- Synthesized in muscle myofibrillar proteins; urine marker associated with skeletal muscle.
- 3-methylhistidine is best measured in a diet maintaining a constant meat intake. Evaluate amino acid status and levels of activity.
3-Methylhistidine is an amino acid which is excreted in human urine.
The measurement of 3-methylhistidine provides an index of the rate of muscle protein breakdown. 3-Methylhistidine is a biomarker for meat consumption, especially chicken. It is also a biomarker for the consumption of soy products.
- Urinary 1-Methylhistidine Is a Marker of Meat Consumption in Black and in White California Seventh-day Adventists [L]
- Urinary Biomarkers of Meat Consumption [L]
This methylated form of histidine comes from muscle tissue, both dietary and endogenous, where it is part of the muscle proteins actin and myosin. A moderate level of urine 3-methylhistidine is normal.
3-Methylhistidine is a biomarker for meat consumption, especially chicken. It is also a biomarker for the consumption of soy products.
Elevated levels suggest either an inordinately high intake of dietary actin/myosin or accelerated catabolism of muscle tissue. 3-Methylhistidine excretion is increased after strenuous physical exercise and also occurs in muscle wasting conditions - dystrophies, lack of exercise, extended bed rest, terminal stages of severe illness. Convulsions and seizures also feature increased urinary 3-methylhistidine. There is some correlation between elevated 3-methylhistidine and increased need for vitamin B12, folic acid, methionine and perhaps histidine if it is marginal or low.
If these deficiencies show up elsewhere on this test, then even though protein is burning at a rate, the Krebs cycle is operating at a lower rate than normal. This is consistent with fatigue and low body temperature.
If Histidine is also high:
May indicate excessive protein intake. Muscle protein breakdown is indicated.
If Beta-Alanine is also high:
Possible cause for food sensitivity reactions when combined with low taurine and high Beta-Alanine due to impaired renal tubular resorption.
Our specialized data entry service is designed to seamlessly integrate your laboratory results into your private dashboard. Just send in your lab test results—whether it's an image or a file—and our skilled data entry team will handle the rest. We accommodate various file formats like PDFs, JPGs, and Excel.
The first report is complimentary. After that, the data entry service is priced at $15 per report, unless it's part of your subscribed plan. It's an ideal solution whether you have numerous reports to upload or if your schedule doesn't permit self-data entry.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
track personal results
track multiple client's results
own it for life
for health professionals
for personal lab results
own it for life
Level up your lab report analysis with our Pro plan, built for health practitioners like you.
Health Business Account
Unlock additional Pro plans when you sign up.