→ Mandelic acid and benzoylformate are major metabolites of styrene and ethylbenzene exposure.
→ Styrene is a key component in consumer products. Occupational exposure has been associated with increased rates of pulmonary, neurological, genetic, ocular, and reproductive complications, plus leukemia.
→ Styrene can be found in polystyrene packaging and can migrate into packaged food.
→ Benzoylformate has been associated with metabolism of adrenaline and noradrenaline, and phenylketonuria.
→ In a review of 2005–2006 and 2011–2012 NHANES data (N=4690), smokers had 2-fold and 1.6-fold higher levels of both markers.
→ Eating more vegetables and fruit was associated with decreased levels.
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