Creatinine (Urine) - DUTCH

Urine

Performed by: Precision Analytical (DUTCH)

- In this category of the DUTCH test you can see your Creatinine values of all four samples taken.

- Creatinine is measured to correct results for urine dilution.

- Creatinine values fluctuate with hydration levels.

What is creatinine correction, and does it produce valid results?

As a urine sample gets more diluted (=thinner/weaker), the concentration of the hormone decreases. The creatinine value decreases in parallel and corrects for hydration.

Because creatinine is excreted in a predictable way, this has been used by labs for many years with respect to many different urinary laboratory tests. The Dutch test is based on the assumption that a 24-hour collection is the gold standard for urine hormone testing. A 24-hour collection can be difficult to complete correctly as it is challenging for the patient. If a 24-hour collection is done correctly, DUTCH values compare favorably. This correlation data is critical in concluding that creatinine correction, as used in the DUTCH test, is effective for producing results reasonably equivalent to 24- hour urine values.

- If a patient has abnormal creatinine clearance, it could affect the results.

- 24-hour urine tests are dependent on people collecting their samples correctly and measuring the total volume accurately.

Additional note: Any urine test (DUTCH or 24-hour) should not be used for free cortisol assessment if the patient is known to have an abnormal glomerular filtration rate (cortisol may be artificially low in cases with low GFR).

Creatinine (Urine) - DUTCH

Performed by: Precision Analytical (DUTCH)

Biomarkers included in this panel:

Creatinine A (Waking)

Creatinine B (Morning)

Creatinine C (Afternoon)

Creatinine D (Night)

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