of mucus in the stool may be due to prolonged irritation to the intestinal mucosa and may be secondary to a proliferation of gastrointestinal enteropathogens such as bacteria, yeast, or parasites. It can also be associated with an inflam
Learn moreMuscle fibers in the stool are an indicator of incomplete digestion. Bloating, flatulence, feelings of “fullness” may be associated with increase in muscle fibers. The presence of muscle fibers in the stool is an indicator of incomplet
Learn moreMycoplasma hominis is from the Tenericutes phylum. Tenericutes are cell wall-less bacteria that do not synthesize precursors of peptidoglycan. Tenericutes consist of four main clades designated as the Acholeplasma, Spiroplasma, Pneumoniae and Homi
Learn moreNorovirus affects people of all ages causing 19 to 21 million illnesses in the US per year. It is the leading contributor to acute gastroenteritis (AGE) across all age groups. While infections can occur year-round, Norovirus outbreaks tend to peak in
Learn moreIn many cases, a positive occult blood results from gastrointestinal bleeding from the upper small intestine or higher. Gastric ulceration could, for example, result in a finding of occult blood rather than blood in the feces. However, a positive fin
Learn moreThe abundance of Parabacteroides spp., major anaerobic producers of acetate and succinate is increased with a high fat diet and is positively correlated with body weight. Parabacteroides spp., along with certain Bacteroides spp., have been shown to d
Learn moreThe abundance of Parabacteroides spp., major anaerobic producers of acetate and succinate is increased with a high fat diet and is positively correlated with body weight. Parabacteroides spp., along with certain Bacteroides spp., have been shown to d
Learn moreP. hominis is considered nonpathogenic or commensal. It lives in the large intestine. Exposure occurs via fecal-oral route, and indicates increased risk of exposure to potential pathogens.
Learn morePhascolarctobacterium faecium can produce short-chain fatty acids, including acetate and propionate, and may be associated with metabolic effects and mental state of the host.
Learn moreProteobacteria (phylum) Proteobacteria include a wide variety of pathogens, including species within the Escherichia, Shigella Salmonella, Vibrio, and Helicobacter genera. The phylum includes a number of species that are permanent residents of the
Learn moreRed Blood Cells (RBC) in the stool may be associated with a parasitic or bacterial infection, or an inflammatory bowel condition such as ulcerative colitis. Colorectal cancer, anal fistulas, and hemorrhoids should also be ruled out.
Learn moreRotaviruses are classified into seven serogroups (A-G); however, only groups A, B, and C are human pathogens. The Group A Rotaviruses are responsible for the majority of infections. Globally, Rotavirus is estimated to cause more than 125 mill
Learn moreImbalanced bacteria are usually neither pathogenic nor beneficial to the host GI tract. Imbalances can occur when there are insufficient levels of beneficial bacteria and increased levels of commensal bacteria. Certain commensal bacteria are reported
Learn moreMembers of Ruminococcus sensu produce acetate, but not butyrate. Ruminococcus gnavus, like Akkermansia muciniphila is a mucin degrading specialist. HIGHER LEVELS: - Higher levels of Ruminococcus spp. were associated with non-alcoholic fatty liv
Learn moreMembers of Ruminococcus sensu produce acetate, but not butyrate. Ruminococcus gnavus, like Akkermanisia muciniphila is a mucin degrading specialist.
Learn moreSalmonella are facultative anaerobic bacteria in the family of Enterobacteriaceae. There are two species of Salmonella, Salmonella enterica and Salmonella bongori that include over 2,600 different serotypes. The majority of the pathogenic serotypes o
Learn moreFecal Secretory IgA is a marker of gut secretory immunity and barrier function. Immunoglobulin A (IgA) is an antibody playing a critical role in mucosal immunity and is produced in greater quantities than all other types of antibody combined. I
Learn moreE. coli are a diverse group of bacteria that normally live in the intestines of humans and animals. Although most strains of these bacteria are harmless, some produce toxins that can make you sick and cause diarrhea (loose stool/poop) such as Sh
Learn moreShigella spp. are non-sporulating bacteria that belong to the family Enterobacteriaceae. Shigella infections account for 5% to 20% of all diarrheal episodes throughout the world, and although these infections are commonly seen in children younger tha
Learn moreStreptococcus agalactiae, also known as Lancefield’s group B streptococcus (GBS), is a gram-positive facultative anaerobe. Found in around 30% of healthy adult gastrointestinal tracts and vaginas, it can cause severe infections. The bacterium i
Learn moreImbalanced bacteria are usually neither pathogenic nor beneficial to the host GI tract. Imbalances can occur when there are insufficient levels of beneficial bacteria and increased levels of commensal bacteria. Certain commensal bacteria are reported
Learn moreStreptococcus is a member of Gram-positive lactic acid-producing bacteria (LAB) that belonged to Firmicutes phylum. Many strains of Streptococcus are non-pathogenic and occur as commensal flora on the skin, the oral cavity, n
Learn moreHigher abundance of S. salivarius and S. thermophilus (Firmicutes phylum) have been associated with a moderate to severe disease course in newly diagnosed ulcerative colitis (UC) patients. These findings are in accordance with a study that showed
Learn moreHigher abundance of S. salivarius and S. thermophilus (Firmicutes phylum) have been associated with a moderate to severe disease course in newly diagnosed ulcerative colitis (UC) patients.
Learn moreHigher abundance of S. salivarius and S. thermophilus (Firmicutes phylum) have been associated with a moderate to severe disease course in newly diagnosed ulcerative colitis (UC) patients. These findings are in accordance with a study that showed tha
Learn moreHigher abundance of S. salivarius and S. thermophilus (Firmicutes phylum) have been associated with a moderate to severe disease course in newly diagnosed ulcerative colitis (UC) patients. These findings are in accordance with a study that showed tha
Learn moreHigher abundance of S. salivarius and S. thermophilus (Firmicutes phylum) have been associated with a moderate to severe disease course in newly diagnosed ulcerative colitis (UC) patients. These findings are in accordance with a study that showed tha
Learn moreStrongyloides infects the duodenum and jejunum, but its life cycle also includes migration through the lungs. Infection occurs when larvae penetrate the skin of humans or are passed via the fecal-oral route. Strongyloidiasis is endemic throughout th
Learn moreThese cestodes usually infect the intestinal tract, but Taenia solium may also invade the CNS. Transmission is by ingesting cysts in raw or undercooked meat. Taenia solium transmission may also occur via the fecal-oral route, which increases chance o
Learn moreT. trichiura is a nematode that infects the large intestine. Infection is spread via the fecal-oral route. The parasite is found principally in the tropics and subtropics. Mild asymptomatic infections are common in rural parts of the southeastern USA
Learn moreVegetable fibers in the stool may be indicative of inadequate chewing, or eating “on the run”.
Learn moreVeillonella are anaerobic, gram-negative cocci, part of the normal flora of the mouth, gastrointestinal tract, and vaginal tract.
Learn moreVibrio cholerae is one of the most common causes of diarrhea worldwide. While diarrhea associated with V. cholerae is predominately seen in the Indian subcontinent, South East Asia, Africa, and South America, sporadic cases of V. cholerae-induced dia
Learn moreWhite Blood Cells (WBC) and Mucus in the stool can occur with bacterial and parasitic infections, with mucosal irritation, and inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis. Elevated levels of WBCs in the stool ar
Learn moreYeast may normally be present in small quantities on the skin, in the mouth and intestine. While small quantities of yeast may be normal, yeast observed in higher quantities is considered abnormal.
Learn more