OMX Organic Metabolomics / Diagnostic Solutions

Isoleucine/allo-Isoleucine (Plasma)

Optimal Result: 35.5 - 112.4 nmol/ML.

Branched Chain Amino Acids (Isoleucine, Leucine, Valine) are the three branched chain amino acids (BCAAs). Branched chain amino acids (BCAA) are essential amino acids and must be obtained from the diet (mainly meat, grains, and dairy).

Branched-Chain Amino Acids (BCAAs) are required for protein synthesis and are metabolized outside hepatic tissues, unlike most other essential amino acids. They are converted to branched-chain keto acids which require B-complex vitamins. BCAAs have been associated with obesity, weight loss, insulin resistance, and nonalcoholic fatty liver disease (NAFLD). 

BCAA’s are nitrogen donors, facilitate glucose uptake by liver and skeletal muscle, and enhance glycogen synthesis.

- BMI was positively associated with urine 2-hydroxyisobutyrate, isoleucine, valine, tryptophan, and tyrosine.

- Elevated urine levels were associated with higher colorectal cancer.

What does it mean if your Isoleucine/allo-Isoleucine (Plasma) result is too low?

– Low BCAAs are an indication of chronic depletion from low protein intake, poor digestion, or increased utilization from chronic over-exercising.

– Studies have shown that low levels of isoleucine in plasma indicate an increased need for niacin. Chronic deficiency can cause hypoglycemia, loss of muscle mass, or inability to build muscle.

– Isoleucine and the other branched chain amino acids can be low as a result of zinc deficiency (zinc dependent intestinal peptidase), protein malnutrition or other gastrointestinal dysfunctions.

– A chronic deficiency of this AA can cause hypoglycemia and related problems and loss of muscle mass or inability to build muscle.

What does it mean if your Isoleucine/allo-Isoleucine (Plasma) result is too high?

- BMI was positively associated with urine 2-hydroxyisobutyrate, isoleucine, valine, tryptophan, and tyrosine.

- Elevated urine levels were associated with higher colorectal cancer.

- High fasting levels may be caused by a deficiency of vitamin B6, elevated insulin levels, or excessive BCAA intake.

- Studies found that plasma BCAA levels can be associated with animal protein consumption. Dairy products and red meat contain the greatest amounts of BCAAs, although they are present in all protein-containing foods. Whey protein and egg protein supplements are other sources of BCAAs. Lowering the intake of these foods can lower the isoleucine plasma levels.

Possible treatment:

Lower your BCAA intake by focusing on a whole foods plant-based diet. Check also for sufficient vitamin B6 intake to aid metabolism.

10 000+ happy clients
100% satisfaction
★ ★ ★ ★ ★ customer support

Understand blood, stool, and urine medical results from all your laboratories.

Get Started With Our Personal Plan

Advanced Plan

  • ✓ Yearly subscription
  • ✓ Five free uploads
  • ✓ Cancel anytime
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support
  • ✓ Yearly subscription
  • ✓ Five free uploads
  • ✓ Cancel anytime
$79 per year
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support

Unlimited Plan

  • ✓ No subscription
  • ✓ Ten free uploads
  • ✓ Unlimited access
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support
  • ✓ No subscription
  • ✓ Ten free uploads
  • ✓ Unlimited access
$250 full version

Are You a Health Professional?

Get started with our professional plan

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more

Pro Plan

for health professionals

  • ✓ Track multiple clients results
  • ✓ No setup fees
  • ✓ No hidden costs
  • ✓ Cancel anytime
  • ✓ Instant interpretations
  • ✓ Use the free template forms
  • ✓ 3000+ biomarkers explained
  • ✓ Additional team member $25
  • ✓ Personal training and support

$45 per month

Use promo code to save 10% off any plan.


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

×

Understand Your Lab Result Now

  • Instant interpretation
  • 3000+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode: