Albumin is not normally found in urine. Temporary dysfunction of the filtration barrier can occur under certain conditions, including fever, dehydration, a urinary tract infection (UTI), and after vigorous exercise, allowing small amounts of albumin through the barrier.
Recommendations for follow-up include three measurements one month apart. Although microalbuminuria does have relatively benign causes, its presence in urine should be further evaluated for serious and chronic conditions.
Many factors affect levels, including gender, race, blood pressure, time of day, exercise, dehydration, smoking, hypertension, diabetes, muscle mass, and amount of food, water, and salt intake, producing up to a 40% daily variation.
Endothelial dysfunction is likely to be involved in the initiation and development of microalbuminuria, initially reversible but becoming fixed with increasing vascular structural changes.
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