Phosphoethanolamine is an intermediate in the serine-to-choline sequence. It is both a precursor and byproduct of phospholipid biosynthesis and breakdown. As a precursor to the phospholipid phosphatidylethanolamine, phosphoethanolamine plays a key role in myelination. Elevated phosphoethanolamine reflects brain phospholipid turnover, an indicator of neural membrane synthesis and signal transduction. Research into neurologic conditions like Alzheimer’s disease and Huntington’s disease suggests that depletions of both phosphoethanolamine and ethanolamine accompany neuronal death. Phosphoethanolamine is also important in cartilage structure and function, especially in bone and teeth.
- Henneberry AL, McMaster CR. Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine. Biochem J. 1999;339 ( Pt 2)(Pt 2):291-298.
- Horibata Y, Hirabayashi Y. Identification and characterization of human ethanolaminephosphotransferase1. J Lipid Res. 2007;48(3):503-508.
- Kawamura N, Shinoda K, Sato H, et al. Plasma metabolome analysis of patients with major depressive disorder. Psych Clin Neurosci. 2018;72(5):349-361.
- Ellison DW, Beal MF, Martin JB. Phosphoethanolamine and ethanolamine are decreased in Alzheimer’s disease and Huntington’s disease. Brain Res. 1987;417(2):389-392.
- Roberts SJ, Stewart AJ, Sadler PJ, Farquharson C. Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities. Biochem J. 2004;382(Pt 1):59-65.
- Nowicki EM, O’Brien JP, Brodbelt JS, Trent MS. Extracellular zinc induces phosphoethanolamine addition to Pseudomonas aeruginosa lipid A via the ColRS twocomponent system. Molec Microbiol. 2015;97(1):166-178.
- Jo S-H, Park H-G, Song W-S, et al. Structural characterization of phosphoethanolamine-modified lipid A from probiotic Escherichia coli strain Nissle 1917. RSC Adv. 2019;9(34):19762-19771.
- Mornet E. Hypophosphatasia. Metab: Clin Exp. 2018;82:142- 155.
- Weismann K, Høyer H. Serum alkaline phosphatase and serum zinc levels in the diagnosis and exclusion of zinc deficiency in man. Am J Clin Nutr. 1985;41(6):1214-1219.
- Ray CS, Singh B, Jena I, Behera S, Ray S. Low alkaline phosphatase (ALP) in adult population an indicator of zinc (Zn) and magnesium (Mg) deficiency. Curr Res Nutr Food Sci J. 2017;5(3):347-352.
- Fukushima K, Kawai-Kowase K, Yonemoto Y, et al. Adult hypophosphatasia with compound heterozygous p.Phe327Leu missense and c.1559delT frameshift mutations in tissue-nonspecific alkaline phosphatase gene: a case report. J Med Case Rep. 2019;13(1):101.
Plasma phosphoethanolamine was higher in infants with spinal muscular atrophy and in patients with major depressive disorder (along with plasma beta-aminoisobutyric acid, cystathionine, and homocystine).
Elevated phosphoethanolamine reflects brain phospholipid turnover, an indicator of neural membrane synthesis and signal transduction. Research into neurologic conditions like Alzheimer’s disease and Huntington’s disease suggests that depletions of both phosphoethanolamine and ethanolamine accompany neuronal death. Phosphoethanolamine is also important in cartilage structure and function, especially in bone and teeth.
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