Arginine
Optimal Result:
0 - 26.4 nmol/mg Creatinine.
→ Arginine is a precursor of urea, nitric oxide, polyamines (putrescine, spermidine, spermine and agmatine), proline, glutamate, and creatine.
→ Levels may drop with increased need, or in renal or small intestine dysfunction.
→ Synthesis of arginine depends on citrulline levels and is less regulated by dietary arginine. Supplementation with citrulline increases plasma arginine and the production of nitric oxide (NO).
→ Arginine supplementation may lower blood pressure.
→ Metabolism of elevated arginine levels is dependent on glycine availability.
→ Plasma arginine and ornithine increased, while citrulline remained stable, following watermelon juice intake, a rich source of citrulline.
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Arginine, a significant marker on the OMX Organix Metabolomics Panel, holds a pivotal role in the realm of metabolic health and biochemical analysis. This essential amino acid, often spotlighted in nutritional and medical discussions, serves as a critical building block for proteins, thereby playing a vital part in various bodily functions. In the context of the OMX Organix Metabolomics Panel, arginine's presence and levels provide invaluable insights into an individual's metabolic state, particularly in areas concerning protein synthesis, ammonia detoxification, and the production of nitric oxide - a key molecule in cardiovascular health.
Elevated or reduced levels of arginine can be indicative of several health conditions, ranging from metabolic disorders to issues in amino acid metabolism, making it a vital parameter in comprehensive health assessments.
Lab Results Explained and Tracked
What does it mean if your Arginine result is too high?
High levels of Arginine on an OMX test panel by Diagnostic Solutions Laboratory may indicate an imbalance in amino acid metabolism, often related to impaired utilization of arginine in the urea cycle or dysfunction in nitric oxide synthesis. Elevated arginine can occur when the liver’s urea cycle enzymes (such as arginase) are underactive, leading to reduced conversion of arginine to ornithine and urea. It may also reflect supplement overuse, kidney dysfunction, or increased protein breakdown. Since arginine is a precursor for nitric oxide, elevated levels can affect vascular tone, immune function, and ammonia detoxification. Persistently high arginine should be interpreted in context with other urea cycle intermediates (like ornithine and citrulline) and overall amino acid balance.
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