Collagen Catabolism: Collagen contains proline, hydroxyproline, and glycine.
→ Sarcopenia (low muscle mass) was associated with higher plasma proline.
→ Proline was significantly lower in esophageal cancer patients compared to the healthy controls.
→ Hydroxyproline and proline together constitute around 25% of residues and allow for stability and twisting of collagen.
→ Dietary intake increases levels of proline and hydroxyproline.
→ Proline and hydroxyproline both negatively correlated with a higher likelihood of anxiety, depression, and psychoses.
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